Ebook: The Coronaviridae
- Tags: Medical Microbiology, Plant Sciences, Animal Anatomy / Morphology / Histology, Microbial Ecology
- Series: The Viruses
- Year: 1995
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
Coronaviruses were recognized as a group of enveloped, RNA viruses in 1968 and accepted by the International Committee on the Taxonomy of Viruses as a separate family, the Coronaviridae, in 1975. By 1978, it had become evident that the coronavirus genomic RNA was infectious (i. e. , positive strand), and by 1983, at least the framework of the coronavirus replication strategy had been per ceived. Subsequently, with the application of recombinant DNA techniques, there have been remarkable advances in our understanding of the molecular biology of coronaviruses, and a mass of structural data concerning coronavirus genomes, mRNAs, and pro teins now exists. More recently, attention has been focused on the role of essential and accessory gene products in the coronavirus replication cyde and a molecular analysis of the structure-function relation ships of coronavirus proteins. Nevertheless, there are still large gaps in our knowledge, for instance, in areas such as the genesis of coronavirus subgenomic mRNAs or the function of the coronavirus RNA-dependent RNA polymerase. The diseases caused by coronaviruses have been known for much longer than the agents themselves. Possibly the first coronavirus-related disease to be recorded was feline infectious peritonitis, as early as 1912. The diseases associ ated with infectious bronchitis virus, transmissible gastroenteritis virus, and murine hepatitis virus were all well known before 1950.
Content:
Front Matter....Pages i-xviii
The Coronaviridae ....Pages 1-10
Coronavirus Replication, Transcription, and RNA Recombination....Pages 11-31
Coronavirus Gene Expression....Pages 33-54
Coronavirus Receptors....Pages 55-71
The Coronavirus Surface Glycoprotein....Pages 73-113
The Coronavirus Membrane Glycoprotein....Pages 115-139
The Coronavirus Nucleocapsid Protein....Pages 141-163
The Coronavirus Hemagglutinin Esterase Glycoprotein....Pages 165-179
The Small-Membrane Protein....Pages 181-189
The Coronavirus Nonstructural Proteins....Pages 191-217
The Molecular Biology of Toroviruses....Pages 219-238
The Coronaviruslike Superfamily....Pages 239-255
Pathogenesis and Diseases of the Central Nervous System Caused by Murine Coronaviruses....Pages 257-292
Feline Infectious Peritonitis....Pages 293-315
Epidemiology of Infectious Bronchitis Virus....Pages 317-335
Molecular Basis of Transmissible Gastroenteritis Virus Epidemiology....Pages 337-376
Pathogenesis of the Porcine Coronaviruses....Pages 377-388
Human Coronavirus Infections....Pages 389-401
The Pathogenesis of Torovirus Infections in Animals and Humans....Pages 403-413
Back Matter....Pages 415-418
Content:
Front Matter....Pages i-xviii
The Coronaviridae ....Pages 1-10
Coronavirus Replication, Transcription, and RNA Recombination....Pages 11-31
Coronavirus Gene Expression....Pages 33-54
Coronavirus Receptors....Pages 55-71
The Coronavirus Surface Glycoprotein....Pages 73-113
The Coronavirus Membrane Glycoprotein....Pages 115-139
The Coronavirus Nucleocapsid Protein....Pages 141-163
The Coronavirus Hemagglutinin Esterase Glycoprotein....Pages 165-179
The Small-Membrane Protein....Pages 181-189
The Coronavirus Nonstructural Proteins....Pages 191-217
The Molecular Biology of Toroviruses....Pages 219-238
The Coronaviruslike Superfamily....Pages 239-255
Pathogenesis and Diseases of the Central Nervous System Caused by Murine Coronaviruses....Pages 257-292
Feline Infectious Peritonitis....Pages 293-315
Epidemiology of Infectious Bronchitis Virus....Pages 317-335
Molecular Basis of Transmissible Gastroenteritis Virus Epidemiology....Pages 337-376
Pathogenesis of the Porcine Coronaviruses....Pages 377-388
Human Coronavirus Infections....Pages 389-401
The Pathogenesis of Torovirus Infections in Animals and Humans....Pages 403-413
Back Matter....Pages 415-418
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