Ebook: Endothelin Receptors and Signaling Mechanisms

This book focuses on the wide variety of intracellular events that occur as a result of endothelin receptor activation. This includes a discussion of the various pathways by which endothelin activates Ca2+ signals from several intra- and extracellular sources and the effects of endothelin on ion channels and membrane function. In addition, the mechanisms by which endothelin influences the ion transport within the renal epithelium are covered, as well as the signal transduction pathways activated by endothelin in both cardiac tissue and vascular smooth muscle.

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This book focuses on the wide variety of intracellular events that occur as a result of endothelin receptor activation. This includes a discussion of the various pathways by which endothelin activates Ca2+ signals from several intra- and extracellular sources and the effects of endothelin on ion channels and membrane function. In addition, the mechanisms by which endothelin influences the ion transport within the renal epithelium are covered, as well as the signal transduction pathways activated by endothelin in both cardiac tissue and vascular smooth muscle.
Content:
Front Matter....Pages i-xii
Introduction to the Endothelin System....Pages 1-2
Endothelin Receptors and Receptor Antagonists....Pages 3-15
Novel Endothelin Receptors....Pages 17-21
“Sticky” Conundrums in the Endothelin System: Unique Binding Characteristics of Receptor Agonists and Antagonists....Pages 23-40
Functional Coordination and Cooperation Between Endothelin and Nitric Oxide Systems in Vascular Regulation....Pages 41-66
Molecular and Structural Biology of Endothelin Receptors....Pages 67-88
Cytokine Regulation of Endothelin Action....Pages 89-100
Endothelin Modulation of Renal Sodium and Water Transport....Pages 101-114
Endothelin and Ion Channels....Pages 115-129
Endothelin and Calcium Signaling....Pages 131-146
Endothelin Regulation of Cardiac Contractility: Signal Transduction Pathways....Pages 147-161
Endothelin Signaling to the Nucleus: Regulation of Gene Expression and Phenotype....Pages 163-176
Mechanisms of Endothelin-Induced Mitogenesis and Activation of Stress Response Protein Kinases....Pages 177-215
Back Matter....Pages 217-224

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This book focuses on the wide variety of intracellular events that occur as a result of endothelin receptor activation. This includes a discussion of the various pathways by which endothelin activates Ca2+ signals from several intra- and extracellular sources and the effects of endothelin on ion channels and membrane function. In addition, the mechanisms by which endothelin influences the ion transport within the renal epithelium are covered, as well as the signal transduction pathways activated by endothelin in both cardiac tissue and vascular smooth muscle.
Content:
Front Matter....Pages i-xii
Introduction to the Endothelin System....Pages 1-2
Endothelin Receptors and Receptor Antagonists....Pages 3-15
Novel Endothelin Receptors....Pages 17-21
“Sticky” Conundrums in the Endothelin System: Unique Binding Characteristics of Receptor Agonists and Antagonists....Pages 23-40
Functional Coordination and Cooperation Between Endothelin and Nitric Oxide Systems in Vascular Regulation....Pages 41-66
Molecular and Structural Biology of Endothelin Receptors....Pages 67-88
Cytokine Regulation of Endothelin Action....Pages 89-100
Endothelin Modulation of Renal Sodium and Water Transport....Pages 101-114
Endothelin and Ion Channels....Pages 115-129
Endothelin and Calcium Signaling....Pages 131-146
Endothelin Regulation of Cardiac Contractility: Signal Transduction Pathways....Pages 147-161
Endothelin Signaling to the Nucleus: Regulation of Gene Expression and Phenotype....Pages 163-176
Mechanisms of Endothelin-Induced Mitogenesis and Activation of Stress Response Protein Kinases....Pages 177-215
Back Matter....Pages 217-224
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