Ebook: Neurotransmitters in the Human Brain

The study of neurotransmitters in the human brain has expanded spectacularly in recent years with the application of techniques from immunology and molecular biology. These techniques are now being used successfully to help decipher the chemical architecture of the human nervous system. The results of these studies are of great importance for the understanding and treatment of neurological and psychiatric disorders such as Alzheimer's, Parkinson's and Huntington's diseases, as well as depression and schizophrenia. Professor Istvan Tork was a pioneer in the chemical anatomy of the brain and carried out important studies on the neuroanatomy and distribution of neuropeptides and monoarnines in the brain; some of his best known work dealt with the dual innervation of the cortex by neurons containing serotonin. Istvan Tork died on November 21, 1992, after a long struggle with a temporal lobe glioma, leaving a profound legacy of friendship and scholarly work 1. It was decided by the editors of this volume to commemorate his work and the mentors hip he gave to his many students by convening a symposium on neurotransmitters in the human brain. The symposium was held at the University of New South Wales on February 5, 1994, and was attended by over one hundred participants, including many of Professor Tork's colleagues and students. The papers from this symposium are presented in this volume to stand as a tribute to the breadth and quality of his work and to the energy and achievement of his students.

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Content:
Front Matter....Pages i-viii
Neurotransmitters as Tools in the Mapping of the Human Brain....Pages 1-24
Dopaminergic Amacrine Cells of the Mammalian Retina....Pages 25-33
Development of GABA-Immunoreactive Neurons in the Human Visual Cortex....Pages 35-40
Chemical Organization of the Human Cerebral Cortex....Pages 41-60
GABA Neurons in the Primate Visual Cortex....Pages 61-77
Excitatory Amino Acids and Neurotoxicity in the Human Neocortex....Pages 79-99
Distribution of Neuropeptides in the Human Lower Brainstem (Pons and Medulla Oblongata)....Pages 101-113
Cytoarchitecture and Chemistry of Midbrain Dopaminergic Cell Groups....Pages 115-127
Cytoarchitecture and Chemistry of the Human Ascending Cholinergic System....Pages 129-153
Ascending Noradrenergic and Serotonergic Systems in the Human Brainstem....Pages 155-171
Huntington’s Disease and Neural Transplantation: GABAA Receptor Changes in the Basal Ganglia in Huntington’s Disease in the Human Brain and in the Quinolinic Acid Lesioned Rat Model of the Disease Following Fetal Neuron Transplants....Pages 173-197
Neurotransmitter Changes in Alzheimer’s Disease....Pages 199-219
Non-Dopamine Receptor Changes in Midbrain Nuclei in Parkinson’s Disease....Pages 221-239
Back Matter....Pages 241-245

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Content:
Front Matter....Pages i-viii
Neurotransmitters as Tools in the Mapping of the Human Brain....Pages 1-24
Dopaminergic Amacrine Cells of the Mammalian Retina....Pages 25-33
Development of GABA-Immunoreactive Neurons in the Human Visual Cortex....Pages 35-40
Chemical Organization of the Human Cerebral Cortex....Pages 41-60
GABA Neurons in the Primate Visual Cortex....Pages 61-77
Excitatory Amino Acids and Neurotoxicity in the Human Neocortex....Pages 79-99
Distribution of Neuropeptides in the Human Lower Brainstem (Pons and Medulla Oblongata)....Pages 101-113
Cytoarchitecture and Chemistry of Midbrain Dopaminergic Cell Groups....Pages 115-127
Cytoarchitecture and Chemistry of the Human Ascending Cholinergic System....Pages 129-153
Ascending Noradrenergic and Serotonergic Systems in the Human Brainstem....Pages 155-171
Huntington’s Disease and Neural Transplantation: GABAA Receptor Changes in the Basal Ganglia in Huntington’s Disease in the Human Brain and in the Quinolinic Acid Lesioned Rat Model of the Disease Following Fetal Neuron Transplants....Pages 173-197
Neurotransmitter Changes in Alzheimer’s Disease....Pages 199-219
Non-Dopamine Receptor Changes in Midbrain Nuclei in Parkinson’s Disease....Pages 221-239
Back Matter....Pages 241-245
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