Ebook: Arachidonic Acid in Cell Signaling

This book is about the arachidonic acid cascade, its biochemistry, its pharmacology, and its roles in signal transduction. Arachidonic acid may serve as an intracellular second messenger in many cell types, as well as precursor for biologically active molecules such as the eicosanoids (a family of oxygenated metabolites that may act as second messengers or as local mediators), and anandamide (an endogenous cannabinoid substance). Dysfunctions in the arachidonic acid cascade underlie a number of serious pathological conditions, making these biochemical pathways the target for drugs of clinical value.

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Content:
Front Matter....Pages i-vii
The Arachidonic Acid Cascade....Pages 1-14
Biosynthesis, Storage and Mobilization of Arachidonic Acid....Pages 15-53
Before Metabolism: Arachidonate as an Intracellular Second Messenger....Pages 55-78
Arachidonate Metabolism....Pages 79-131
The Eicosanoids in Cellular Signaling....Pages 133-166
Arachidonate Derivatives as Endogenous Cannabinoid Substances....Pages 167-195
Back Matter....Pages 197-199

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Content:
Front Matter....Pages i-vii
The Arachidonic Acid Cascade....Pages 1-14
Biosynthesis, Storage and Mobilization of Arachidonic Acid....Pages 15-53
Before Metabolism: Arachidonate as an Intracellular Second Messenger....Pages 55-78
Arachidonate Metabolism....Pages 79-131
The Eicosanoids in Cellular Signaling....Pages 133-166
Arachidonate Derivatives as Endogenous Cannabinoid Substances....Pages 167-195
Back Matter....Pages 197-199
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