Ebook: Sphingolipid-Mediated Signal Transduction

Lipid-derived molecules are increasingly appreciated as key regulators of cell responses and signal transduction. Sphingolipid-derived bioactive molecules are emerging as critical regulators of some of the most exciting and, until recently, poorly-understood areas of biology such as growth suppression, programmed cell death and tumor invasion. Written by leading investigators in these areas of study, this book presents a thorough, current and accessible review of how sphingolipids function to regulate these important activities.

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Content:
Front Matter....Pages i-xvii
Introduction and Overview....Pages 1-18
Ceramide: A Stress Response Mediator Involved in Growth Suppression....Pages 19-34
Ceramide and Inflammation....Pages 35-51
A Role for Ceramide in Meiosis....Pages 53-60
Ceramide, Aging and Cellular Senescence....Pages 61-75
Ceramide, a Mediator of Cytosine Arabinoside Induced Apoptosis....Pages 77-90
The Use of Cerebroside Synthase Inhibitors as Probes for Assessing the Metabolism and Function of Sphingolipids....Pages 91-101
Role of Sphingolipids in Regulating the Phospholipase D Pathway and Cell Division....Pages 103-120
Sphingosine-1-Phosphate: Member of a New Class of Lipid Second Messengers....Pages 121-135
Functional Roles of Glycosphingolipids and Sphingolipids in Signal Transduction....Pages 137-158
Ceramide Synthase and Ceramidases in the Regulation of Sphingoid Base Metabolism....Pages 159-172
Ceramidase and Signal Transduction....Pages 173-181
Back Matter....Pages 183-188

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Content:
Front Matter....Pages i-xvii
Introduction and Overview....Pages 1-18
Ceramide: A Stress Response Mediator Involved in Growth Suppression....Pages 19-34
Ceramide and Inflammation....Pages 35-51
A Role for Ceramide in Meiosis....Pages 53-60
Ceramide, Aging and Cellular Senescence....Pages 61-75
Ceramide, a Mediator of Cytosine Arabinoside Induced Apoptosis....Pages 77-90
The Use of Cerebroside Synthase Inhibitors as Probes for Assessing the Metabolism and Function of Sphingolipids....Pages 91-101
Role of Sphingolipids in Regulating the Phospholipase D Pathway and Cell Division....Pages 103-120
Sphingosine-1-Phosphate: Member of a New Class of Lipid Second Messengers....Pages 121-135
Functional Roles of Glycosphingolipids and Sphingolipids in Signal Transduction....Pages 137-158
Ceramide Synthase and Ceramidases in the Regulation of Sphingoid Base Metabolism....Pages 159-172
Ceramidase and Signal Transduction....Pages 173-181
Back Matter....Pages 183-188
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