Ebook: Proteome Research: New Frontiers in Functional Genomics

Recent advances in two-dimensional electrophoresis, protein microanalysis and bioinformatics have made the large-scale, systematic analysis of proteins and their post-translational modifications from any tissue or organism possible. This approach has acquired the name "Proteome Research", and can be considered as the core of functional genomics. The results of proteome analysis show which genes are expressed, how the protein products are modified, and how they interact, making proteome research of fundamental importance for the biologist, clinician, and pharmaceutical industry.

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Recent advances in two-dimensional electrophoresis, protein microanalysis and bioinformatics have made the large-scale, systematic analysis of proteins and their post-translational modifications from any tissue or organism possible. This approach has acquired the name "Proteome Research", and can be considered as the core of functional genomics. The results of proteome analysis show which genes are expressed, how the protein products are modified, and how they interact, making proteome research of fundamental importance for the biologist, clinician, and pharmaceutical industry.
Content:
Front Matter....Pages I-XVIII
Introduction to the Proteome....Pages 1-12
Two-Dimensional Electrophoresis: The State of the Art and Future Directions....Pages 13-34
Protein Identification in Proteome Projects....Pages 35-64
The Importance of Protein Co- and Post-Translational Modifications in Proteome Projects....Pages 65-91
Proteome Databases....Pages 93-148
Interfacing and Integrating Databases....Pages 149-175
Large-Scale Comparative Protein Modelling....Pages 177-186
Clinical and Biomedical Applications of Proteomics....Pages 187-219
Biological Applications of Proteomics....Pages 221-232
Conclusions....Pages 233-237
Back Matter....Pages 239-245

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Recent advances in two-dimensional electrophoresis, protein microanalysis and bioinformatics have made the large-scale, systematic analysis of proteins and their post-translational modifications from any tissue or organism possible. This approach has acquired the name "Proteome Research", and can be considered as the core of functional genomics. The results of proteome analysis show which genes are expressed, how the protein products are modified, and how they interact, making proteome research of fundamental importance for the biologist, clinician, and pharmaceutical industry.
Content:
Front Matter....Pages I-XVIII
Introduction to the Proteome....Pages 1-12
Two-Dimensional Electrophoresis: The State of the Art and Future Directions....Pages 13-34
Protein Identification in Proteome Projects....Pages 35-64
The Importance of Protein Co- and Post-Translational Modifications in Proteome Projects....Pages 65-91
Proteome Databases....Pages 93-148
Interfacing and Integrating Databases....Pages 149-175
Large-Scale Comparative Protein Modelling....Pages 177-186
Clinical and Biomedical Applications of Proteomics....Pages 187-219
Biological Applications of Proteomics....Pages 221-232
Conclusions....Pages 233-237
Back Matter....Pages 239-245
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