Ebook: Glycoimmunology 2

The Jenner International Glycoimmunology Meetings have charted the rapid devel­ opment of glycobiology within the field of inflammation. In less than a decade, the science has grown from basically being involved in carbohydrate analysis to the understanding of how sugars are associated with inflammation and how they have potential as anti­ inflammatory therapeutics. The 4th Jenner International Glycoimmunology Meeting was re­ cently held in Loutraki, Greece, and set the scene for what promises to be an exciting future for the speciality. Discussion reflected the rapid advances glycobiology is making and ranged from the basic biochemistry of carbohydrate physiology to therapeutic trials utilizing synthetic sugars designed to block inflammatory responses. The meeting is summarized in considerable detail in this book which will provide the interested scientist and clinician with the essential up-to-date facts within the field of glyco­ immunology. Acknowledgments Many people have been involved in ensuring the success of the Jenner Glycoimmu­ nology Meetings but none more so than my secretary Susan Henderson who has borne the brunt of all four meetings and is currently preparing for the 5th.

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The second installment of this outstanding treatise constitutes a single source for the rapid advances in glycobiology, from the basic biochemistry of carbohydrate physiology, to therapeutic trials using synthetic sugars designed to block inflammatory responses.
Subjects are arranged in sections on -- glycobiology basics -- oligosaccharides and protein recognition -- oligosaccharides and biological function -- glycosylation and inflammation -- glycosylation and disease -- glycotherapeutics

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The second installment of this outstanding treatise constitutes a single source for the rapid advances in glycobiology, from the basic biochemistry of carbohydrate physiology, to therapeutic trials using synthetic sugars designed to block inflammatory responses.
Subjects are arranged in sections on -- glycobiology basics -- oligosaccharides and protein recognition -- oligosaccharides and biological function -- glycosylation and inflammation -- glycosylation and disease -- glycotherapeutics
Content:
Front Matter....Pages i-ix
Front Matter....Pages 1-1
Novel Pathways in Complex-Type Oligosaccharide Synthesis....Pages 3-7
Defective Glycosyltransferases are Not Good for Your Health....Pages 9-27
Probing Carbohydrate-Protein Interactions by High-Resolution NMR Spectroscopy....Pages 29-38
Front Matter....Pages 39-39
The Structure of a Human Rheumatoid Factor Bound to IgG Fc....Pages 41-50
Carbohydrate Recognition Systems in Innate Immunity....Pages 51-54
Biosynthesis of Sulfated L-Selectin Ligands in Human High Endothelial Venules (HEV)....Pages 55-62
Endothelial Sialyl Lewis X as a Crucial Glycan Decoration on L-Selectin Ligands....Pages 63-73
Role of Lectin-Glycoconjugate Recognitions in Cell-Cell Interactions Leading to Tissue Invasion....Pages 75-82
Front Matter....Pages 83-83
Protein O-GlcNAcylation: Potential Mechanisms for the Regulation of Protein Function....Pages 85-94
A Longitudinal Study of Glycosylation of a Human IgG3 Paraprotein in a Patient with Multiple Myeloma....Pages 95-103
The Role of the Lectin Calnexin in Conformation Independent Binding to N-Linked Glycoproteins and Quality Control....Pages 105-116
Front Matter....Pages 117-117
Immunodetection of Glycosyltransferases: Prospects and Pitfalls....Pages 119-132
Cytokine and Protease Glycosylation as a Regulatory Mechanism in Inflammation and Autoimmunity....Pages 133-143
Occurrence and Possible Function of Inflammation-Induced Expression of Sialyl Lewis-X on Acute-Phase Proteins....Pages 145-150
Front Matter....Pages 151-151
The Glycosylation of the Complement Regulatory Protein, Human Erythrocyte CD59....Pages 153-162
Glycosylation and Rheumatic Disease....Pages 163-173
IgA Glycosylation in IgA Nephropathy....Pages 175-183
Oligosaccharide Profiling of Acute-Phase Proteins: A Possible Strategy Towards Better Markers in Disease....Pages 185-194
The Role of N-Linked Glycosylation in the Secretion of Hepatitis B Virus....Pages 195-205
Role of Glycan Processing in Hepatitis B Virus Envelope Protein Trafficking....Pages 207-216
Front Matter....Pages 217-217
Combinatorial Carbohydrate Chemistry....Pages 219-236
Bacterial Lipopolysaccharides: Candidate Vaccines to Prevent Neisseria Meningitidis and Haemophilus Influenzae Infections....Pages 237-243
Development of Double Copy Dicistronic Retroviral Vectors for Transfer and Expression of Glycosyltransferase Genes....Pages 245-250
Oligosaccharide Epitope Diversity and Therapeutic Potential....Pages 251-260
The Group B Streptococcal Capsular Carbohydrate: Immune Response and Molecular Mimicry....Pages 261-269
Back Matter....Pages 271-274

