Ebook: Dietary Fats, Lipids, Hormones, and Tumorigenesis: New Horizons in Basic Research

This book was inspired by a gatheringofscientists in Los Angeles in 1994 under the auspices of the UCLA Clinical Nutrition Research Unit which is funded by the National Cancer Institute to promote new research into nutrition and cancer prevention. This unit supports research integrating basic and metabolic/clinical investigations which examine observations from epidemiologic studies and their application to the prevention ofcommon forms ofcancer through nutritional intervention. There is a great deal ofinformation from epidemiologic, experimental and metabolic studies implicating elements ofthe diet as important in the development and progression of common forms ofcancer including breast cancer, colon cancer, prostate cancer, and uterine cancer. When these forms ofcancerareexaminedcarefully, it isclearthat they share anumber ofcommon etiologic factors related to dietary fat, lipids, and hormones. A human cancer is usually discovered at a point where it has formed a detectable mass. For many forms of cancer, this may require 10 to 15 years from the time when the cancer is first initiated. Nutritional efforts at prevention may delay the progression ofcancer to a detectable mass resulting in reduced incidence and may retard the clinical progression and metastatic spread ofcancer after its primary treatment.

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Overview of Fat and Calories in Tumorigenesis; D. Kritchevsky Interrelationships of High Fat Diets, Obesity, Hormones, and Cancer D.Heber Nutrition and Human Breast Cancer; J. Glaspy Stromal-Epithelial Cell Interactions in Breast Cancer; D. Heber, et al. 20-epi-vitamin D₃ Analogs: Potent Modulators of Proliferation and Differentiation of Breast Cancer Cell Lines in vitro; E. Elstner, etal. Novel Lipids and Cancer: Isoprenoids and Other Phytochemicals; C.E. Elson Metabolism of Exogenous and Endogenous Arachidonic Acid in Cancer; S.D. Phinney Stable Isotopes and Mass Isotopomer Study of Fatty Acid and Cholesterol Synthesis: A Review of the MIDA Approach; W.N.P. Lee Lipid Bio-markers of Adherence to Low Fat Diets; J. Ashley Choline: A Nutrient that Is Involved in the Regulation of Cell Proliferation, Cell Death, and Cell Transformation; S. Zeisel The Role of Folate, Choline, and Methionine in Carcinogenesis; S.M. Henning,M.E. Swendseid Dietary Fat and Colon Cancer; J.R. Hecht High Fat Diet, Lipid Peroxidation, and Pancreatic Cancer; J. Zhang, V.L.W. Go Nutritional Approaches to the Prevention of Prostate Cancer; I. Yip,et al. Index. o

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Overview of Fat and Calories in Tumorigenesis; D. Kritchevsky Interrelationships of High Fat Diets, Obesity, Hormones, and Cancer D.Heber Nutrition and Human Breast Cancer; J. Glaspy Stromal-Epithelial Cell Interactions in Breast Cancer; D. Heber, et al. 20-epi-vitamin D₃ Analogs: Potent Modulators of Proliferation and Differentiation of Breast Cancer Cell Lines in vitro; E. Elstner, etal. Novel Lipids and Cancer: Isoprenoids and Other Phytochemicals; C.E. Elson Metabolism of Exogenous and Endogenous Arachidonic Acid in Cancer; S.D. Phinney Stable Isotopes and Mass Isotopomer Study of Fatty Acid and Cholesterol Synthesis: A Review of the MIDA Approach; W.N.P. Lee Lipid Bio-markers of Adherence to Low Fat Diets; J. Ashley Choline: A Nutrient that Is Involved in the Regulation of Cell Proliferation, Cell Death, and Cell Transformation; S. Zeisel The Role of Folate, Choline, and Methionine in Carcinogenesis; S.M. Henning,M.E. Swendseid Dietary Fat and Colon Cancer; J.R. Hecht High Fat Diet, Lipid Peroxidation, and Pancreatic Cancer; J. Zhang, V.L.W. Go Nutritional Approaches to the Prevention of Prostate Cancer; I. Yip,et al. Index. o
Content:
Front Matter....Pages i-x
Overview of Fat and Calories in Tumorigenesis....Pages 1-12
Interrelationships of High Fat Diets, Obesity, Hormones, and Cancer....Pages 13-25
Nutritional, Hormonal, and Environmental Mechanisms in Breast Tumorigenesis....Pages 27-40
Stromal-Epithelial Cell Interactions in Breast Cancer....Pages 41-51
20-EPI-Vitamin D3 Analogs....Pages 53-70
Novel Lipids and Cancer....Pages 71-86
Metabolism of Exogenous and Endogenous Arachidonic Acid in Cancer....Pages 87-94
Stable Isotopes and Mass Isotopomer Study of Fatty Acid and Cholesterol Synthesis....Pages 95-114
Lipid Biomarkers of Adherence to Low Fat Diets....Pages 115-129
Choline....Pages 131-141
The Role of Folate, Choline, and Methionine in Carcinogenesis Induced by Methyl-Deficient Diets....Pages 143-155
Dietary Fat and Colon Cancer....Pages 157-163
High Fat Diet, Lipid Peroxidation, and Pancreatic Carcinogenesis....Pages 165-172
Nutritional Approaches to the Prevention of Prostate Cancer Progression....Pages 173-181
Back Matter....Pages 183-185

