Ebook: Protein Structure — Function Relationship

Although many pursue understanding of the relationship between protein structure and function for the thrill of pure science, the pay-off in a much broader sense is the ability to manipulate the Earth's chemistry and biology to improve the quality of life for mankind. Immediately goals of this area of research include identification of the life-supporting functions of proteins, and the fundamental forces that facilitate these functions. Upon reaching these goals, we shall have the understanding to direct and the tools required to implement changes that will dramatically improve the quality of life. For example, under­ standing the chemical mechanism of diseases will facilitate development of new therapeutic drugs. Likewise, understanding of chemical mechanisms of plant growth will be used with biotechnology to improve food production under adverse climatic conditions. The challenge to understand details of protein structure/function relationships is enormous and requires an international effort for success. To direct the chemistry and biology of our environment in a positive sense will require efforts from bright, imaginative scientists located throughout the world. Although the emergence of FAX, e-mail, and the World Wide Web has revolutionized international communication, there remains a need for scientists located in distant parts of the world to occasionally meet face to face.

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''Useful and stimulating information for biochemists engaged in both fundamental and applied biochemical research.'' --- Nahrung, 42(2), 1998

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''Useful and stimulating information for biochemists engaged in both fundamental and applied biochemical research.'' --- Nahrung, 42(2), 1998
Content:
Front Matter....Pages i-xi
How is the Dioxygen-Iron Bond Manipulated by Transport and Catalytic Haem Proteins?....Pages 1-12
A New Flow Modulated Continuous Bioreactor Based on Inversed Capillary Membranes for Low Risk Gene Technology....Pages 13-16
Characterization and Substrate Specificities of Various Mouse Kallikreins....Pages 17-23
Natural Occurence of Enzymes Linked to Inorganic Supports....Pages 25-43
New Developments on Human Milk Protein Composition and Function....Pages 45-49
Structure-Function of Two Membrane Protein Systems Involved in Transfer of Electrical Charge....Pages 51-59
?,?-Crystallins....Pages 61-69
The Use of Metal Ions as Spectroscopic Probes in the Elucidation of pKa’s of Small Molecules....Pages 71-80
Trypsin Complexed with ?1-Proteinase Inhibitor Has an Increased Structural Flexibility....Pages 81-89
Structures and Functions of Leginsulin and Leginsulin-Binding Protein....Pages 91-96
From Structure to Therapy?....Pages 97-108
New Insights into the Molecular Structure of the Agonists Binding Site of Protein Kinase C by Pseudoreceptor Modeling....Pages 109-122
The Use of Synchrotron Radiation in Protein Crystallography....Pages 123-133
NMR Approaches to the Study of Structure-Function Relationships in Iron-Sulfur Proteins....Pages 135-146
Thermodynamic Views of Inhibition, Activation and Denaturation of Adenosine Deaminase by Ring Opened Nucleosides and Denaturants....Pages 147-156
Domain Motions in Protein Crystals....Pages 157-165
Interaction of Bovine Serum Albumin and Hexadecyl Pyridinium Bromide Study by Surfactant Selective Electrode and Spectrophotometry....Pages 167-174
Ciliate Telomere Proteins....Pages 175-182
Diverse Actions of Human Lipoproteins on Arachidonic Acid Metabolism....Pages 183-191
Mechanism of Gonadotrophin Releasing Hormone Receptor Mediated Regulation of G-Proteins in Clonal Pituitary Gonadotrophs....Pages 193-201
Structural Studies of Carcinoembryonic Antigen (CEA) and Anti-CEA Engineered Antibodies Using Mass Spectrometry....Pages 203-212
Serotoninergic Neurones in the Zona Incerta Exerts Inhibitory Control on Gonadotrophin Release via 5-HT2A/2C Receptors....Pages 213-221
Structure Elucidation of Human Lens Proteins by Mass Spectrometry....Pages 223-235
Isolation, Characterization and Amino Acid Sequence of the N-Terminal Functional Unit from the Rapana thomasiana grosse (Marine Snail, Gastropod) Hemocyanin....Pages 237-248
Potential Applications of Plant Glycohydrolases for Oligosaccharide Synthesis....Pages 249-257
Two-Dimensional Electrophoresis and Automated Microsequencing....Pages 259-265
Posters....Pages 267-293
Back Matter....Pages 295-298

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''Useful and stimulating information for biochemists engaged in both fundamental and applied biochemical research.'' --- Nahrung, 42(2), 1998
Content:
Front Matter....Pages i-xi
How is the Dioxygen-Iron Bond Manipulated by Transport and Catalytic Haem Proteins?....Pages 1-12
A New Flow Modulated Continuous Bioreactor Based on Inversed Capillary Membranes for Low Risk Gene Technology....Pages 13-16
Characterization and Substrate Specificities of Various Mouse Kallikreins....Pages 17-23
Natural Occurence of Enzymes Linked to Inorganic Supports....Pages 25-43
New Developments on Human Milk Protein Composition and Function....Pages 45-49
Structure-Function of Two Membrane Protein Systems Involved in Transfer of Electrical Charge....Pages 51-59
?,?-Crystallins....Pages 61-69
The Use of Metal Ions as Spectroscopic Probes in the Elucidation of pKa’s of Small Molecules....Pages 71-80
Trypsin Complexed with ?1-Proteinase Inhibitor Has an Increased Structural Flexibility....Pages 81-89
Structures and Functions of Leginsulin and Leginsulin-Binding Protein....Pages 91-96
From Structure to Therapy?....Pages 97-108
New Insights into the Molecular Structure of the Agonists Binding Site of Protein Kinase C by Pseudoreceptor Modeling....Pages 109-122
The Use of Synchrotron Radiation in Protein Crystallography....Pages 123-133
NMR Approaches to the Study of Structure-Function Relationships in Iron-Sulfur Proteins....Pages 135-146
Thermodynamic Views of Inhibition, Activation and Denaturation of Adenosine Deaminase by Ring Opened Nucleosides and Denaturants....Pages 147-156
Domain Motions in Protein Crystals....Pages 157-165
Interaction of Bovine Serum Albumin and Hexadecyl Pyridinium Bromide Study by Surfactant Selective Electrode and Spectrophotometry....Pages 167-174
Ciliate Telomere Proteins....Pages 175-182
Diverse Actions of Human Lipoproteins on Arachidonic Acid Metabolism....Pages 183-191
Mechanism of Gonadotrophin Releasing Hormone Receptor Mediated Regulation of G-Proteins in Clonal Pituitary Gonadotrophs....Pages 193-201
Structural Studies of Carcinoembryonic Antigen (CEA) and Anti-CEA Engineered Antibodies Using Mass Spectrometry....Pages 203-212
Serotoninergic Neurones in the Zona Incerta Exerts Inhibitory Control on Gonadotrophin Release via 5-HT2A/2C Receptors....Pages 213-221
Structure Elucidation of Human Lens Proteins by Mass Spectrometry....Pages 223-235
Isolation, Characterization and Amino Acid Sequence of the N-Terminal Functional Unit from the Rapana thomasiana grosse (Marine Snail, Gastropod) Hemocyanin....Pages 237-248
Potential Applications of Plant Glycohydrolases for Oligosaccharide Synthesis....Pages 249-257
Two-Dimensional Electrophoresis and Automated Microsequencing....Pages 259-265
Posters....Pages 267-293
Back Matter....Pages 295-298
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