Ebook: Targeting of Drugs 5: Strategies for Oligonucleotide and Gene Delivery in Therapy

Gene Therapy for Inherited Genetic Disease; Possibilities and Problems; C. Coutelle. Gene Delivery and Therapy: The Case for Cystic Fibrosis; E.W.F.W. Alton. Immune Responses with Direct Gene Transfer: DNA Vaccines and Implications for Gene Therapy; H.L. Davis. Oligonucleotides: Molecular Versions for Optimal Use In Vivo; E.Saison-Behmoaras, et al. Retrovirus Vectors in Gene Therapy: Targeting to Specific Cells; A.J. Kingsman, et al. Adenovirus as Vectors for Gene Therapy; M.G. Lee. Receptor-mediated Gene Delivery with Synthetic Virus-Like Particles; E. Wagner, et al. Controllable Gene Therapy-Recent Advances in Non-Viral Gene Delivery; A. Rolland. Genetic Chemistry: Towards Non-Enzymatic Ligation. Sequence-Selective Recognition of DNA and Self-Assembling Systems for Gene Delivery; J.-P. Behr. Integrin-Mediated Gene Delivery; S.L. Hart, et al. Design, Synthesis and Cellular Delivery of Antibody Targeted, Radiolabelled Oligonucleotide Conjugates for Cancer Therapy; C.S.R. Gooden, A.A.Epenetos. 7 Additional Articles. Index.

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Gene Therapy for Inherited Genetic Disease; Possibilities and Problems; C. Coutelle. Gene Delivery and Therapy: The Case for Cystic Fibrosis; E.W.F.W. Alton. Immune Responses with Direct Gene Transfer: DNA Vaccines and Implications for Gene Therapy; H.L. Davis. Oligonucleotides: Molecular Versions for Optimal Use In Vivo; E.Saison-Behmoaras, et al. Retrovirus Vectors in Gene Therapy: Targeting to Specific Cells; A.J. Kingsman, et al. Adenovirus as Vectors for Gene Therapy; M.G. Lee. Receptor-mediated Gene Delivery with Synthetic Virus-Like Particles; E. Wagner, et al. Controllable Gene Therapy-Recent Advances in Non-Viral Gene Delivery; A. Rolland. Genetic Chemistry: Towards Non-Enzymatic Ligation. Sequence-Selective Recognition of DNA and Self-Assembling Systems for Gene Delivery; J.-P. Behr. Integrin-Mediated Gene Delivery; S.L. Hart, et al. Design, Synthesis and Cellular Delivery of Antibody Targeted, Radiolabelled Oligonucleotide Conjugates for Cancer Therapy; C.S.R. Gooden, A.A.Epenetos. 7 Additional Articles. Index.
Content:
Front Matter....Pages i-viii
Gene Therapy for Inherited Genetic Disease: Possibilities and Problems....Pages 1-13
Gene Delivery and Therapy: The Case for Cystic Fibrosis....Pages 15-19
Immune Responses with Direct Gene Transfer: DNA Vaccines and Implications for Gene Therapy....Pages 21-29
Oligonucleotides: Molecular Versions for Optimal use in Vivo....Pages 31-43
Retrovirus Vectors in Gene Therapy: Targeting to Specific Cells....Pages 45-51
Adenovirus as Vectors for Gene Therapy....Pages 53-65
Receptor-Mediated Gene Delivery with Synthetic Virus-Like Particles....Pages 67-77
Controllable Gene Therapy: Recent Advances in Non-Viral Gene Delivery....Pages 79-95
Genetic Chemistry: Towards Non-Enzymatic Ligation, Sequence-Selective Recognition of DNA, and Self-Assembling Systems for Gene Delivery....Pages 97-100
Integrin-Mediated Gene Delivery....Pages 101-106
Design, Synthesis, and Cellular Delivery of Antibody Targeted, Radiolabelled Oligonucleotide Conjugates for Cancer Therapy....Pages 107-114
Poly (L Lysine) Mediated Delivery of Nucleic Acids....Pages 115-123
Complement Activation by Polylysine-DNA Complexes....Pages 125-130
Nanoparticles as Carriers for Antisense Oligonucleotides....Pages 131-142
Efficient Incorporation of Plasmid DNA Within Liposomes of Varying Structural Characteristics: Liposomal DNA Integrity and Transfection Efficiency....Pages 143-150
pH Sensitive Liposomes as Efficient Carriers for Intracellular Delivery of Oligonucleotides....Pages 151-162
Liposomal Delivery of P-Ethoxy Antisense Oligodeoxynucleotides in Chronic Myelogenous Leukemia....Pages 163-168
Liposome-Mediated Delivery of Genes and Oligonucleotides for the Treatment of Brain Tumors....Pages 169-178
Enzyme Assisted Synthesis of Delivery Systems....Pages 179-191
Back Matter....Pages 193-206

