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It is remarkable how much we take for granted the tremendous energy and vitality that the sun provides earth's inhabitants. As we enter the new millennium, it is worthwhile to review how our ancestors perceived the biologic effects of sunlight, and how science and medicine have advanced our knowledge about the biologic effects of light.
At the turn of the century, a multitude of investigators explored the use of sunlight and artificial radiation for treating a multitude of diseases. These explorations gave rise to photodynamic therapy, phototherapy, and chemophototherapy. However, enthusiasm for using sunlight and artificial radiation to treat disease was dampened with the birth of pharmacology.
It was the goal of the Fifth International Arnold Rikli Symposium on the Biologic Effects of Light, held in Basel, Switzerland, on November 1-3, 1998, to review the history of phototherapy and have some of the world's leading experts on the biologic effects of light provide new perspectives on the positive and negative effects of light. The general topics included a broad range of biologic effects of sunlight, artificial ultraviolet radiation and electromagnetic radiation. Special sessions on radiation and vitamin D and bone health, photoimmunology, biopositive effects of UV radiation, effects of electromagnetic currents and fields, and ocular and non-ocular regulation of circadian rhythms and melatonin, should be of particular interest to readers of Biologic Effects of Light.




It is remarkable how much we take for granted the tremendous energy and vitality that the sun provides earth's inhabitants. As we enter the new millennium, it is worthwhile to review how our ancestors perceived the biologic effects of sunlight, and how science and medicine have advanced our knowledge about the biologic effects of light.
At the turn of the century, a multitude of investigators explored the use of sunlight and artificial radiation for treating a multitude of diseases. These explorations gave rise to photodynamic therapy, phototherapy, and chemophototherapy. However, enthusiasm for using sunlight and artificial radiation to treat disease was dampened with the birth of pharmacology.
It was the goal of the Fifth International Arnold Rikli Symposium on the Biologic Effects of Light, held in Basel, Switzerland, on November 1-3, 1998, to review the history of phototherapy and have some of the world's leading experts on the biologic effects of light provide new perspectives on the positive and negative effects of light. The general topics included a broad range of biologic effects of sunlight, artificial ultraviolet radiation and electromagnetic radiation. Special sessions on radiation and vitamin D and bone health, photoimmunology, biopositive effects of UV radiation, effects of electromagnetic currents and fields, and ocular and non-ocular regulation of circadian rhythms and melatonin, should be of particular interest to readers of Biologic Effects of Light.


It is remarkable how much we take for granted the tremendous energy and vitality that the sun provides earth's inhabitants. As we enter the new millennium, it is worthwhile to review how our ancestors perceived the biologic effects of sunlight, and how science and medicine have advanced our knowledge about the biologic effects of light.
At the turn of the century, a multitude of investigators explored the use of sunlight and artificial radiation for treating a multitude of diseases. These explorations gave rise to photodynamic therapy, phototherapy, and chemophototherapy. However, enthusiasm for using sunlight and artificial radiation to treat disease was dampened with the birth of pharmacology.
It was the goal of the Fifth International Arnold Rikli Symposium on the Biologic Effects of Light, held in Basel, Switzerland, on November 1-3, 1998, to review the history of phototherapy and have some of the world's leading experts on the biologic effects of light provide new perspectives on the positive and negative effects of light. The general topics included a broad range of biologic effects of sunlight, artificial ultraviolet radiation and electromagnetic radiation. Special sessions on radiation and vitamin D and bone health, photoimmunology, biopositive effects of UV radiation, effects of electromagnetic currents and fields, and ocular and non-ocular regulation of circadian rhythms and melatonin, should be of particular interest to readers of Biologic Effects of Light.
