Ebook: Calreticulin
Author: Marek Michalak Ph.D. (auth.)
- Tags: Cell Biology, Biochemistry general
- Series: Molecular Biology Intelligence Unit
- Year: 1996
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
- pdf
This book is about calreticulin, a multifunctional calcium binding protein first discovered over 20 years ago. The protein has been described in various locations: endoplasmic reticulum, nuclear envelope, cytoplasmic granules, nucleus, cell surface and even secreted into the blood stream. This volume outlines the newly discovered functions for calreticulin including its control of calcium homeostasis, modulation of steroid-sensitive gene expression, control of viral RNA replication, modulation of nuclear transport, role in T lymphocyte activation and cytotoxic killing, chaperone function, control of adhesion-dependent signaling via integrins, possible role in the biology of ticks, in the pathology of autoimmune diseases and in blood function.
Content:
Front Matter....Pages i-xiii
A Current History of Calreticulin....Pages 1-10
Basic Characteristics and Ion Binding to Calreticulin....Pages 11-30
The Intracellular Distribution and Expression of Calreticulin....Pages 31-41
The Roles of Calnexin and Calreticulin as Endoplasmic Reticulum Molecular Chaperones....Pages 43-57
Calreticulin and Ca2+ Storage....Pages 59-76
Calreticulin and the Modulation of Gene Expression....Pages 77-88
Role of Calreticulin in Rubella Virus Replication....Pages 89-115
Calreticulin and Autoimmunity....Pages 117-139
Calreticulin in T Lymphocytes....Pages 141-153
Calreticulin and Thrombosis....Pages 155-168
Calreticulin in Vector Arthropods—The Secreted Calreticulin....Pages 169-180
Protein Nuclear Import is Modulated by Calreticulin....Pages 181-200
Back Matter....Pages 201-213
Content:
Front Matter....Pages i-xiii
A Current History of Calreticulin....Pages 1-10
Basic Characteristics and Ion Binding to Calreticulin....Pages 11-30
The Intracellular Distribution and Expression of Calreticulin....Pages 31-41
The Roles of Calnexin and Calreticulin as Endoplasmic Reticulum Molecular Chaperones....Pages 43-57
Calreticulin and Ca2+ Storage....Pages 59-76
Calreticulin and the Modulation of Gene Expression....Pages 77-88
Role of Calreticulin in Rubella Virus Replication....Pages 89-115
Calreticulin and Autoimmunity....Pages 117-139
Calreticulin in T Lymphocytes....Pages 141-153
Calreticulin and Thrombosis....Pages 155-168
Calreticulin in Vector Arthropods—The Secreted Calreticulin....Pages 169-180
Protein Nuclear Import is Modulated by Calreticulin....Pages 181-200
Back Matter....Pages 201-213
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