Ebook: Interleukin-10

The presented information reflects a state-of-the-art summary of the pleiotropic effects of IL-10 in vitro and in vivo and will contribute to our understanding of the role of ILj-10 in the immune system and its potential clinicial utility in the near future. The book contains chapters in which the in vitro biological effects of IL-10 on both mouse and human lymphoid and myeloid cells are reviewed. In addition, the role of IL-10 in transplantation, parasite infections, inflammation, infectious diseases and bone formation is described. The effects of IL-10 in vivo are presented, describing an IL-10 transgenic mouse model, the IL-10 "knock-out" mouse, and the capacity of IL-10 to prevent lethal toxic shock in mice.

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Content:
Front Matter....Pages ii-xvi
Molecular Biology of Interleukin-10 and its Receptor....Pages 1-9
Physicochemical and Structural Properties of Interleukin-10....Pages 11-18
IL-10 and Human T Cells....Pages 19-27
Interleukin-10 and B Lymphocytes....Pages 29-36
Regulation of Human Monocyte Functions by Interleukin-10....Pages 37-52
Interleukin-10: An Inhibitor of Macrophage-Dependent Stimulation of Th1 Cells....Pages 53-58
IL-10 and Bone Formation/Hematopoiesis....Pages 59-67
Regulatory Function of IL-10 in Experimental Parasitic Infections....Pages 69-77
IL-10 in Mycobacterial Infection....Pages 79-89
IL-10 In Human Leishmaniasis....Pages 91-100
IL-10 and HIV-1 Replication....Pages 101-112
Interleukin-10 and Transplantation Tolerance....Pages 113-120
Effects of IL-10 in Lipopolysaccharide- and Superantigen-Induced Lethal Shock In Vivo....Pages 121-126
Inhibition of Cell-Mediated Immune Responses In Vivo by Recombinant IL-10....Pages 127-133
IL-10 Transgenic Mice....Pages 135-139
Interleukin-10 Deficient Mice....Pages 141-148
A Phase I Study of Interleukin-10 in Healthy Humans: Safety and Effects on Cytokine Production....Pages 149-158
Back Matter....Pages 159-167

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Content:
Front Matter....Pages ii-xvi
Molecular Biology of Interleukin-10 and its Receptor....Pages 1-9
Physicochemical and Structural Properties of Interleukin-10....Pages 11-18
IL-10 and Human T Cells....Pages 19-27
Interleukin-10 and B Lymphocytes....Pages 29-36
Regulation of Human Monocyte Functions by Interleukin-10....Pages 37-52
Interleukin-10: An Inhibitor of Macrophage-Dependent Stimulation of Th1 Cells....Pages 53-58
IL-10 and Bone Formation/Hematopoiesis....Pages 59-67
Regulatory Function of IL-10 in Experimental Parasitic Infections....Pages 69-77
IL-10 in Mycobacterial Infection....Pages 79-89
IL-10 In Human Leishmaniasis....Pages 91-100
IL-10 and HIV-1 Replication....Pages 101-112
Interleukin-10 and Transplantation Tolerance....Pages 113-120
Effects of IL-10 in Lipopolysaccharide- and Superantigen-Induced Lethal Shock In Vivo....Pages 121-126
Inhibition of Cell-Mediated Immune Responses In Vivo by Recombinant IL-10....Pages 127-133
IL-10 Transgenic Mice....Pages 135-139
Interleukin-10 Deficient Mice....Pages 141-148
A Phase I Study of Interleukin-10 in Healthy Humans: Safety and Effects on Cytokine Production....Pages 149-158
Back Matter....Pages 159-167
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