Ebook: Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2: Part A

Over one hundred contributions detail advances in the molecular and cellular biology of eicosanoid production, as well as their role in signal transduction. One of the most exciting developments explored within this collection of articles is the expression of the novel isoform of cyclooxygenase (cox-2), which may play a large role in the development of anti-inflammatory drugs.

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Over one hundred contributions detail advances in the molecular and cellular biology of eicosanoid production, as well as their role in signal transduction. One of the most exciting developments explored within this collection of articles is the expression of the novel isoform of cyclooxygenase (cox-2), which may play a large role in the development of anti-inflammatory drugs.

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Over one hundred contributions detail advances in the molecular and cellular biology of eicosanoid production, as well as their role in signal transduction. One of the most exciting developments explored within this collection of articles is the expression of the novel isoform of cyclooxygenase (cox-2), which may play a large role in the development of anti-inflammatory drugs.
Content:
Front Matter....Pages i-xxv
Front Matter....Pages 1-1
Regulation of Phosphoinositide Phospholipases by G-Proteins....Pages 3-8
The Effects of Group II Phospholipase A2 on Ras-Induced Metastasis....Pages 9-17
Activation of Ca2+-Sensitive Cytosolic Phospholipase A2 (cPLA2) in Human Platelets....Pages 19-24
Involvement of Reactive Oxygen Species in Phospholipase A2 Activation: Inhibition of Protein Tyrosine Phosphatases and Activation of Protein Kinases....Pages 25-30
High Molecular Weight Phospholipase A2: Its Occurrence and Quantification in Human Colon Cancer and Normal Mucosa....Pages 31-37
Front Matter....Pages 39-39
Activation of 5-Lipoxygenase in Whole Polymorphonuclear Leukocytes by Arachidonic Acid: Evidence of Cytosolic Active Enzyme....Pages 41-45
Intracellular Distribution, Activity, and Ca2+-Dependent Translocation of 12-Lipoxygenase in Lewis Lung Tumor Cells....Pages 47-56
Cloning and Sequencing of Prostaglandin H Synthetase from Rat Tracheal Epithelial Cells: Structural Evidence that a TPA Regulated mRNA Codes for the Rat Ortholog of Murine PHS-1....Pages 57-64
Non-Enzymatic Rearrangement of Leukotriene A4 to 5-Keto-(7E,9E,11Z,14Z)-Eicosatetraenoic Acid in Aqueous Media....Pages 65-70
Bromoacetamido-Analogs of Indomethacin and Mefenamic Acid Affinity-Label Prostaglandin H2 Synthase at Two Sites....Pages 71-76
Regulation of Eicosanoid Synthesis in Liver Macrophages....Pages 77-84
Comparison of Arachidonic Acid Metabolism by Normal, Pre-Cancerous and Neoplastic Epithelial Cell Lines of the Upper Aerodigestive Tract....Pages 85-92
Induction of Prostaglandin Endoperoxide Synthase-1 (Cox-1) in a Human Promonocytic Cell Line by Treatment with the Differentiating Agent TPA....Pages 93-98
X-Ray Crystallographic Study of the Structure of Prostaglandin H Synthase....Pages 99-106
Properties of Prostacyclin Synthase....Pages 107-111
Regulation of Prostaglandin H Synthase-1 Gene Expression....Pages 113-119
Mammalian Arachidonate 12-Lipoxygenases....Pages 121-126
The Three-Dimensional Structure of Soybean Lipoxygenase-1: An Arachidonic Acid 15-Lipoxygenase....Pages 127-131
Purification and Characterization of the Epidermal 8(S)Lipoxygenase....Pages 133-138
Front Matter....Pages 139-144
The Effect of 5-Lipoxygenase-Activating Protein (Flap) on Substrate Utilization by 5-Lipoxygenase....Pages 39-39
Leukotriene A4 Hydrolase: Differential Inhibition of the Catalytic Activities by Divalent Cations....Pages 145-151
Regulation of 12(S)-Hete Production in Tumor Cells....Pages 153-157
Distribution of Cox-1 and Cox-2 in Normal and Inflamed Tissues....Pages 159-166
Examination of Prostaglandin H Synthase-1 Topology in the Endoplasmic Reticulum Membrane....Pages 167-170
Coordinate Regulation of the Inducible forms of Prostaglandin Synthase and Nitric Oxide Synthase in Fibroblasts and Macrophages....Pages 171-175
Molecular Cloning of Prostacyclin Synthase from Bovine Endothelial Cells....Pages 177-182
Interaction of PGH Synthase Isozymes-1 and -2 with Nonsteroidal Anti-Inflammatory Drugs....Pages 183-187
Front Matter....Pages 189-196
Dual Effect of Propranolol on the Human Platelet Activation by Thrombin: Potentiation of Free Intracellular Ca2+ Mobilization and Inhibition of Phospholipase D Activity....Pages 197-197
Molecular Diversity of Prostanoid Receptors; Subtypes and Isoforms of Prostaglandin E Receptor....Pages 199-205
Molecular Characterization and Physiological Functions of PAF Receptors....Pages 207-213
