Ebook: Molecular Mechanisms of Signalling and Membrane Transport: Proceedings of the NATO Study Institute on Molecular Mechanisms of Signalling and Targeting, held on the Island of Spetsai, Greece, August 18–30, 1996

This volume provides a compilation of the main principles of signal transduction mechanisms. The reader will become familiar with the most recent developments on:
- the structure and function of heterotrimeric G-proteins and their receptors;
- the small GTPases Ras, Rho, Rab and Arf;
- EGF receptor, Ca2+ and protein kinase C;
- phosphoinositide kinases (PI-3 kinases);
- phospholipases C and D;
- ceramides and possible modulators of apoptosis;
- transcription factors and gene activation;
- multidrug resistance transporters.

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This volume provides a compilation of the main principles of signal transduction mechanisms. The reader will become familiar with the most recent developments on:
- the structure and function of heterotrimeric G-proteins and their receptors;
- the small GTPases Ras, Rho, Rab and Arf;
- EGF receptor, Ca2+ and protein kinase C;
- phosphoinositide kinases (PI-3 kinases);
- phospholipases C and D;
- ceramides and possible modulators of apoptosis;
- transcription factors and gene activation;
- multidrug resistance transporters.
Content:
Front Matter....Pages I-IX
Heterotrimeric Guanine Nucleotide Binding Proteins: Structure and Function....Pages 1-24
G protein coupled receptors: structure, functions and mutation....Pages 25-45
Heterologous Expression of G Protein-Coupled Receptors in Yeasts: an Approach to Facilitate Drug Discovery....Pages 47-62
The Role of Small GTPases in Signal Transduction....Pages 63-73
Small GTPases in the morphogenesis of yeast and plant cells....Pages 75-87
A role for G-protein ??-subunits in the secretory mechanism of rat peritoneal mast cells....Pages 89-98
Subcellular localisation of ARF1-regulated phospholipase D in HL60 cells....Pages 99-112
Electrophysiological Aspects of Growth Factor Signaling in NRK Fibroblasts: The Role of Intercellular Communication, Membrane Potential and Calcium....Pages 113-126
Cross-talk between calmodulin and protein kinase C....Pages 127-150
A function for Eps15 in EGF-receptor endocytosis?....Pages 151-161
Proteins, Sorted. The Secretory Pathway from the Endoplasmic Reticulum to the Golgi, and Beyond....Pages 163-174
The roles of PI3Ks in cellular regulation....Pages 175-188
Phosphatidylinositol Transfer Protein, Phosphoinositides and Cell Function....Pages 189-195
Receptor Regulation of Phospholipases C and D....Pages 197-209
Ceramide: A Central Regulator of the Cellular Response to Injury and Stress....Pages 211-223
Ceramide changes during FAS (CD95/APO-1) mediated programmed cell death are blocked with the ICE protease inhibitor zVAD.FMK....Pages 225-231
The structure, biosynthesis and function of GPI membrane anchors....Pages 233-245
Enzyme Assisted Synthetic Approaches to the Inositol Phospholipid Pathway....Pages 247-264
Coupling Signal Transduction to Transcription: The Nuclear Response to cAMP....Pages 265-279
Vitamin E and the Metabolic Antioxidant Network....Pages 281-304
The Molecular Basis for Pleiotropic Drug Resistance in the Yeast Saccharomyces Cerevisiae: Regulation of Expression, Intracellular Trafficking and Proteolytic Turnover of ATP Binding Cassette (ABC) Multidrug Resistance Transporters....Pages 305-317
Regulation of Carbon Metabolism in Bacteria....Pages 319-330
Back Matter....Pages 331-335

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This volume provides a compilation of the main principles of signal transduction mechanisms. The reader will become familiar with the most recent developments on:
- the structure and function of heterotrimeric G-proteins and their receptors;
- the small GTPases Ras, Rho, Rab and Arf;
- EGF receptor, Ca2+ and protein kinase C;
- phosphoinositide kinases (PI-3 kinases);
- phospholipases C and D;
- ceramides and possible modulators of apoptosis;
- transcription factors and gene activation;
- multidrug resistance transporters.
Content:
Front Matter....Pages I-IX
Heterotrimeric Guanine Nucleotide Binding Proteins: Structure and Function....Pages 1-24
G protein coupled receptors: structure, functions and mutation....Pages 25-45
Heterologous Expression of G Protein-Coupled Receptors in Yeasts: an Approach to Facilitate Drug Discovery....Pages 47-62
The Role of Small GTPases in Signal Transduction....Pages 63-73
Small GTPases in the morphogenesis of yeast and plant cells....Pages 75-87
A role for G-protein ??-subunits in the secretory mechanism of rat peritoneal mast cells....Pages 89-98
Subcellular localisation of ARF1-regulated phospholipase D in HL60 cells....Pages 99-112
Electrophysiological Aspects of Growth Factor Signaling in NRK Fibroblasts: The Role of Intercellular Communication, Membrane Potential and Calcium....Pages 113-126
Cross-talk between calmodulin and protein kinase C....Pages 127-150
A function for Eps15 in EGF-receptor endocytosis?....Pages 151-161
Proteins, Sorted. The Secretory Pathway from the Endoplasmic Reticulum to the Golgi, and Beyond....Pages 163-174
The roles of PI3Ks in cellular regulation....Pages 175-188
Phosphatidylinositol Transfer Protein, Phosphoinositides and Cell Function....Pages 189-195
Receptor Regulation of Phospholipases C and D....Pages 197-209
Ceramide: A Central Regulator of the Cellular Response to Injury and Stress....Pages 211-223
Ceramide changes during FAS (CD95/APO-1) mediated programmed cell death are blocked with the ICE protease inhibitor zVAD.FMK....Pages 225-231
The structure, biosynthesis and function of GPI membrane anchors....Pages 233-245
Enzyme Assisted Synthetic Approaches to the Inositol Phospholipid Pathway....Pages 247-264
Coupling Signal Transduction to Transcription: The Nuclear Response to cAMP....Pages 265-279
Vitamin E and the Metabolic Antioxidant Network....Pages 281-304
The Molecular Basis for Pleiotropic Drug Resistance in the Yeast Saccharomyces Cerevisiae: Regulation of Expression, Intracellular Trafficking and Proteolytic Turnover of ATP Binding Cassette (ABC) Multidrug Resistance Transporters....Pages 305-317
Regulation of Carbon Metabolism in Bacteria....Pages 319-330
Back Matter....Pages 331-335
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