Ebook: Chemical Synthesis: Gnosis to Prognosis

Chemical Synthesis: Gnosis to Prognosis (XTUllKtl ~uv8eoTr ana TT) rVWOT) OTT) npaYVWOT)) " . . . . other things being equal, that field has the most merit which contributes most heavily to, and illuminates most brightly, its neighbouring scientific disciplines[l] One hundred scientists, a blend of students, industrialists, and academics from twenty countries gathered to circumscribe, understand, and elaborate this topic in the magical setting of Ravello, Italy. The mandate of this workshop? To survey existing knowledge, assess current work, and discuss the future directions of chemical synthesis as it impinges on three exciting interdisciplinary themes of science in the 1990's: bioactive molecules, man-made chemical materials, and molecular recognition. This tempting but inexact menu summoned diverse students and scientists who wished to seriously reflect upon, dissect, and eject ideas and own experiences into open debate on this topic, which is at a crossroad in internal evolution and impact on the life and material sciences. The group arrived from many directions and in various forms of transportation, matters soon forgotten, when it found itself in the village which nurtured Wagner's inspiration and set to work immediately to ponder the question which has received extensive thought, prediction, and caveat from illustrious chemists over a period of time [2], two of which, to the delight of all, in presence among the Lectures.

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This volume demonstrates that chemical synthesis is fully undeserving of the label `mature science'. Although chemists are increasingly able to provide some solutions in the construction of natural and biologically active products, synthesis is facing formidable challenges in the emerging areas of bioorganic chemistry, molecular biology, materials science and polymer science.
This unique book presents the lectures and discussions of an outstanding group of such interdisciplinary scientists. Unperturbed by excessive structure and time constraints, the group talked about the current status of their areas (gnosis) and mused on their future directions (prognosis). Individual lectures and panels led naturally to questions and discussion, expression of alternative points of view, and thought provoking suggestions. To the chemist who is increasingly aware of the breakdown of barriers in chemistry, biology and materials science, this book is a source of provocative thought and an arrow pointing to the central role of synthesis in the way chemistry impinges on scientific activity.

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This volume demonstrates that chemical synthesis is fully undeserving of the label `mature science'. Although chemists are increasingly able to provide some solutions in the construction of natural and biologically active products, synthesis is facing formidable challenges in the emerging areas of bioorganic chemistry, molecular biology, materials science and polymer science.
This unique book presents the lectures and discussions of an outstanding group of such interdisciplinary scientists. Unperturbed by excessive structure and time constraints, the group talked about the current status of their areas (gnosis) and mused on their future directions (prognosis). Individual lectures and panels led naturally to questions and discussion, expression of alternative points of view, and thought provoking suggestions. To the chemist who is increasingly aware of the breakdown of barriers in chemistry, biology and materials science, this book is a source of provocative thought and an arrow pointing to the central role of synthesis in the way chemistry impinges on scientific activity.
Content:
Front Matter....Pages i-xi
Asymmetric Synthesis : I - Fundamentals and Recent Advances II - Some Aspects of Asymmetric Catalysis with Transition - Metal Complexes....Pages 1-23
Addition of Enolates and Metalloalkyls to Imines. Stereospecific Synthesis of ?-Lactams, Amines, Aziridines and Aminols....Pages 25-60
Target-driven Organic Synthesis: Reflections on the Past, Prospects for the Future....Pages 61-90
Optically Active Transition Metal Compounds Containing Chiral Transition Metal Atoms....Pages 91-111
Biomimetic Chemistry....Pages 113-135
Design of Enzyme Inhibitors....Pages 137-173
Enantioselective Catalysis with Transition Metal Complexes....Pages 175-190
Directed Aromatic Metalation : A Continuing Education in Flatland Chemistry....Pages 191-221
As We Head into the 21st Century, Is there Still Value in Total Synthesis of Natural Products as a Research Endeavor?....Pages 223-243
Convergent Strategies for Synthetic Receptors....Pages 245-261
The Advancement of Radical-Based Synthetic Strategies: From Reagent Design to Polymer Modification....Pages 263-276
Templated Synthesis of Enzyme Mimics: How Far can We Go?....Pages 277-291
Towards a Chemical Etiology of the Natural Nucleic Acids’ Structure....Pages 293-340
Principles of Antibody Catalysis....Pages 341-359
New Homocalixarenes and Catenanes....Pages 361-379
Self-Assembly in Chemical Synthesis....Pages 381-401
Oligonucleotide-Directed Recognition of Double-Helical DNA....Pages 403-417
Can Enzyme Mimics Compete with Catalytic Antibodies?....Pages 419-428
Synthesis of Giant Modular Structures....Pages 429-452
Polymer Synthesis and Stereochemistry with Transition Metal Catalysts....Pages 453-473
Making Unnatural Products by Natural Means....Pages 475-510
Supramolecular Chemistry and Chemical Synthesis....Pages 511-524
Synthetic Approaches to Functional Polymers....Pages 525-548
Transduction of Molecular Interactions into Macroscopic Properties....Pages 549-563
Approaches to Synthesis Based on Non-Covalent Bonds....Pages 565-588
The Functionalization of Saturated Hydrocarbons by Gif Chemistry. Part 1. Use of Superoxide and of Hydrogen Peroxide. Part 2. Use of t-Butylhydroperoxide (TBHP)....Pages 589-599
Organic Synthesis and the Life Sciences....Pages 601-619
Back Matter....Pages 621-625

