Ebook: GABA: Receptors, Transporters and Metabolism

Highlighting the current developments and future directions in GABA research, the ambitious aim of this topical volume is to cover GABA from the molecular mechanisms of its transmission to new targets for pharmaceutical research. Distinguished scientists at the forefront of GABA research were invited to contribute reviews on glutamate decarboxylase and autoimmunity, molecular structure and functional regulation of GABA transporters, transmitter release and GABA receptor regulation, GABA receptor subtypes and functional regulation, and GABA receptor ligands and their therapeutic application. Describing the latest advances in what has become a rapidly-evolving field, this volume will prove immensely valuable to neuroscientists, pharmacologists, biochemists, and physiologists working in the field of GABA research.

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Highlighting the current developments and future directions in GABA research, the ambitious aim of this topical volume is to cover GABA from the molecular mechanisms of its transmission to new targets for pharmaceutical research. Distinguished scientists at the forefront of GABA research were invited to contribute reviews on glutamate decarboxylase and autoimmunity, molecular structure and functional regulation of GABA transporters, transmitter release and GABA receptor regulation, GABA receptor subtypes and functional regulation, and GABA receptor ligands and their therapeutic application. Describing the latest advances in what has become a rapidly-evolving field, this volume will prove immensely valuable to neuroscientists, pharmacologists, biochemists, and physiologists working in the field of GABA research.

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Highlighting the current developments and future directions in GABA research, the ambitious aim of this topical volume is to cover GABA from the molecular mechanisms of its transmission to new targets for pharmaceutical research. Distinguished scientists at the forefront of GABA research were invited to contribute reviews on glutamate decarboxylase and autoimmunity, molecular structure and functional regulation of GABA transporters, transmitter release and GABA receptor regulation, GABA receptor subtypes and functional regulation, and GABA receptor ligands and their therapeutic application. Describing the latest advances in what has become a rapidly-evolving field, this volume will prove immensely valuable to neuroscientists, pharmacologists, biochemists, and physiologists working in the field of GABA research.
Content:
Front Matter....Pages I-X
Establishment of GABA as an Inhibitory Neurotransmitter at Crustacean Neuromuscular Junction and in the Mammalian Central Nervous System....Pages 1-6
Physiological Aspects of GAD-GABA System in the Pancreatic Islet....Pages 7-12
Membrane Associated L-Glutamate Decarboxylase and Insulin-Dependent Diabetes Mellitus (IDDM)....Pages 13-22
Glutamate Decarboxylase, GABA and Autoimmunity....Pages 23-30
Stiff-Man Syndrome and Glutamic Acid Decarboxylase: An Updated View....Pages 31-43
Anti-GAD Antibody in Various Neurological Diseases....Pages 45-52
GABA Transporters: Structure, Function and Mechanism....Pages 53-61
Heterogeneity of Brain GABA Transporters....Pages 63-72
Developmental Expression of the GABA Transporter GAT4....Pages 73-82
Functional Regulation of GABA Transporters by PKC and their Distinct Localization....Pages 83-93
GABAB Receptor Control of Transmitter Release in the Spinal Cord....Pages 95-102
Role of GABAA and GABAB Receptors in Ca++ Homeostasis and Transmitter Release in Cerebellar Granule Neurons....Pages 103-113
Potentiation by Protein Kinase C Activation of GABA Release from Xenopus Oocytes Injected with Rat Brain mRNA....Pages 115-121
The Molecular Biology of GABAA Receptors and Its Applications....Pages 123-127
Modelling Functional Domains of the GABAA Receptor Chloride Channel....Pages 129-143
Regulation of GABAA Receptors by Multiple Protein Kinases....Pages 145-155
Enhancement of GABA-Induced Current by 20-Hydroxy- Ecdysone in Cultured Cortical Neurons....Pages 157-171
Differential Sensitivity during Development of GABA-Mediated Synaptic Transmission to a Neuroactive Steroid in Rat Hippocampus and Cerebellum....Pages 173-184
Ontogenic Changes of GABAA Function of the Rat Meynert Neuron....Pages 185-194
Gabaergic System Modulates the Formation of LTP (Long-Term Potentiation) in the Superior Colliculus....Pages 195-200
GABA Receptor-Chloride Channel Complex as a Target Site of Alcohol....Pages 201-207
Functional Analysis on GABAB Receptor Using a Reconstituted System with Purified GABAB Receptor, Gi/Go Protein and Adenylyl Cyclase....Pages 209-220
Paradoxical Facilitation of the Voltage-Dependent Calcium Current Following Activation of GABAB Receptors....Pages 221-226
Stereospecific GABAB Receptor Antagonism....Pages 227-235
A Novel GABA Response Identified Optically in the Nucleus of the Tractus Solitarius of the Chick Embryo....Pages 237-242
A Novel Benzodiazepine Partial Inverse Agonist, S-8510, as a Cognitive Enhancer....Pages 243-253
Spatial Benzodiazepine Receptor Imaging in the Human Brain....Pages 255-258
Does the GABAA Receptor Have a Role to Play in Angelman Syndrome?....Pages 259-266
Modulators of Both GABAA Receptor and Cytosolic Ca2+ Level Related to a Novel Treatment for Epilepsy....Pages 267-274
Muscimol Induces State-Dependent Learning Whereas Baclofen Impairs Place Learning in Morris Water Maze Task in Rats....Pages 275-282
GABAB Receptor Antagonists: Potential Therapeutic Applications....Pages 283-291
Expected Therapeutic Use of GABA Agonists and Antagonists for Gut Motility Disorders....Pages 293-296
GABAB Antagonists Block ?-Butyrolactone-Induced Absence Seizures and Coordinated Induction of Transcription Factors in Mouse Brain....Pages 297-305
Pharmacological Studies on Generalized Absence Seizure Regulation in Genetic and Drug-Induced Models....Pages 307-312
Back Matter....Pages 313-320
....Pages 321-324