Ebook: Apoptosis Genes

Apoptosis, or programmed cell death, is a natural process by which damaged or unwanted cells are dismantled in an orderly and atraumatic fashion. It is of critical importance in development, homeostasis, and cell population control. Research over the last decade is now enabling scientists to comprehend how genes and the protein products interact to control apoptosis. This has led to the current position where researchers may be able to directly modify the action of key proteins through gene therapy and antisense oligonucleotides.
Apoptosis Genes presents a current overview of key genes involved in the control of apoptosis research together with thoughts on future prospects and clinical applications. While there are several books written on apoptosis, Apoptosis Genes deals specifically with the regulation of apoptosis. Given the increased interest in the role of apoptosis genes in disease processes, this work will be useful to researchers investigating cancer, autoimmune disease, viral infection, cardiovascular disease, neurodegenerative disorders, AIDS, osteoporosis, and aging.

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Apoptosis, or programmed cell death, is a natural process by which damaged or unwanted cells are dismantled in an orderly and atraumatic fashion. It is of critical importance in development, homeostasis, and cell population control. Research over the last decade is now enabling scientists to comprehend how genes and the protein products interact to control apoptosis. This has led to the current position where researchers may be able to directly modify the action of key proteins through gene therapy and antisense oligonucleotides.
Apoptosis Genes presents a current overview of key genes involved in the control of apoptosis research together with thoughts on future prospects and clinical applications. While there are several books written on apoptosis, Apoptosis Genes deals specifically with the regulation of apoptosis. Given the increased interest in the role of apoptosis genes in disease processes, this work will be useful to researchers investigating cancer, autoimmune disease, viral infection, cardiovascular disease, neurodegenerative disorders, AIDS, osteoporosis, and aging.

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Apoptosis, or programmed cell death, is a natural process by which damaged or unwanted cells are dismantled in an orderly and atraumatic fashion. It is of critical importance in development, homeostasis, and cell population control. Research over the last decade is now enabling scientists to comprehend how genes and the protein products interact to control apoptosis. This has led to the current position where researchers may be able to directly modify the action of key proteins through gene therapy and antisense oligonucleotides.
Apoptosis Genes presents a current overview of key genes involved in the control of apoptosis research together with thoughts on future prospects and clinical applications. While there are several books written on apoptosis, Apoptosis Genes deals specifically with the regulation of apoptosis. Given the increased interest in the role of apoptosis genes in disease processes, this work will be useful to researchers investigating cancer, autoimmune disease, viral infection, cardiovascular disease, neurodegenerative disorders, AIDS, osteoporosis, and aging.
Content:
Front Matter....Pages i-ix
Introduction....Pages 1-4
The role of p53 in apoptosis....Pages 5-35
Mammalian bcl-2 family genes....Pages 37-84
Stress-responsive signal transduction: emerging concepts and biological significance....Pages 85-117
Control of Apoptosis Through Gene Regulation....Pages 119-142
Adhesion and Apoptosis....Pages 143-165
Death signalling in C. elegans and activation mechanisms of caspases....Pages 167-203
Apoptosis in Drosophila ....Pages 205-241
Viral genes that modulate apoptosis....Pages 243-279
Therapeutic manipulation of apoptosis in cancer and neurological disease....Pages 281-303
Back Matter....Pages 305-310

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Apoptosis, or programmed cell death, is a natural process by which damaged or unwanted cells are dismantled in an orderly and atraumatic fashion. It is of critical importance in development, homeostasis, and cell population control. Research over the last decade is now enabling scientists to comprehend how genes and the protein products interact to control apoptosis. This has led to the current position where researchers may be able to directly modify the action of key proteins through gene therapy and antisense oligonucleotides.
Apoptosis Genes presents a current overview of key genes involved in the control of apoptosis research together with thoughts on future prospects and clinical applications. While there are several books written on apoptosis, Apoptosis Genes deals specifically with the regulation of apoptosis. Given the increased interest in the role of apoptosis genes in disease processes, this work will be useful to researchers investigating cancer, autoimmune disease, viral infection, cardiovascular disease, neurodegenerative disorders, AIDS, osteoporosis, and aging.
Content:
Front Matter....Pages i-ix
Introduction....Pages 1-4
The role of p53 in apoptosis....Pages 5-35
Mammalian bcl-2 family genes....Pages 37-84
Stress-responsive signal transduction: emerging concepts and biological significance....Pages 85-117
Control of Apoptosis Through Gene Regulation....Pages 119-142
Adhesion and Apoptosis....Pages 143-165
Death signalling in C. elegans and activation mechanisms of caspases....Pages 167-203
Apoptosis in Drosophila ....Pages 205-241
Viral genes that modulate apoptosis....Pages 243-279
Therapeutic manipulation of apoptosis in cancer and neurological disease....Pages 281-303
Back Matter....Pages 305-310
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