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Gene Therapy for Inherited Genetic Disease; Possibilities and Problems; C. Coutelle. Gene Delivery and Therapy: The Case for Cystic Fibrosis; E.W.F.W. Alton. Immune Responses with Direct Gene Transfer: DNA Vaccines and Implications for Gene Therapy; H.L. Davis. Oligonucleotides: Molecular Versions for Optimal Use In Vivo; E.Saison-Behmoaras, et al. Retrovirus Vectors in Gene Therapy: Targeting to Specific Cells; A.J. Kingsman, et al. Adenovirus as Vectors for Gene Therapy; M.G. Lee. Receptor-mediated Gene Delivery with Synthetic Virus-Like Particles; E. Wagner, et al. Controllable Gene Therapy-Recent Advances in Non-Viral Gene Delivery; A. Rolland. Genetic Chemistry: Towards Non-Enzymatic Ligation. Sequence-Selective Recognition of DNA and Self-Assembling Systems for Gene Delivery; J.-P. Behr. Integrin-Mediated Gene Delivery; S.L. Hart, et al. Design, Synthesis and Cellular Delivery of Antibody Targeted, Radiolabelled Oligonucleotide Conjugates for Cancer Therapy; C.S.R. Gooden, A.A.Epenetos. 7 Additional Articles. Index.
Content:
Front Matter....Pages i-viii
Gene Therapy for Inherited Genetic Disease: Possibilities and Problems....Pages 1-13
Gene Delivery and Therapy: The Case for Cystic Fibrosis....Pages 15-19
Immune Responses with Direct Gene Transfer: DNA Vaccines and Implications for Gene Therapy....Pages 21-29
Oligonucleotides: Molecular Versions for Optimal use in Vivo....Pages 31-43
Retrovirus Vectors in Gene Therapy: Targeting to Specific Cells....Pages 45-51
Adenovirus as Vectors for Gene Therapy....Pages 53-65
Receptor-Mediated Gene Delivery with Synthetic Virus-Like Particles....Pages 67-77
Controllable Gene Therapy: Recent Advances in Non-Viral Gene Delivery....Pages 79-95
Genetic Chemistry: Towards Non-Enzymatic Ligation, Sequence-Selective Recognition of DNA, and Self-Assembling Systems for Gene Delivery....Pages 97-100
Integrin-Mediated Gene Delivery....Pages 101-106
Design, Synthesis, and Cellular Delivery of Antibody Targeted, Radiolabelled Oligonucleotide Conjugates for Cancer Therapy....Pages 107-114
Poly (L Lysine) Mediated Delivery of Nucleic Acids....Pages 115-123
Complement Activation by Polylysine-DNA Complexes....Pages 125-130
Nanoparticles as Carriers for Antisense Oligonucleotides....Pages 131-142
Efficient Incorporation of Plasmid DNA Within Liposomes of Varying Structural Characteristics: Liposomal DNA Integrity and Transfection Efficiency....Pages 143-150
pH Sensitive Liposomes as Efficient Carriers for Intracellular Delivery of Oligonucleotides....Pages 151-162
Liposomal Delivery of P-Ethoxy Antisense Oligodeoxynucleotides in Chronic Myelogenous Leukemia....Pages 163-168
Liposome-Mediated Delivery of Genes and Oligonucleotides for the Treatment of Brain Tumors....Pages 169-178
Enzyme Assisted Synthesis of Delivery Systems....Pages 179-191
Back Matter....Pages 193-206
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