Ebook: Multiple Drug Resistance in Cancer 2: Molecular, Cellular and Clinical Aspects

Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.

---

Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.

---

Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.
Content:
Front Matter....Pages i-xi
P-glycoprotein structure and evolutionary homologies....Pages 1-30
Molecular analysis of the multidrug transporter, P-glycoprotein....Pages 31-60
Mutagenesis of the putative nucleotide-binding domains of the multidrug resistance associated protein (MRP). Analysis of the effect of these mutations on MRP mediated drug resistance and transport....Pages 61-69
Membrane topology of the human multidrug resistance-associated protein (MRP) and its homologs....Pages 71-79
A new aspect on glutathione-associated biological function of MRP/GS-X pump and its gene expression....Pages 81-93
Intracellular distribution of anthracyclines in drug resistant cells....Pages 95-111
Use of ribozymes and antisense oligodeoxynucleotides to investigate mechanisms of drug resistance....Pages 113-136
Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP....Pages 137-148
Topoisomerase I inhibitors and drug resistance....Pages 149-164
Mechanisms of resistance to alkylating agents....Pages 165-173
Drug resistance and DNA repair in leukaemia....Pages 175-185
Nucleotide excision repair and anti-cancer chemotherapy....Pages 187-201
Protein kinases and multidrug resistance....Pages 203-224
New insights into the kinetic resistance to anticancer agents....Pages 225-235
The extended-MDR phenotype....Pages 237-247
Role of oxygenation and vascularization in drug resistance....Pages 249-256
Transcriptional regulation of MDR genes....Pages 257-269
Cytokine-mediated reversal of multidrug resistance....Pages 271-282
The role of oncogenes in drug resistance....Pages 283-292
Apoptosis resistance in tumor cells....Pages 293-308
Regulation of caspase activation in apoptosis: implications for transformation and drug resistance....Pages 309-320
Regulation of keratin and integrin gene expression in cancer and drug resistance....Pages 321-344

---

Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.
Content:
Front Matter....Pages i-xi
P-glycoprotein structure and evolutionary homologies....Pages 1-30
Molecular analysis of the multidrug transporter, P-glycoprotein....Pages 31-60
Mutagenesis of the putative nucleotide-binding domains of the multidrug resistance associated protein (MRP). Analysis of the effect of these mutations on MRP mediated drug resistance and transport....Pages 61-69
Membrane topology of the human multidrug resistance-associated protein (MRP) and its homologs....Pages 71-79
A new aspect on glutathione-associated biological function of MRP/GS-X pump and its gene expression....Pages 81-93
Intracellular distribution of anthracyclines in drug resistant cells....Pages 95-111
Use of ribozymes and antisense oligodeoxynucleotides to investigate mechanisms of drug resistance....Pages 113-136
Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP....Pages 137-148
Topoisomerase I inhibitors and drug resistance....Pages 149-164
Mechanisms of resistance to alkylating agents....Pages 165-173
Drug resistance and DNA repair in leukaemia....Pages 175-185
Nucleotide excision repair and anti-cancer chemotherapy....Pages 187-201
Protein kinases and multidrug resistance....Pages 203-224
New insights into the kinetic resistance to anticancer agents....Pages 225-235
The extended-MDR phenotype....Pages 237-247
Role of oxygenation and vascularization in drug resistance....Pages 249-256
Transcriptional regulation of MDR genes....Pages 257-269
Cytokine-mediated reversal of multidrug resistance....Pages 271-282
The role of oncogenes in drug resistance....Pages 283-292
Apoptosis resistance in tumor cells....Pages 293-308
Regulation of caspase activation in apoptosis: implications for transformation and drug resistance....Pages 309-320
Regulation of keratin and integrin gene expression in cancer and drug resistance....Pages 321-344
....