Ebook: Vaccines: New Generation Immunological Adjuvants

During the last decade or so vaccine development has been facilitated by rapid advances in molecular and cell biology. These have laid the foundations of a new generation of vaccines exemplified by subunit vaccines produced through gene cloning and by synthetic peptides mimicking small regions of proteins on the outer coat of viruses. Such peptide~ are capable of eliciting virus-neutralizing antibodies. Unfortunately, subunit and peptide vaccines are only weakly or non immunogenic in the absence of immunological adjuvants that are known to augment specific cell-mediated immune responses to the antigens and to promote the formation of protective antibodies. This book contains the proceedings of the 4th NATO Advanced Studies Institute (ASI) "Vaccines: New Generation Immunological Adjuvants" held at Cape Sounion Beach, Greece, during 24 June -5 . July 1994 and deals in depth with both theoretical and practical aspects of vaccinology. These include the role of antigen presenting cells in the induction of immune responses. immunopotentiation by a variety of new generation immunological adjuvants and vaccine carriers. and recent advances and perspectives in experimental vaccines as well as vaccinatioll with nucleic acids. We express our appreciation to Dr. K. Dalsgaard and Dr. J. L. Virelizier for their cooperatioll in planning the ASI and to Mrs. Concha Pening for her excellent production of the manuscripts. The ASI was held under the sponsorship of NATO Scientific Affairs Division and generously co-sponsored by SmithKline Beecham Pharmaceuticals (Philadelphia).

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Content:
Front Matter....Pages i-viii
Adjuvants for New and Improved Vaccines....Pages 1-14
Liposome Mediated Immunopotentiation and Immunomodulation....Pages 15-24
Quil A, Anti-Carbohydrate Antibody Specificity and Biological Function....Pages 25-33
Vaccine Adjuvants Based On Gamma Inulin....Pages 35-44
Interleukin-2 as a Co-Adjuvant for Liposomal Tetanus Toxoid....Pages 45-50
Design of Vaccines for the Induction of Antibody Responses in Th-Cell Deficient Individuals....Pages 51-64
Strategies for the Stimulation of Th Cell Subsets....Pages 65-83
Feline Immunodeficiency Virus as a Vaccine Model....Pages 85-95
Rational Design of Vaccine Molecules to Prevent Pertussis....Pages 97-102
Multicomponent Viral Vaccines and Their Use as Immunogen Delivery Systems....Pages 103-116
Vaccines Against HPV of the Uterine Cervix: Problems in Clinical Applicability....Pages 117-121
Local Chemotherapy of Lymph Node Metastases: Optimization of Targeting Accuracy....Pages 123-126
Synthetic Peptide Vaccines: Success at Last....Pages 127-133
Peptide Vaccines; New Approaches to Immunopotentiation....Pages 135-140
Genetic Restriction of Responses to Peptide Antigens....Pages 141-146
DNA-Based Immunization: Prospects For a Hepatitis B Vaccine....Pages 147-160
Characterization of Immune Responses Elicited by an Experimental Facilitated-DNA Vaccine for Human Immunodeficiency Virus Type-1 (HIV-1)....Pages 161-171
Recombinant Self-Replicating RNA Vaccines....Pages 173-180
Back Matter....Pages 181-192

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Content:
Front Matter....Pages i-viii
Adjuvants for New and Improved Vaccines....Pages 1-14
Liposome Mediated Immunopotentiation and Immunomodulation....Pages 15-24
Quil A, Anti-Carbohydrate Antibody Specificity and Biological Function....Pages 25-33
Vaccine Adjuvants Based On Gamma Inulin....Pages 35-44
Interleukin-2 as a Co-Adjuvant for Liposomal Tetanus Toxoid....Pages 45-50
Design of Vaccines for the Induction of Antibody Responses in Th-Cell Deficient Individuals....Pages 51-64
Strategies for the Stimulation of Th Cell Subsets....Pages 65-83
Feline Immunodeficiency Virus as a Vaccine Model....Pages 85-95
Rational Design of Vaccine Molecules to Prevent Pertussis....Pages 97-102
Multicomponent Viral Vaccines and Their Use as Immunogen Delivery Systems....Pages 103-116
Vaccines Against HPV of the Uterine Cervix: Problems in Clinical Applicability....Pages 117-121
Local Chemotherapy of Lymph Node Metastases: Optimization of Targeting Accuracy....Pages 123-126
Synthetic Peptide Vaccines: Success at Last....Pages 127-133
Peptide Vaccines; New Approaches to Immunopotentiation....Pages 135-140
Genetic Restriction of Responses to Peptide Antigens....Pages 141-146
DNA-Based Immunization: Prospects For a Hepatitis B Vaccine....Pages 147-160
Characterization of Immune Responses Elicited by an Experimental Facilitated-DNA Vaccine for Human Immunodeficiency Virus Type-1 (HIV-1)....Pages 161-171
Recombinant Self-Replicating RNA Vaccines....Pages 173-180
Back Matter....Pages 181-192
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