Ebook: Eicosanoids: From Biotechnology to Therapeutic Applications

Leukotriene A₄ Hydrolase: A Key Enzyme in the Biosynthesis of Leukotriene B₄; A. Wetterholm, et al. Lipoxygenases of Mice and Men; C.D. Funk. The Physiological and Therapeutic Significance of Separate Pathways for Prostaglandin Synthesis; D.L. De Witt. Assessment of Pharmacological Inhibition of PGHsynthases in Man; P.Patrignani, et al. Metabolism of Eicosanoids in Mammalian Cells; R.C.Murphy. New Approach in Immunometric Assays; P. Pradelles, et al.Transcellular Biosynthesis of Archidonic Acid Metabolites: From inVitro Investigations to in Vivo Reality; J. Maclouf. Polymorphonuclearendothelial Cell Interactions and the Control of Coronary Vasculature; A. Sala. Plateletactivating Factor Regulates Events at the Vascular Wall; S.M. Prescott, et al. Studies of Isoprostane Biosynthesis in Man; G. Ciabattoni, et al.N3 Fatty Acids: Antithromboxane Activity: Effects on Redox Status of Blood Cells; M.Lagarde, et al. Receptors and Second Messengers for Cysleukotrienes; S. Nicosia, et al.Prostanoid Receptors: Classification, Characterization and Therapeutic Relevance; R.A. Coleman. Microvascular Actions and Interactions of Eicosanoids and Histamine in Inflammation; P. Hedqvist, et al. 4 additional articles. Index.

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Content:
Front Matter....Pages i-ix
Leukotriene A4 Hydrolase: A Key Enzyme in the Biosynthesis of Leukotriene B4 ....Pages 1-12
Lipoxygenases of Mice and Men....Pages 13-20
The Physiological and Therapeutic Significance of Separate Pathways for Prostaglandin Synthesis....Pages 21-36
Assessment of Pharmacological Inhibition of PGH-Synthases in Man....Pages 37-44
Metabolism of Eicosanoids in Mammalian Cells....Pages 45-59
New Approach in Immunometric Assays....Pages 61-75
Transcellular Biosynthesis of Arachidonic Acid Metabolites: From in Vitro Investigations to in Vivo Reality....Pages 77-88
Polymorphonuclear-Endothelial Cell Interactions and the Control of Coronary Vasculature....Pages 89-97
PGHS-2 Dependent Formation of 8-Epi PGF2? by Human Monocytes....Pages 99-103
Platelet-Activating Factor Regulates Events at the Vascular Wall....Pages 105-109
Studies of Isoprostane Biosynthesis in Man....Pages 111-115
N-3 Fatty Acids. Antithromboxane Activity. Effects on Redox Status of Blood Cells....Pages 117-125
Receptors and Second Messengers for Cys-Leukotrienes....Pages 127-136
Prostanoid Receptors....Pages 137-154
Microvascular Actions and Interactions of Eicosanoids and Histamine in Inflammation....Pages 155-163
Leukotriene Antagonists and Synthetase Inhibitors; Clinical Applications in the Treatment of Bronchial Asthma....Pages 165-182
PGI2 and Its Analogs: From Pharmacology to Therapeutic Applications....Pages 183-193
Leukotriene Synthesis (FLAP) Inhibition: Biochemistry and Pharmacology of Bay X 1005....Pages 195-204
Back Matter....Pages 205-208

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Content:
Front Matter....Pages i-ix
Leukotriene A4 Hydrolase: A Key Enzyme in the Biosynthesis of Leukotriene B4 ....Pages 1-12
Lipoxygenases of Mice and Men....Pages 13-20
The Physiological and Therapeutic Significance of Separate Pathways for Prostaglandin Synthesis....Pages 21-36
Assessment of Pharmacological Inhibition of PGH-Synthases in Man....Pages 37-44
Metabolism of Eicosanoids in Mammalian Cells....Pages 45-59
New Approach in Immunometric Assays....Pages 61-75
Transcellular Biosynthesis of Arachidonic Acid Metabolites: From in Vitro Investigations to in Vivo Reality....Pages 77-88
Polymorphonuclear-Endothelial Cell Interactions and the Control of Coronary Vasculature....Pages 89-97
PGHS-2 Dependent Formation of 8-Epi PGF2? by Human Monocytes....Pages 99-103
Platelet-Activating Factor Regulates Events at the Vascular Wall....Pages 105-109
Studies of Isoprostane Biosynthesis in Man....Pages 111-115
N-3 Fatty Acids. Antithromboxane Activity. Effects on Redox Status of Blood Cells....Pages 117-125
Receptors and Second Messengers for Cys-Leukotrienes....Pages 127-136
Prostanoid Receptors....Pages 137-154
Microvascular Actions and Interactions of Eicosanoids and Histamine in Inflammation....Pages 155-163
Leukotriene Antagonists and Synthetase Inhibitors; Clinical Applications in the Treatment of Bronchial Asthma....Pages 165-182
PGI2 and Its Analogs: From Pharmacology to Therapeutic Applications....Pages 183-193
Leukotriene Synthesis (FLAP) Inhibition: Biochemistry and Pharmacology of Bay X 1005....Pages 195-204
Back Matter....Pages 205-208
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