Content:
Front Matter....Pages i-xv
Front Matter....Pages 1-1
Rhythmic Transcription: The Molecular Basis of Circadian Melatonin Synthesis....Pages 3-10
Biologic Effects of Light: Historical and New Perspectives....Pages 11-32
Phototherapy Today....Pages 33-36
Relationships Among Illumination, Activity, and Sleep Patterns....Pages 37-39
Comet Assay to Study UV-Induced DNA Damage....Pages 41-43
Are UV-Irradiation Effects Similar to Erythropoietin? Case Study in Hemodialysis patients during serial UVB-irradiation....Pages 45-48
Suberythemal UV-Irradiation Increases Immunological Capacity in Children With Frequent Cold....Pages 49-51
UV-Irradiation Affects Antioxidants in the Intravascular Compartment....Pages 53-55
Action Sites of UV-B Radiation in the Nitrate Assimilation Pathway of Crop Plants....Pages 57-59
Decreased Serum Concentration of Osteocalcin After Sunshine Exposure....Pages 61-65
Methodology for an Epidemiological Study of Individually Received Biological-Effective Solar UV-exposure in the Course of the Year....Pages 67-70
Stimulation of 25(OH)D3-Serum Level by Minimized UV-Exposures of Different Sunbed Lamps in Winter Time....Pages 71-73
Moon-and nightlight Stimulate germination of sensitized lettuce....Pages 75-77
Front Matter....Pages 79-82
New Aspects on the Photobiology of Vitamin D....Pages 83-83
Seasonal Bone Loss in Elderly Women: Pathogenesis and Potential Implications....Pages 85-91
Evaluation of Vitamin D Status in the Green Iguana (Iguana iguana): Oral Administration vs UVB Exposure....Pages 93-98
Photobiosynthesis in Lizards: Opportunity, Ability and Behavioral Regulation....Pages 99-101
The Role of Sunlight, Artificial UV Radiation and Diet on Bone Health in Zoo Animals....Pages 103-109
Serial UVB Irradiation Can Influence Secondary Hyperparathyroidism in Vitamin D Deficiency....Pages 111-119
Front Matter....Pages 121-123
Evaluation of the Artificial UV-Sources on Vitamin D3 Synthesis in Humans....Pages 83-83
Exposure to a Suberythemal Dose of Ultraviolet Irradiation Prevents Bone Loss in Hemodialysis Patients....Pages 125-127
Dose-Response Relationship of Vitamin D3 Synthesis During Serial UV-Irradiation in Dialysis Patients....Pages 129-131
Ultraviolet Light Requirements of Panther Chameleons in Captivity....Pages 133-135
Parameters of Bone Metabolism -in Particular Vitamin D3 Level-in Serum of Patients with Osteoporosis after Treatment with Natural Sunlight (in Highlands, High Mountain Area and on the Sea) after Artificial UVB Radiation....Pages 137-140
An Evaluation of the Biologic Activity and Vitamin D Receptor Binding Affinity of the Photoisomers of Vitamin D3, Previtamin D3 and Their Hydroxylated Derivatives....Pages 141-143
Vitamin D -vs- Erythema: Effects of Solar Angle & Artificial Sources....Pages 145-148
Combined Study of Antirachitic Solar UVB Radiation by Spectroradiometer and “Vitamin D” Biodosimeter....Pages 149-152
UVB-Induced Conversion of 7-Dehydrocholesterol to l?,25-DI Hydroxyvitamin D3 (Calcitriol) in Cultured Keratinocytes....Pages 153-155
Markers of Vitamin D Intake and Risk of Breast Cancer in a California Population....Pages 157-159
Meta-analysis of Vitamin D and Colon Cancer....Pages 161-164
“Vitamin D” Biodosimeter: A New Tool for Measuring the Beneficial Effects of UVB Radiation....Pages 165-168
Front Matter....Pages 169-172
Molecular Pathophysiology of Photoaging in Human Skin and the Effect of All-Trans Retinoic Acid....Pages 173-173
Impact of UVB Radiation on Langerhans Cells: In Vitro Studies Using XS52 Cell Line....Pages 175-180
Molecular Basis of Photoimmunologic Effects....Pages 181-190
High-Dose UVA1 Therapy of Atopic Dermatitis and Scleroderma....Pages 191-196