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Overview of Fat and Calories in Tumorigenesis; D. Kritchevsky Interrelationships of High Fat Diets, Obesity, Hormones, and Cancer D.Heber Nutrition and Human Breast Cancer; J. Glaspy Stromal-Epithelial Cell Interactions in Breast Cancer; D. Heber, et al. 20-epi-vitamin D₃ Analogs: Potent Modulators of Proliferation and Differentiation of Breast Cancer Cell Lines in vitro; E. Elstner, etal. Novel Lipids and Cancer: Isoprenoids and Other Phytochemicals; C.E. Elson Metabolism of Exogenous and Endogenous Arachidonic Acid in Cancer; S.D. Phinney Stable Isotopes and Mass Isotopomer Study of Fatty Acid and Cholesterol Synthesis: A Review of the MIDA Approach; W.N.P. Lee Lipid Bio-markers of Adherence to Low Fat Diets; J. Ashley Choline: A Nutrient that Is Involved in the Regulation of Cell Proliferation, Cell Death, and Cell Transformation; S. Zeisel The Role of Folate, Choline, and Methionine in Carcinogenesis; S.M. Henning,M.E. Swendseid Dietary Fat and Colon Cancer; J.R. Hecht High Fat Diet, Lipid Peroxidation, and Pancreatic Cancer; J. Zhang, V.L.W. Go Nutritional Approaches to the Prevention of Prostate Cancer; I. Yip,et al. Index. o
Content:
Front Matter....Pages i-x
Overview of Fat and Calories in Tumorigenesis....Pages 1-12
Interrelationships of High Fat Diets, Obesity, Hormones, and Cancer....Pages 13-25
Nutritional, Hormonal, and Environmental Mechanisms in Breast Tumorigenesis....Pages 27-40
Stromal-Epithelial Cell Interactions in Breast Cancer....Pages 41-51
20-EPI-Vitamin D3 Analogs....Pages 53-70
Novel Lipids and Cancer....Pages 71-86
Metabolism of Exogenous and Endogenous Arachidonic Acid in Cancer....Pages 87-94
Stable Isotopes and Mass Isotopomer Study of Fatty Acid and Cholesterol Synthesis....Pages 95-114
Lipid Biomarkers of Adherence to Low Fat Diets....Pages 115-129
Choline....Pages 131-141
The Role of Folate, Choline, and Methionine in Carcinogenesis Induced by Methyl-Deficient Diets....Pages 143-155
Dietary Fat and Colon Cancer....Pages 157-163
High Fat Diet, Lipid Peroxidation, and Pancreatic Carcinogenesis....Pages 165-172
Nutritional Approaches to the Prevention of Prostate Cancer Progression....Pages 173-181
Back Matter....Pages 183-185
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