Ebook: Intracellular Signal Transduction: The JAK-STAT Pathway
- Tags: Cell Biology, Biochemistry general, Cancer Research
- Series: Molecular Biology Intelligence Unit
- Year: 1996
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
- pdf
This book is the first one written about the JAK/STAT pathway. The JAK (Janus Kinase) Protein tyrosine kinases are novel phosphotransferases absolutely required for cellular signalling downstream of non-catalytic cytokine receptors (amongst others). These molecules are components in pathways utilising the STAT (Signal Transducers and Activators of Transcription) transcription factors. The basic components of the JAK/STAT pathway are covered in detail, and the centre piece of the book is a guided tour of the pathway itself. An interesting addition to the book is the chapter on the use of Drosophila melanogaster as a genetic system to probe the pathway at the whole organism level. The book is targeted to researchers who have an interest in intracellular signalling.
Content:
Front Matter....Pages i-vii
Intracellular Signal Transduction....Pages 1-22
The Cytokine Receptor Family....Pages 23-43
The JAK Family of Protein Tyrosine Kinases....Pages 45-61
Signal Transducers and Activators of Transcription: The STAT Proteins....Pages 63-77
STFs: STAT-Containing Transcription Factors....Pages 79-91
Somatic Cell Genetic Dissection of Interferon Signal Transduction Pathways....Pages 93-103
A Guided Tour Through The JAK-STAT Pathway....Pages 105-132
Hopscotch/Tumorous Lethal: A JAK Family Member from Drosophila Melanogaster ....Pages 133-152
Future Trends....Pages 153-167
Back Matter....Pages 169-209
Content:
Front Matter....Pages i-vii
Intracellular Signal Transduction....Pages 1-22
The Cytokine Receptor Family....Pages 23-43
The JAK Family of Protein Tyrosine Kinases....Pages 45-61
Signal Transducers and Activators of Transcription: The STAT Proteins....Pages 63-77
STFs: STAT-Containing Transcription Factors....Pages 79-91
Somatic Cell Genetic Dissection of Interferon Signal Transduction Pathways....Pages 93-103
A Guided Tour Through The JAK-STAT Pathway....Pages 105-132
Hopscotch/Tumorous Lethal: A JAK Family Member from Drosophila Melanogaster ....Pages 133-152
Future Trends....Pages 153-167
Back Matter....Pages 169-209
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