Ebook: Chemistry and Biology of Serpins

`The editors have succeeded in producing a volume of work which provides many answers to questions, asked and unasked, about a critically important field of biologic research. It should be in the library of any scientist with an interest in human physiology; it would be useful to many other researchers as well.'
Chemtracts - Biochemistry and Molecular Biology, 12:10 (1999)

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Introduction: Serpins: From the Way It Was to the Way It Is; J.Travis. Serpins: A Mechanistic Class of Their Own; S.R. Stone, et al.Coagulation: Antithrombin-A Bloody Important Serpin; I.Bjork, S.T. Olson. Heparin Cofactor II; D.M. Tollefsen.Neurobiology and Cancer: Regulation of Neurons and Astrocytes by Thrombin and Protease Nexin-l: Relationship to Brain Injury; D.D. Cunningham, F.M. Donovan. Maspin: A Tumor Suppressing Serpin; R.Sager, et al.. Fibrinolysis: The Role of Reactive-Center Loop Mobility in the Serpin Inhibitory Mechanism; D.A. Lawrence. Substrate Specificity of Tissue Type Plasminogen Activator; E.L. Madison.Development and Reproduction: Biology of Progesterone-Induced Uterine Serpins; P.J. Hansen, W.-J. Liu. Serpins from an Insect, Manduca sexta; M.R. Kanost, H. Jiang.Inflammation: Serpins and Programmed Cell Death; G.S. Salvesen.Noninhibitor Serpins: Structure-Function Studies on PEDF: A Noninhibitory Serpin with Neurotropic Activity; S.P. Becerra.Abstracts: Coagulation, Neurobiology and Cancer. Fibrinolysis, Development and Reproduction. Inflammation and Noninhibitor Serpins. 10 Additional Articles. Index.

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Introduction: Serpins: From the Way It Was to the Way It Is; J.Travis. Serpins: A Mechanistic Class of Their Own; S.R. Stone, et al.Coagulation: Antithrombin-A Bloody Important Serpin; I.Bjork, S.T. Olson. Heparin Cofactor II; D.M. Tollefsen.Neurobiology and Cancer: Regulation of Neurons and Astrocytes by Thrombin and Protease Nexin-l: Relationship to Brain Injury; D.D. Cunningham, F.M. Donovan. Maspin: A Tumor Suppressing Serpin; R.Sager, et al.. Fibrinolysis: The Role of Reactive-Center Loop Mobility in the Serpin Inhibitory Mechanism; D.A. Lawrence. Substrate Specificity of Tissue Type Plasminogen Activator; E.L. Madison.Development and Reproduction: Biology of Progesterone-Induced Uterine Serpins; P.J. Hansen, W.-J. Liu. Serpins from an Insect, Manduca sexta; M.R. Kanost, H. Jiang.Inflammation: Serpins and Programmed Cell Death; G.S. Salvesen.Noninhibitor Serpins: Structure-Function Studies on PEDF: A Noninhibitory Serpin with Neurotropic Activity; S.P. Becerra.Abstracts: Coagulation, Neurobiology and Cancer. Fibrinolysis, Development and Reproduction. Inflammation and Noninhibitor Serpins. 10 Additional Articles. Index.
Content:
Front Matter....Pages i-xix
Serpins....Pages 1-4
Serpins....Pages 5-15
Antithrombin....Pages 17-33
Heparin Cofactor II....Pages 35-44
PCI: Protein C Inhibitor?....Pages 45-54
Molecular Basis for the Resistance of Fibrin-Bound Thrombin to Inactivation by Heparin/Serpin Complexes....Pages 55-66
Regulation of Neurons and Astrocytes by Thrombin and Protease Nexin-1....Pages 67-75
Maspin....Pages 77-88
Proteases and Protease Inhibitors in Tumor Progression....Pages 89-97
The Role of Reactive-Center Loop Mobility in the Serpin Inhibitory Mechanism....Pages 99-108
Substrate Specificity of Tissue Type Plasminogen Activator....Pages 109-121
Plasminogen Activator Inhibitor Type-2....Pages 123-130
Of Mice and Men....Pages 131-141
Biology of Progesterone-Induced Uterine Serpins....Pages 143-154
The Significance of Serpins in the Regulation of Proteases in the Male Genital Tract....Pages 155-161
Serpins and Programmed Cell Death....Pages 163-176
C1 Inhibitor....Pages 177-183
Serp-1, A Poxvirus-Encoded Serpin, Is Expressed as a Secreted Glycoprotein that Inhibits the Inflammatory Response to Myxoma Virus Infection....Pages 185-194
Dysfunctional Variants and the Structural Biology of the Serpins....Pages 195-205
Structure-Function Studies on PEDF....Pages 207-222
Colligin, A Collagen Binding Serpin....Pages 223-237
Coagulation, Neurobiology, and Cancer....Pages 239-245
Fibrinolysis, Development, and Reproduction....Pages 247-280
Inflammation and Noninhibitor Serpins....Pages 281-305
Back Matter....Pages 307-339
....Pages 341-358