Ebook: Ribosomes
Author: Alexander S. Spirin (auth.)
- Tags: Biochemistry general
- Series: Cellular Organelles
- Year: 1999
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
This book is based on an advanced course of lectures on ribosome structure and protein biosynthesis that I offer at the Moscow State University. These lectures have been part of a general course on molecular biology for almost three decades, and they have undergone considerable evolution as knowledge has been pro gressing in this field. The progress continues, and readers should be prepared that some facts, statements, and ideas included in the book may be incomplete or out of-date. In any case, this is primarily a textbook, but not a comprehensive review. It provides a background of knowledge and current ideas in the field and gives ex amples of observations and their interpretations. I understand that some interpre tations and generalizations may be tentative or disputable, but I hope that this will stimulate thinking and discussing better than if I left white spots. The book has a prototype: it is my monograph "Ribosome Structure and Pro tein Biosynthesis" published by the Benjamin/Cummings Publishing Company, Menlo Park, California, in 1986. Here I have basically kept the former order of pre sentation ofthe topics and the subdivision into chapters. The contents ofthe chap ters, however, have been significantly revised and supplemented. The newly writ ten chapters on translational control in prokaryotes (Chapter 16) and eukaryotes (Chapter 17) are added.
Content:
Front Matter....Pages i-xv
Front Matter....Pages 1-1
Protein Biosynthesis....Pages 3-5
Messenger RNA and the Genetic Code....Pages 7-22
Transfer RNA and Aminoacyl-tRNA Synthetases....Pages 23-45
Ribosomes and Translation....Pages 47-60
Front Matter....Pages 61-61
Morphology of the Ribosome....Pages 63-73
Ribosomal RNA....Pages 75-95
Ribosomal Proteins....Pages 97-116
Mutual Arrangement of Ribosomal RNA and Proteins (Quaternary Structure)....Pages 117-129
Front Matter....Pages 131-131
Functional Activities and Functional Sites of the Ribosome....Pages 133-161
Elongation Cycle, Step I: Aminoacyl-tRNA Binding....Pages 163-193
Elongation Cycle, Step II: Transpeptidation (Peptide Bond Formation)....Pages 195-211
Elongation Cycle, Step III: Translocation....Pages 213-239
Elongation Rate and its Modulation....Pages 241-259
Termination of Translation....Pages 261-270
Initiation of Translation....Pages 271-308
Translational Control in Prokaryotes....Pages 309-338
Translational Control in Eukaryotes....Pages 339-369
Cotranslational Folding and Transmembrane Transport of Proteins....Pages 371-396
Conclusion: General Principles of Ribosome Structure and Function....Pages 397-405
Back Matter....Pages 407-416
Content:
Front Matter....Pages i-xv
Front Matter....Pages 1-1
Protein Biosynthesis....Pages 3-5
Messenger RNA and the Genetic Code....Pages 7-22
Transfer RNA and Aminoacyl-tRNA Synthetases....Pages 23-45
Ribosomes and Translation....Pages 47-60
Front Matter....Pages 61-61
Morphology of the Ribosome....Pages 63-73
Ribosomal RNA....Pages 75-95
Ribosomal Proteins....Pages 97-116
Mutual Arrangement of Ribosomal RNA and Proteins (Quaternary Structure)....Pages 117-129
Front Matter....Pages 131-131
Functional Activities and Functional Sites of the Ribosome....Pages 133-161
Elongation Cycle, Step I: Aminoacyl-tRNA Binding....Pages 163-193
Elongation Cycle, Step II: Transpeptidation (Peptide Bond Formation)....Pages 195-211
Elongation Cycle, Step III: Translocation....Pages 213-239
Elongation Rate and its Modulation....Pages 241-259
Termination of Translation....Pages 261-270
Initiation of Translation....Pages 271-308
Translational Control in Prokaryotes....Pages 309-338
Translational Control in Eukaryotes....Pages 339-369
Cotranslational Folding and Transmembrane Transport of Proteins....Pages 371-396
Conclusion: General Principles of Ribosome Structure and Function....Pages 397-405
Back Matter....Pages 407-416
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