Ultraviolet Radiation and HIV Infection: What Do We Know and Should Know?....Pages 197-203
Immunosuppression Induced by the Photooxidation Products of Furucoumarins (Psoralens)....Pages 205-211
Front Matter....Pages 213-216
Expression of hMSH-2 Mismatch-Repair Gene in Epithelial and Melanocytic Skin Tumors: Regulation by P53 Protein and UV-B Irradiation....Pages 217-217
Commercial Tanning Bed Treatment is an Effective Psoriasis Treatment: Results from an Uncontrolled Trial....Pages 219-226
Front Matter....Pages 227-235
Epidemiology and the Role of Sunlight....Pages 217-217
UV Irradiation and Blood Pressure — the Role of Vitamin D in Essential Hypertension....Pages 237-248
Betacarotene for the Prevention of Ultraviolet-Induced Skin Damage....Pages 249-255
UV-Exposure of Mountain Guides and Ski Instructors- Personal Uv-Dosimetry by Bacillus Subtilis- Pore Films....Pages 257-262
Solar UVR Exposure of Infants and Small Children in Townsville, Australia....Pages 263-265
Efficacy of Sunscreens in Relation to the Horny Layer....Pages 267-273
Front Matter....Pages 275-278
Electromagnetic Fields (EMF):Mode of Action....Pages 279-279
Effects of ULF Fields on Extra-and Intracranial Arterial and Venous Circulation....Pages 281-286
Do Ultra-Low Frequency ULF) Magnetic Fields Affect the Blood-Brain Barrier?....Pages 287-295
Effects of Interferential Current in Cellular Systems....Pages 297-301
Effects of Interferential Current on UV-Induced DNA-Damage....Pages 303-311
The Effect of Electromagnetic Field Exposure on the formation of DNA Single Strand Breaks....Pages 313-317
Front Matter....Pages 319-322
Interferential Current in the Treatment of Palmar Psoriasis....Pages 323-323
Low Frequency Magnetic Fields Influence Brain Activity and Blood Flow of Man....Pages 325-330
Pulsing Magnetic Field Effects on Brain Electrical Activity in Multiple Sclerosis....Pages 331-336
Magnetic Fields and Malaria....Pages 337-342
Role of Light in Breast Cancer....Pages 343-349
Low Frequency Magnetic Fields Influence Cerebral Blood Flow and Brain Activity....Pages 351-357
Front Matter....Pages 359-363
Ocular Regulation of the Human Pineal Gland: the Significance of Total Retinal Exposure for Melatonin Suppression....Pages 365-365
Light Perception and Melatonin Rhythms in the Blind....Pages 367-374
Front Matter....Pages 375-381
Melatonin and Phase Shifting....Pages 365-365
Circadian Clock Resetting in Humans by Extraocular Light Exposure....Pages 383-388
Humoral Phototransduction:Theory, Fact, or Fiction?....Pages 389-395
Extraocular Light Exposure Does Not Suppress Plasma Melatonin in Humans....Pages 397-402
Front Matter....Pages 403-406
Light Treatment in Depression(SAD, s-SAD & non-SAD)....Pages 407-407
Light Treatment for Sleep-Wake Disorders in Elderly Patients with Dementia....Pages 409-416
Light Exposure, Sleep Quality, and Depression in Older Adults....Pages 417-426
Light Exposure and Melatonin Secretion in Shiftworkers....Pages 427-435
Jet Lag at the Olympics: 24-Hour Blood Pressure Profile and Time Zone Transition....Pages 437-446
The Sympatho-Adrenal and Energy-Regulating Systems in Winter Depression....Pages 447-454
Front Matter....Pages 455-458
The Results Of In Vivo 5-Aminolevulinic Acid Photodynamic Therapy Of Transplantable C51 Colon Adenocarcinoma....Pages 459-459
Lack of Dose-Response Effect Of Nocturnal Light on Menstrual Cycle Length....Pages 461-466
Light Exposure and Quality of Life in Older Schizophrenia and Schizoaffective Disorder Patients....Pages 467-469
Quantum Yield of Flavins in a Monomer Fluorescent Dimer System....Pages 471-473
Back Matter....Pages 475-478
....Pages 479-491
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