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The second installment of this outstanding treatise constitutes a single source for the rapid advances in glycobiology, from the basic biochemistry of carbohydrate physiology, to therapeutic trials using synthetic sugars designed to block inflammatory responses.
Subjects are arranged in sections on -- glycobiology basics -- oligosaccharides and protein recognition -- oligosaccharides and biological function -- glycosylation and inflammation -- glycosylation and disease -- glycotherapeutics
Content:
Front Matter....Pages i-ix
Front Matter....Pages 1-1
Novel Pathways in Complex-Type Oligosaccharide Synthesis....Pages 3-7
Defective Glycosyltransferases are Not Good for Your Health....Pages 9-27
Probing Carbohydrate-Protein Interactions by High-Resolution NMR Spectroscopy....Pages 29-38
Front Matter....Pages 39-39
The Structure of a Human Rheumatoid Factor Bound to IgG Fc....Pages 41-50
Carbohydrate Recognition Systems in Innate Immunity....Pages 51-54
Biosynthesis of Sulfated L-Selectin Ligands in Human High Endothelial Venules (HEV)....Pages 55-62
Endothelial Sialyl Lewis X as a Crucial Glycan Decoration on L-Selectin Ligands....Pages 63-73
Role of Lectin-Glycoconjugate Recognitions in Cell-Cell Interactions Leading to Tissue Invasion....Pages 75-82
Front Matter....Pages 83-83
Protein O-GlcNAcylation: Potential Mechanisms for the Regulation of Protein Function....Pages 85-94
A Longitudinal Study of Glycosylation of a Human IgG3 Paraprotein in a Patient with Multiple Myeloma....Pages 95-103
The Role of the Lectin Calnexin in Conformation Independent Binding to N-Linked Glycoproteins and Quality Control....Pages 105-116
Front Matter....Pages 117-117
Immunodetection of Glycosyltransferases: Prospects and Pitfalls....Pages 119-132
Cytokine and Protease Glycosylation as a Regulatory Mechanism in Inflammation and Autoimmunity....Pages 133-143
Occurrence and Possible Function of Inflammation-Induced Expression of Sialyl Lewis-X on Acute-Phase Proteins....Pages 145-150
Front Matter....Pages 151-151
The Glycosylation of the Complement Regulatory Protein, Human Erythrocyte CD59....Pages 153-162
Glycosylation and Rheumatic Disease....Pages 163-173
IgA Glycosylation in IgA Nephropathy....Pages 175-183
Oligosaccharide Profiling of Acute-Phase Proteins: A Possible Strategy Towards Better Markers in Disease....Pages 185-194
The Role of N-Linked Glycosylation in the Secretion of Hepatitis B Virus....Pages 195-205
Role of Glycan Processing in Hepatitis B Virus Envelope Protein Trafficking....Pages 207-216
Front Matter....Pages 217-217
Combinatorial Carbohydrate Chemistry....Pages 219-236
Bacterial Lipopolysaccharides: Candidate Vaccines to Prevent Neisseria Meningitidis and Haemophilus Influenzae Infections....Pages 237-243
Development of Double Copy Dicistronic Retroviral Vectors for Transfer and Expression of Glycosyltransferase Genes....Pages 245-250
Oligosaccharide Epitope Diversity and Therapeutic Potential....Pages 251-260
The Group B Streptococcal Capsular Carbohydrate: Immune Response and Molecular Mimicry....Pages 261-269
Back Matter....Pages 271-274
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