Ebook: Immunobiology of Proteins and Peptides VIII: Manipulation or Modulation of the Immune Response

This volume summarizes the proceedings of the Eighth International Symposium on the Immunobiology of Proteins and Peptides which was held on November 16-20 in Rio Rico, Arizona. The articles represent papers by invited speakers as well as papers selected by the Scientific Council, from among those submitted by the participants, on the basis of quality and timeliness. This symposium series was established in 1976 for the purpose of bringing together, once every two or three years, active investigators in the forefront of contemporary immunology, to present their findings, discuss their significance in the light of current concepts and identify important new directions of investigation. The founding of the symposium was stimulated by the achievement of major breakthroughs in the understanding of the immune recognition of proteins and peptides. We believed that these breakthroughs would lead to the creation of a new generation of peptide reagents, which could have enormous potential in biological, therapeutic, and basic applications. This anticipated explosion has since occurred and many applications ofthese peptides are now being realized. The eighth symposium focused on the manipulation or modulation of the immune response. This volume broadly covers the areas of adjuvants, cytokines, vaccines, and the use of intravenous immunoglobulins for disease management. There is a clear need to identify methods for improving vaccine efficacy and guiding the host to respond with a particular type of immune response.

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Silicone Gels as Adjuvants: Effects on Humoral and Cellmediated Immune Responses; J.O. Naim, C.J. van Oss The Effect of Molecular Weight and Gel Preparation on Humoral Adjuvancy of Silicone Oils and Silicone Gels; J.O. Naim, C.J. van Oss Glucans as Immunological Adjuvants; N.Mohagheghpour, et al. Copolymer Adjuvants; R.N. Brey Regulation of Il4 and Il5 Secretion by Histamine and PGE2; M.M. Khan Immunoglobulin Isotype Modulation after Administration of Il12; V. Van Cleave, et al. Substance P Mediated Stimulation of Cytokine Levels in Cultured Murine Bone Marrow Stromal Cells; J.M. Manske, et al. Malaria Transmissionblocking Immunity: Identification of Epitopes and Evaluation of Immunogenicity; N. Kumar, et al. Experimental Feline Lyme Borreliosis As a Model for Testing Borrelia burgdorferi Vaccines; M.D. Gibson, et al. Liposoma Vaccines; S. Green, et al. Protection Strategies against Botulinum Toxin; L. Middlebrook Collagen Arthritis in T Cell Receptor Congenic Mice: A Unique Approach to Study the Role of T Cell Receptor Genotypes in Autoimmune Arthritis; G.H.H. Nabozny,C.S. David The Blood-Brain Barrier in Virusinduced Demyelination; C.J.R. Welsh, et al. 14 additional articles. Index.

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Silicone Gels as Adjuvants: Effects on Humoral and Cellmediated Immune Responses; J.O. Naim, C.J. van Oss The Effect of Molecular Weight and Gel Preparation on Humoral Adjuvancy of Silicone Oils and Silicone Gels; J.O. Naim, C.J. van Oss Glucans as Immunological Adjuvants; N.Mohagheghpour, et al. Copolymer Adjuvants; R.N. Brey Regulation of Il4 and Il5 Secretion by Histamine and PGE2; M.M. Khan Immunoglobulin Isotype Modulation after Administration of Il12; V. Van Cleave, et al. Substance P Mediated Stimulation of Cytokine Levels in Cultured Murine Bone Marrow Stromal Cells; J.M. Manske, et al. Malaria Transmissionblocking Immunity: Identification of Epitopes and Evaluation of Immunogenicity; N. Kumar, et al. Experimental Feline Lyme Borreliosis As a Model for Testing Borrelia burgdorferi Vaccines; M.D. Gibson, et al. Liposoma Vaccines; S. Green, et al. Protection Strategies against Botulinum Toxin; L. Middlebrook Collagen Arthritis in T Cell Receptor Congenic Mice: A Unique Approach to Study the Role of T Cell Receptor Genotypes in Autoimmune Arthritis; G.H.H. Nabozny,C.S. David The Blood-Brain Barrier in Virusinduced Demyelination; C.J.R. Welsh, et al. 14 additional articles. Index.
Content:
Front Matter....Pages i-xi
Silicone Gels as Adjuvants....Pages 1-6
The Effect of Molecular Weight and Gel Preparation on Humoral Adjuvancy of Silicone Oils and Silicone Gels....Pages 7-12
Glucans as Immunological Adjuvants....Pages 13-22
Copolymer Adjuvants....Pages 23-34
Immunoglobulin Isotype Modulation after Administration of IL-12....Pages 35-42
Substance P Mediated Stimulation of Cytokine Levels in Cultured Murine Bone Marrow Stromal Cells....Pages 43-52
Malaria Transmission-Blocking Immunity....Pages 53-64
Experimental Feline Lyme Borreliosis as a Model for Testing Borrelia Burgdorferi Vaccines....Pages 65-72
Liposomal Vaccines....Pages 73-82
Protection Strategies Against Botulinum Toxin....Pages 83-92
Collagen Arthritis in T Cell Receptor Congenic Mice....Pages 93-98
The Blood-Brain Barrier in Virus-Induced Demyelination....Pages 99-104
Idiotype Manipulation in Disease Management....Pages 105-116
Intravenous Immunoglobins (IVIGS) to Prevent and Treat Infectious Diseases....Pages 117-122
Qualitative and Quantitative Immune Response to Bacterial Capsular Polysaccharides and Their Conjugates in Mouse and Man....Pages 123-130
Autoimmune Recognition of Acetylcholine Receptor and Manipulation of the Autoimmune Responses by Synthetic Peptides....Pages 131-139
Amelioration of Autoimmune Reactions by Antigen-Induced Apoptosis of T Cells....Pages 141-156
Band 3 and Its Peptides During Aging, Radiation Exposure, and Alzheimer’s Disease: Alterations and Self-Recognition....Pages 157-166
Establishment of a Mouse Model of Myasthenia Gravis which Mimics Human Myasthenia Gravis Pathogenesis for Immune Intervention....Pages 167-193
Analysis of MHC-Specific Peptide Motifs....Pages 195-199
Autoantibodies Against Peptide-Defined Epitopes of T-Cell Receptors in Retrovirally Infected Humans and Mice....Pages 201-210
Characterization of Autoantibodies Directed Against T Cell Receptors....Pages 211-222
Autoregulation of TCR V Region Epitopes in Autoimmune Disease....Pages 223-229
Influence of the Anterior Chamber of The Eye on T-Cell Production of Extracellular Antigen-Specific Proteins....Pages 231-236
The Development and Use of T Cell Receptor Peptide Vaccines....Pages 237-248
Evidence that Immunosuppression is an Intrinsic Property of the Alpha-Fetoprotein Molecule....Pages 249-254
Back Matter....Pages 255-269
....Pages 271-275