Ebook: The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity

Antibodies are crucial to the fine specificity of the immune system. An effective functioning of these molecules requires interaction with immune cells. Receptors for antibodies, Fc receptors, provide this critical link between the humoral and cellular branches of the immune system. This book presents a comprehensive overview of the different Fc receptors currently recognized. The first part of the book contains state-of-the-art overviews on the biological role of FcR. The latest information on FcR heterogeneity, FcR physiology, FcR-ligand recognition, their crucial coordinating role in immunity, interactions with other immunoreceptors, and the role of FcR in immunoglobulin transport and catabolism are discussed. The clinical importance of FcR is developed in the second part of the book. The well-recognized roles of FcR in allergy, inflammation, infectious diseases, autoimmune disorders, and immunotherapeutic importance are reviewed. The information in this book is easily accessible and should be helpful for researchers and clinical specialists as a convenient overview of the field, as well as a comprehensive introduction for students starting in this area of research.

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Content:
Front Matter....Pages i-xv
Introduction to the field....Pages 1-7
Front Matter....Pages 9-9
Molecular basis for the interaction of Fc receptors with immunoglobulins....Pages 11-35
Fc receptor genetics and the manipulation of genes in the study of FcR biology....Pages 37-48
Commentary....Pages 49-50
The polymeric immunoglobulin receptor....Pages 51-62
Multiple roles of FcRn....Pages 63-71
Signals initiated by the high affinity FcR for IgE....Pages 73-82
Phagocyte Fc receptors for IgG....Pages 83-93
Human IgA Fc receptors (Fc?R)....Pages 95-107
Platelet Fc receptors for IgG and IgE....Pages 109-117
Polymorphisms of Fc?RIIIa on NK cells and macrophages....Pages 119-134
Cooperation between IgG Fc receptors and complement receptors in host defence....Pages 135-140
Commentary....Pages 141-149
Fc?R and IgG-mediated negative regulation of immune responses....Pages 151-154
Fc?R on T cells....Pages 155-167
Role of IgG and IgE FcR in antigen presentation....Pages 169-183
Structure and function of CD23....Pages 185-194
Commentary on FcR regulation of development and function of the immune system....Pages 195-206
Front Matter....Pages 207-211
The role and use of recombinant receptors in the investigation and control of antibody-induced inflammation....Pages 213-213
Front Matter....Pages 215-231
FcR and autoimmunity....Pages 213-213
Heparin-induced thrombocytopenia as a model for Fc?RII-mediated disease....Pages 233-248
Fc? receptor polymorphisms: clinical aspects....Pages 249-266
Soluble Fc?R, a biological perspective....Pages 267-278
Fc?R-directed immunotherapies....Pages 279-290
The rewards of conversion to ‘FcRism’....Pages 291-305
Fc receptors: historical perspectives and a look to the future....Pages 307-309
Back Matter....Pages 311-313
....Pages 315-323