Ebook: Post-transcriptional Control of Gene Expression

Many important cellular processes rely on posttranscriptional control of gene expression. This book describes the mechanisms of gene expression at this level that occur in the cytoplasm of prokaryotes and eukaryotes. Several introductory chapters discuss the general principles of translation and mRNA stability. The interactions of mature mRNA with the translational machinery, the components of mRNA degradation and antisense RNA are surveyed. Subsequent chapters discuss protein folding, transport, modification and degradation. The book is an invaluable source of information for both newcomers and those wishing an overview of the field.

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Many important cellular processes rely on posttranscriptional control of gene expression. This book describes the mechanisms of gene expression at this level that occur in the cytoplasm of prokaryotes and eukaryotes. Several introductory chapters discuss the general principles of translation and mRNA stability. The interactions of mature mRNA with the translational machinery, the components of mRNA degradation and antisense RNA are surveyed. Subsequent chapters discuss protein folding, transport, modification and degradation. The book is an invaluable source of information for both newcomers and those wishing an overview of the field.

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Many important cellular processes rely on posttranscriptional control of gene expression. This book describes the mechanisms of gene expression at this level that occur in the cytoplasm of prokaryotes and eukaryotes. Several introductory chapters discuss the general principles of translation and mRNA stability. The interactions of mature mRNA with the translational machinery, the components of mRNA degradation and antisense RNA are surveyed. Subsequent chapters discuss protein folding, transport, modification and degradation. The book is an invaluable source of information for both newcomers and those wishing an overview of the field.
Content:
Front Matter....Pages I-XVI
Regulation of Eukaryotic Gene Expression at the Level of mRNA Stability: Emergence of General Principles....Pages 1-7
Enzymes Involved in Control of mRNA Decay in E.Coli ....Pages 9-35
Mechanisms and Structural Determinants of mRNA Decay in Bacteria....Pages 37-43
Changes in the Length of Poly(A) Tails and their Effects on mRNA Translation and Turnover....Pages 45-55
Mechanism and Regulation of Translation Initiation in Prokaryotes*....Pages 57-72
Regulation of Peptide Chain Termination....Pages 73-81
Structure-Function Correlations In The Bacterial Ribosome....Pages 83-91
Initiation Factor-Dependent Extracts: A Tool To Study Translation Initiation In Eukaryotes....Pages 93-98
RNA - Protein Recognition and Basic Mechanisms of Translational Repression in Prokaryotes....Pages 99-107
Translational Control in Escherichia coli and Saccharomyces cerevisiae ....Pages 109-124
Translational Control in Eukaryotic Cells: Principles Learned from the IRE/IRF System....Pages 125-133
Frameshifting in Prokaryotes and Eukaryotes....Pages 135-151
The Control, Detection and Exploitation of Translational Errors....Pages 153-164
Isolation and Characterization of Eukaryotic Translation Initiation, Elongation and Termination Factors....Pages 165-176
The phosphorylation of eukaryotic initiation factor 2 and its role in the regulation of translation during viral infection....Pages 177-185
Selective Proteolysis By the Ubiquitin System....Pages 187-191
The Role of Molecular Chaperones Hsp70 And Hsp60 in Protein Folding....Pages 193-206
Components and Mechanisms Involved in Protein Translocation Across the Endoplasmic Reticulum Membrane....Pages 207-220
Export of Proteins from Bacteria and Translocation of Proteins Across the Endoplasmic Reticulum of Eukaryotic Cells; a Comparison....Pages 221-230
Antisense RNA....Pages 231-261
Back Matter....Pages 262-272

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Many important cellular processes rely on posttranscriptional control of gene expression. This book describes the mechanisms of gene expression at this level that occur in the cytoplasm of prokaryotes and eukaryotes. Several introductory chapters discuss the general principles of translation and mRNA stability. The interactions of mature mRNA with the translational machinery, the components of mRNA degradation and antisense RNA are surveyed. Subsequent chapters discuss protein folding, transport, modification and degradation. The book is an invaluable source of information for both newcomers and those wishing an overview of the field.
Content:
Front Matter....Pages I-XVI
Regulation of Eukaryotic Gene Expression at the Level of mRNA Stability: Emergence of General Principles....Pages 1-7
Enzymes Involved in Control of mRNA Decay in E.Coli ....Pages 9-35
Mechanisms and Structural Determinants of mRNA Decay in Bacteria....Pages 37-43
Changes in the Length of Poly(A) Tails and their Effects on mRNA Translation and Turnover....Pages 45-55
Mechanism and Regulation of Translation Initiation in Prokaryotes*....Pages 57-72
Regulation of Peptide Chain Termination....Pages 73-81
Structure-Function Correlations In The Bacterial Ribosome....Pages 83-91
Initiation Factor-Dependent Extracts: A Tool To Study Translation Initiation In Eukaryotes....Pages 93-98
RNA - Protein Recognition and Basic Mechanisms of Translational Repression in Prokaryotes....Pages 99-107
Translational Control in Escherichia coli and Saccharomyces cerevisiae ....Pages 109-124
Translational Control in Eukaryotic Cells: Principles Learned from the IRE/IRF System....Pages 125-133
Frameshifting in Prokaryotes and Eukaryotes....Pages 135-151
The Control, Detection and Exploitation of Translational Errors....Pages 153-164
Isolation and Characterization of Eukaryotic Translation Initiation, Elongation and Termination Factors....Pages 165-176
The phosphorylation of eukaryotic initiation factor 2 and its role in the regulation of translation during viral infection....Pages 177-185
Selective Proteolysis By the Ubiquitin System....Pages 187-191
The Role of Molecular Chaperones Hsp70 And Hsp60 in Protein Folding....Pages 193-206
Components and Mechanisms Involved in Protein Translocation Across the Endoplasmic Reticulum Membrane....Pages 207-220
Export of Proteins from Bacteria and Translocation of Proteins Across the Endoplasmic Reticulum of Eukaryotic Cells; a Comparison....Pages 221-230
Antisense RNA....Pages 231-261
Back Matter....Pages 262-272
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