Ebook: Relaxin and the Fine Structure of Proteins

Relaxin, perhaps more than any other hormone, has a varied history of eliciting enthusiasm, rejection, skepticism, and long lapses of neglect. Long after its discovery, it was a hormone in search of a physiological role in humans. Today, relaxin is implicated in mammary growth, development and function, ionotropic and chronotropic action on the heart, and angiogenic activity in both the peripheral tissues and the endometrium. It is best known for its effect on the uterus and the symphysis pubis in preparation for parturition. However, the literature suggests that not all functions occur in one species. This book describes how to obtain the necessary molecules or derivatives for research, reaching right into the design of new molecules for specific applications.

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Relaxin, perhaps more than any other hormone, has a varied history of eliciting enthusiasm, rejection, skepticism, and long lapses of neglect. Long after its discovery, it was a hormone in search of a physiological role in humans. Today, relaxin is implicated in mammary growth, development and function, ionotropic and chronotropic action on the heart, and angiogenic activity in both the peripheral tissues and the endometrium. It is best known for its effect on the uterus and the symphysis pubis in preparation for parturition. However, the literature suggests that not all functions occur in one species. This book describes how to obtain the necessary molecules or derivatives for research, reaching right into the design of new molecules for specific applications.

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Relaxin, perhaps more than any other hormone, has a varied history of eliciting enthusiasm, rejection, skepticism, and long lapses of neglect. Long after its discovery, it was a hormone in search of a physiological role in humans. Today, relaxin is implicated in mammary growth, development and function, ionotropic and chronotropic action on the heart, and angiogenic activity in both the peripheral tissues and the endometrium. It is best known for its effect on the uterus and the symphysis pubis in preparation for parturition. However, the literature suggests that not all functions occur in one species. This book describes how to obtain the necessary molecules or derivatives for research, reaching right into the design of new molecules for specific applications.
Content:
Front Matter....Pages iii-ix
Introduction....Pages 1-4
A Very Brief History....Pages 5-8
The Relaxin Insulin-Like Motif in Protein Structures....Pages 9-11
Other Mammalian and Chondrichtian Relaxins....Pages 13-23
Isolation and Sequence Analysis of Porcine Relaxin....Pages 25-37
The Initial Approach to Receptor-Binding Site Studies....Pages 39-47
The N-Terminal Region of the Relaxin A Chain....Pages 49-57
The Total Synthesis of Human Relaxin....Pages 59-79
Analytic of the Prototype....Pages 81-89
The Receptor-Binding Site of Relaxin....Pages 91-99
Merely a G (Glycine)....Pages 101-110
The Development of Insulaxin, The First True “Zwitterhormon”....Pages 111-117
A Surprising Message from Murines....Pages 119-124
The Mouse, a Very Small Rat, a Very Big Mistake....Pages 125-128
Retro-D-Relaxin....Pages 129-132
The Relaxin-Like Factor....Pages 133-144
The Relaxin Receptor....Pages 145-160
Relaxin as a Drug....Pages 161-174
Relaxin and Genealogy....Pages 175-190
Back Matter....Pages 191-200

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Relaxin, perhaps more than any other hormone, has a varied history of eliciting enthusiasm, rejection, skepticism, and long lapses of neglect. Long after its discovery, it was a hormone in search of a physiological role in humans. Today, relaxin is implicated in mammary growth, development and function, ionotropic and chronotropic action on the heart, and angiogenic activity in both the peripheral tissues and the endometrium. It is best known for its effect on the uterus and the symphysis pubis in preparation for parturition. However, the literature suggests that not all functions occur in one species. This book describes how to obtain the necessary molecules or derivatives for research, reaching right into the design of new molecules for specific applications.
Content:
Front Matter....Pages iii-ix
Introduction....Pages 1-4
A Very Brief History....Pages 5-8
The Relaxin Insulin-Like Motif in Protein Structures....Pages 9-11
Other Mammalian and Chondrichtian Relaxins....Pages 13-23
Isolation and Sequence Analysis of Porcine Relaxin....Pages 25-37
The Initial Approach to Receptor-Binding Site Studies....Pages 39-47
The N-Terminal Region of the Relaxin A Chain....Pages 49-57
The Total Synthesis of Human Relaxin....Pages 59-79
Analytic of the Prototype....Pages 81-89
The Receptor-Binding Site of Relaxin....Pages 91-99
Merely a G (Glycine)....Pages 101-110
The Development of Insulaxin, The First True “Zwitterhormon”....Pages 111-117
A Surprising Message from Murines....Pages 119-124
The Mouse, a Very Small Rat, a Very Big Mistake....Pages 125-128
Retro-D-Relaxin....Pages 129-132
The Relaxin-Like Factor....Pages 133-144
The Relaxin Receptor....Pages 145-160
Relaxin as a Drug....Pages 161-174
Relaxin and Genealogy....Pages 175-190
Back Matter....Pages 191-200
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