Identification of the FP-Receptor as a Discrete Entity by Radioligand Binding in Biosystems that Exhibit Different Functional Rank Orders of Potency in Response to Prostanoids....Pages 215-221
Modification on Ligand Binding to TXA2/PGH2 Receptors by Diethylpyrocarbonate....Pages 223-227
Prostaglandin Receptors Involved in Inflammatory Events....Pages 229-233
LTB4 Receptor Antagonists Exacerbate T Lymphocyte-Mediated Delayed Hypersensitivity in Guinea Pigs....Pages 235-240
Isolation and Cloning of Human Peroxisome Proliferator Activated Receptor Gamma CDNA....Pages 241-245
Structure and Localization of the Rabbit Prostaglandin EP3 Receptor....Pages 247-251
Prostaglandin Regulation of Gene Expression and Growth in Normal and Malignant Tissues....Pages 253-260
Distinct Signaling Pathways Mediate Induction of c-fos by PGE2 in Glomerular Mesangial Cells....Pages 261-268
Front Matter....Pages 269-278
Cytosolic 12(S)-Hydroxy-5,8,10,14-Eicosatetraenoic Acid Binding Sites in Carcinoma Cells....Pages 279-286
Front Matter....Pages 197-197
Dag Second Messengers: Molecular Switches and Growth Control....Pages 287-293
Sphingolipid Second Messengers: Tumor Suppressor Lipids....Pages 295-295
The Role of Protein Kinase C in Signal Transduction, Growth Control and Lipid Metabolism....Pages 297-303
Tumor Responsiveness to the Metastasis-Stimulatory Effects of Prostaglandin E2 is Restricted by Protein Phosphatases....Pages 305-312
Interactions Between Specific Phosphoproteins During Modulation of Prostacyclin Secretion in Cultured Bovine Aortic Endothelial Cells....Pages 313-321
The Role of Lipid Peroxidation Products in the Regulation of Protein Kinase C Activity in Vitro....Pages 323-328
Role of Protein Kinase C and Phosphatases in 12(S)-Hete-Induced Tumor Cell Cytoskeletal Reorganization....Pages 329-337
Front Matter....Pages 339-348
Hepoxilin A3 Inhibits Agonist-Evoked Rise in Free Intracellular Calcium in Human Neutrophils....Pages 349-361
The Discovery of LY293111, a Novel, Potent and Orally Active Leukotriene B4 Receptor Antagonist of the Biphenylphenol Class....Pages 363-363
Inhibition of Leukotriene B4 (LTB4) in Human Neutrophils by L-Threo-Dihydrosphingosine....Pages 365-373
Front Matter....Pages 375-380
Aspirin and Gastrointestinal Cancer....Pages 381-386
Monohydroxylated Fatty Acids in Mouse Epidermis Papilloma Quantification and Stereochemical Characterization....Pages 387-392
Negative Growth Regulation of Oncogene-Transformed Mammary Epithelial Cells by Tumor Inhibitors....Pages 393-393
Different Expression of Prostaglandin-H Synthase Isozymes and Lipoxygenases During Multistage Carcinogenesis in Mouse Skin....Pages 395-402
Expression of Two cPLA2 Isoforms in Mouse Epidermis in Vivo....Pages 403-407
Regulation of Arachidonic Acid Release and Metabolism by Tumor Promoters....Pages 409-418
Effect of the Peroxisome Proliferators Ciprofibrate and Perfluorodecanoic Acid on Eicosanoid Concentrations in Rat Liver....Pages 419-424
Front Matter....Pages 425-431
A Mitogenic and Hormonal Signalling Network Regulate Mammalian Cell Division Commitment Time....Pages 433-438
Front Matter....Pages 439-445
Growth Inhibitory Effects of Thromboxane Antagonists on Breast Cancer Cell Lines: A Preliminary Study....Pages 447-447
The Rise and Fall of Ceramide and 1,2-Diacylglycerol (DAG): Modulation by Transforming Growth Factor-?1 (TGF?1) and by Epidermal Growth Factor (EGF)....Pages 449-454
Antioxidant Defence Mechanisms and PGE Secretion by Different Types of Transformed and Tumor Cells: In Vivo Selective Advantages....Pages 447-447
The Relationship Between Farnesylation and Carcinogenesis: The Effect of Lovastatin on Fibroblast Proliferation....Pages 455-460
Eicosanoid Production and Growth Regulation in Rat Intestinal Epithelial Cells....Pages 461-472
Role of Archidonic Acid and Linoleic Acid Metabolism in Epidermal Growth Factor Initiated Proliferation of Syrian Hamster Embryo Fibroblasts....Pages 473-477
Phenylacetate and Phenylbutyrate as Novel, Nontoxic Differentiation Inducers....Pages 479-486
Structural Requirements for Enhancement of EGF-Dependent DNA Synthesis by Oxygenated Metabolltes of Linoleic Acid....Pages 487-493
Decreased DNA Synthesis in SCC-25 Cells with ETYA and SC41661....Pages 495-500
Liver Fatty Acid Binding Protein and Mitogenesis in Transfected Hepatoma Cells....Pages 501-505
Induction of 12-Lipoxygenase Expression by Epidermal Growth Factor is Mediated by Protein Kinase C in A431 Cells....Pages 507-512
Prostaglandin F2? (PGF2?) Triggers Protein Kinase C (PKC) and Tyrosine Kinase Activity in Cultured Mammalian Cells....Pages 513-516
Mechanisms of the Selective Cytotoxic Actions of Certain Essential Fatty Acids....Pages 517-524
Eicosanoids, Cancer Metastasis, and Gene Regulation: An Overview....Pages 525-529
....Pages 531-538