Ebook: The Meaning of Nucleocytoplasmic Transport

The means by which proteins and RNAs are exchanged between cytoplasm and nucleus have interested cell biologists for many years, and the field has seen a number of exciting recent advances. Much has been learned about the intricate architecture of the nuclear pore-complex, the mechanisms by which transport substrates are sorted, and the supply of energy for exchange processes. This book attempts a general review of the growing body of knowledge. However, the authors challenge the presumptions implicit in some interpretations of the evidence, re-examining the concept of "transport" within cells, and suggesting that lessons learned from nucleocytoplasmic transport studies can elucidate wider aspects of cell biology.

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Content:
Front Matter....Pages i-viii
Perspectives in Transport....Pages 1-20
The Vagaries of Diffusion....Pages 21-52
Cellular Structures and Nucleocytoplasmic Transport....Pages 53-80
Events at the Pore-Complex....Pages 81-117
Events Involving the Nucleoskeleton and Cytoskeleton....Pages 119-152
Regulation and Pathologies of Nucleocytoplasmic Transport....Pages 153-179
Evaluation of a Model....Pages 181-197
Back Matter....Pages 199-200

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Content:
Front Matter....Pages i-viii
Perspectives in Transport....Pages 1-20
The Vagaries of Diffusion....Pages 21-52
Cellular Structures and Nucleocytoplasmic Transport....Pages 53-80
Events at the Pore-Complex....Pages 81-117
Events Involving the Nucleoskeleton and Cytoskeleton....Pages 119-152
Regulation and Pathologies of Nucleocytoplasmic Transport....Pages 153-179
Evaluation of a Model....Pages 181-197
Back Matter....Pages 199-200
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