Ebook: The Biology of Tumors

The Ninth Annual Pezcoller Symposium entitled "The Biology of Tumors" was held in Rovereto, Italy, June 4-7, 1997. It focused on the genetic mechanisms underlying het­ erogeneity of tumor cell populations and tumor cell differentiation, on interactions be­ tween tumor cells and cells of host defenses, and the mechanisms of angiogenesis. With presentations at the cutting edge of progress and stimulating discussions, this symposium addressed issues related to phenomena concerned with cell regulation and cell interactions as determined by activated genes through the appropriate and timely media­ tion of gene products. Important methodologies that would allow scientists to measure dif­ ferentially genes and gene products and thus validate many of the mechanisms of control currently proposed were considered, as were the molecular basis of tumor recognition by the immune system, interactions between cells and molecular mechanisms of cell regula­ tion as they are affected by or implemented through these interactions. The molecular and cellular mechanisms of tumor vascularization were also discussed. It was recognized that angiogenesis provides a potential site of therapeutic intervention and this makes it even more important to understand the mechanisms underlying it. We wish to thank the participants in the symposium for their substantial contribu­ tions and their participation in the spirited discussions that followed. We would also like to thank Drs.

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Content:
Front Matter....Pages i-xi
The Role for ink4a in Melanoma Pathogenesis....Pages 1-14
Identification and Characterization of Collaborating Oncogenes in Compound Mutant Mice....Pages 15-30
The Transcription Factor B-Myb is Phosphorylated and Activated by Cyclin A/Cdk2....Pages 31-41
Distinct Dynamics and Regulatory Signal Transduction of Cell Migration....Pages 43-49
Genomic Instability in Sporadic Colorectal Cancer....Pages 51-56
APC and the Early Events of Colon Cancer....Pages 57-64
Genome Scanning and Gene Discovery in Breast and Ovarian Cancer....Pages 65-72
Failure of Tumor Immunity Resulting from Inaccessibility of Activated Lymphocytes to Solid Tumors....Pages 73-84
Deciphering Molecular Circuitry Using High-Density DNA Arrays....Pages 85-108
Use of cDNA Microarrays to Assess DNA Gene Expression Patterns in Cancer....Pages 109-116
EH, a Novel Protein....Pages 117-125
Deregulation of Cyclin D1 in Cancer....Pages 127-143
Dysregulation of Programmed Cell Death in Cancer toward a Molecular Understanding of Bcl-2....Pages 145-171
Characterization of Antigens Recognized by T Cells on Human Tumors....Pages 173-183
Identification of Human Tumor Antigens Using the B-Cell Repertoire....Pages 185-198
T Cell Tolerance versus Tumor Immunity or Autoimmunity....Pages 199-212
Manipulation of T Cell Activation in the Anti-Tumor Immune Response....Pages 213-222
General Discussion....Pages 223-230
Cytokines and Tumor Immunogenicity....Pages 231-247
T-Cell and NK-Mediated Surveillance of Cancer....Pages 249-271
Regulation of Leukocyte-Endothelial Cell Interactions in Tumor Immunity....Pages 273-286
Role of Endothelial versus Smooth Muscle Cells in Blood Vessel Formation....Pages 287-303
The Role of Vascular Endothelial Growth Factor in Tumor Angiogenesis....Pages 305-318
Tumor Microcirculation....Pages 319-345
Back Matter....Pages 347-351

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Content:
Front Matter....Pages i-xi
The Role for ink4a in Melanoma Pathogenesis....Pages 1-14
Identification and Characterization of Collaborating Oncogenes in Compound Mutant Mice....Pages 15-30
The Transcription Factor B-Myb is Phosphorylated and Activated by Cyclin A/Cdk2....Pages 31-41
Distinct Dynamics and Regulatory Signal Transduction of Cell Migration....Pages 43-49
Genomic Instability in Sporadic Colorectal Cancer....Pages 51-56
APC and the Early Events of Colon Cancer....Pages 57-64
Genome Scanning and Gene Discovery in Breast and Ovarian Cancer....Pages 65-72
Failure of Tumor Immunity Resulting from Inaccessibility of Activated Lymphocytes to Solid Tumors....Pages 73-84
Deciphering Molecular Circuitry Using High-Density DNA Arrays....Pages 85-108
Use of cDNA Microarrays to Assess DNA Gene Expression Patterns in Cancer....Pages 109-116
EH, a Novel Protein....Pages 117-125
Deregulation of Cyclin D1 in Cancer....Pages 127-143
Dysregulation of Programmed Cell Death in Cancer toward a Molecular Understanding of Bcl-2....Pages 145-171
Characterization of Antigens Recognized by T Cells on Human Tumors....Pages 173-183
Identification of Human Tumor Antigens Using the B-Cell Repertoire....Pages 185-198
T Cell Tolerance versus Tumor Immunity or Autoimmunity....Pages 199-212
Manipulation of T Cell Activation in the Anti-Tumor Immune Response....Pages 213-222
General Discussion....Pages 223-230
Cytokines and Tumor Immunogenicity....Pages 231-247
T-Cell and NK-Mediated Surveillance of Cancer....Pages 249-271
Regulation of Leukocyte-Endothelial Cell Interactions in Tumor Immunity....Pages 273-286
Role of Endothelial versus Smooth Muscle Cells in Blood Vessel Formation....Pages 287-303
The Role of Vascular Endothelial Growth Factor in Tumor Angiogenesis....Pages 305-318
Tumor Microcirculation....Pages 319-345
Back Matter....Pages 347-351
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