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This volume demonstrates that chemical synthesis is fully undeserving of the label `mature science'. Although chemists are increasingly able to provide some solutions in the construction of natural and biologically active products, synthesis is facing formidable challenges in the emerging areas of bioorganic chemistry, molecular biology, materials science and polymer science.
This unique book presents the lectures and discussions of an outstanding group of such interdisciplinary scientists. Unperturbed by excessive structure and time constraints, the group talked about the current status of their areas (gnosis) and mused on their future directions (prognosis). Individual lectures and panels led naturally to questions and discussion, expression of alternative points of view, and thought provoking suggestions. To the chemist who is increasingly aware of the breakdown of barriers in chemistry, biology and materials science, this book is a source of provocative thought and an arrow pointing to the central role of synthesis in the way chemistry impinges on scientific activity.
Content:
Front Matter....Pages i-xi
Asymmetric Synthesis : I - Fundamentals and Recent Advances II - Some Aspects of Asymmetric Catalysis with Transition - Metal Complexes....Pages 1-23
Addition of Enolates and Metalloalkyls to Imines. Stereospecific Synthesis of ?-Lactams, Amines, Aziridines and Aminols....Pages 25-60
Target-driven Organic Synthesis: Reflections on the Past, Prospects for the Future....Pages 61-90
Optically Active Transition Metal Compounds Containing Chiral Transition Metal Atoms....Pages 91-111
Biomimetic Chemistry....Pages 113-135
Design of Enzyme Inhibitors....Pages 137-173
Enantioselective Catalysis with Transition Metal Complexes....Pages 175-190
Directed Aromatic Metalation : A Continuing Education in Flatland Chemistry....Pages 191-221
As We Head into the 21st Century, Is there Still Value in Total Synthesis of Natural Products as a Research Endeavor?....Pages 223-243
Convergent Strategies for Synthetic Receptors....Pages 245-261
The Advancement of Radical-Based Synthetic Strategies: From Reagent Design to Polymer Modification....Pages 263-276
Templated Synthesis of Enzyme Mimics: How Far can We Go?....Pages 277-291
Towards a Chemical Etiology of the Natural Nucleic Acids’ Structure....Pages 293-340
Principles of Antibody Catalysis....Pages 341-359
New Homocalixarenes and Catenanes....Pages 361-379
Self-Assembly in Chemical Synthesis....Pages 381-401
Oligonucleotide-Directed Recognition of Double-Helical DNA....Pages 403-417
Can Enzyme Mimics Compete with Catalytic Antibodies?....Pages 419-428
Synthesis of Giant Modular Structures....Pages 429-452
Polymer Synthesis and Stereochemistry with Transition Metal Catalysts....Pages 453-473
Making Unnatural Products by Natural Means....Pages 475-510
Supramolecular Chemistry and Chemical Synthesis....Pages 511-524
Synthetic Approaches to Functional Polymers....Pages 525-548
Transduction of Molecular Interactions into Macroscopic Properties....Pages 549-563
Approaches to Synthesis Based on Non-Covalent Bonds....Pages 565-588
The Functionalization of Saturated Hydrocarbons by Gif Chemistry. Part 1. Use of Superoxide and of Hydrogen Peroxide. Part 2. Use of t-Butylhydroperoxide (TBHP)....Pages 589-599
Organic Synthesis and the Life Sciences....Pages 601-619
Back Matter....Pages 621-625
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