Ebook: Ubiquitin and the Biology of the Cell
- Tags: Biochemistry general, Animal Anatomy / Morphology / Histology
- Year: 1998
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
The last several years have been a landmark period in the ubiquitin field. The breadth of ubiquitin's roles in cell biology was first sketched, and the importance of ubiquitin-dependent proteolysis as a regulatory mechanism gained general acceptance. The many strands of work that led to this new perception are re counted in this book. A consequence of this progress is that the field has grown dramatically since the first book on ubiquitin was published almost a decade ago [M. Rechsteiner (ed. ), Ubiquitin, Plenum Press, 1988]. In this span, students of the cell cycle, transcription, signal transduction, protein sorting, neuropathology, cancer, virology, and immunology have attempted to chart the role of ubi quit in in their particular experimental systems, and this integration of the field into cell biology as a whole continues at a remarkable pace. We hope that for active researchers in the field as well as for newcomers and those on the fence, this book will prove helpful for its breadth, historical perspective, and practical tips. Structural data are now available on many of the components of the ubiquitin pathway. The structures have provided basic insights into the unusual biochemical mechanisms of ubiquitination and proteasome-mediated proteolysis. Because high-speed computer graphics can convey structures more effectively than print media, we have supplemented the figures of the book with a Worldwide Web site that can display the structures in a flexible, viewer-controlled format.
Content:
Front Matter....Pages i-xxi
The Ubiquitin System....Pages 1-17
Polyubiquitin Chains....Pages 19-63
The Ubiquitin-Conjugation System....Pages 65-98
The Deubiquitinating Enzymes....Pages 99-125
The 20 S Proteasome....Pages 127-146
The 26 S Proteasome....Pages 147-189
Function of the Proteasome in Antigen Presentation....Pages 191-222
The N-End Rule Pathway....Pages 223-278
Ubiquitin-Dependent Degradation of Transcription Regulators....Pages 279-302
Role of the Ubiquitin—Proteasome Pathway in NF-?B Activation....Pages 303-322
Ubiquitination of the p53 Tumor Suppressor....Pages 323-343
Cell Cycle Control by Ubiquitin-Dependent Proteolysis....Pages 345-387
Ubiquitination of Integral Membrane Proteins and Proteins in the Secretory Pathway....Pages 389-409
Degradation of Ornithine Decarboxylase....Pages 411-428
Ubiquitin and the Molecular Pathology of Human Disease....Pages 429-462
Back Matter....Pages 463-472
Content:
Front Matter....Pages i-xxi
The Ubiquitin System....Pages 1-17
Polyubiquitin Chains....Pages 19-63
The Ubiquitin-Conjugation System....Pages 65-98
The Deubiquitinating Enzymes....Pages 99-125
The 20 S Proteasome....Pages 127-146
The 26 S Proteasome....Pages 147-189
Function of the Proteasome in Antigen Presentation....Pages 191-222
The N-End Rule Pathway....Pages 223-278
Ubiquitin-Dependent Degradation of Transcription Regulators....Pages 279-302
Role of the Ubiquitin—Proteasome Pathway in NF-?B Activation....Pages 303-322
Ubiquitination of the p53 Tumor Suppressor....Pages 323-343
Cell Cycle Control by Ubiquitin-Dependent Proteolysis....Pages 345-387
Ubiquitination of Integral Membrane Proteins and Proteins in the Secretory Pathway....Pages 389-409
Degradation of Ornithine Decarboxylase....Pages 411-428
Ubiquitin and the Molecular Pathology of Human Disease....Pages 429-462
Back Matter....Pages 463-472
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