Ebook: Molecular and Cell Biology of Human Gene Therapeutics
- Tags: Animal Anatomy / Morphology / Histology, Human Genetics
- Series: Molecular and Cell Biology of Human Diseases Series 20
- Year: 1995
- Publisher: Springer Netherlands
- Edition: 1
- Language: English
- pdf
advanced metastatic disease of solid tumors, dictates that each tumor mass, indeed each individual metastasis, will have a unique antigen and cytokine environment and hence unique response to immune modu lation. A differential response to immunotherapy is thus inevitable. 4. Many of the human trials described are not randomized and report survival or response against historical controls. Most tumors described are immunogenic human tumors: renal cell cancer and melanoma are most common. In order to avoid the well-described inter-patient vari ation and rare incidence of spontaneous response among patient samples as well as selection bias and changes in practice over time, randomized trials are required. 5. Immunological treatment is unlike conventional chemotherapy in its endpoint. Most chemotherapeutic regimes require a complete response or a good partial response for cure or good palliation. There are now many cases where immunotherapy has provided long-term palliation without massive tumor reduction. Immunity may be stimulated to a degree which holds tumorigenicity in check and most importantly, pro vides good palliation for the patient in a manner that differs essentially from chemotherapy.
Content:
Front Matter....Pages i-xv
Retroviral vectors....Pages 1-19
Adenoviral vectors....Pages 20-32
Herpes simplex virus vectors....Pages 33-63
Liposome-mediated gene transfer....Pages 64-82
Intramuscular injection of plasmid DNA....Pages 83-103
Yeast artificial chromosome vectors....Pages 104-124
Gene transfer and cancer chemotherapy....Pages 125-139
Vaccine immunotherapy for cancer....Pages 140-156
Inherited immunodeficiencies....Pages 157-174
Anti-viral strategies....Pages 175-194
AIDS and HIV infection....Pages 195-236
Cystic fibrosis and lung diseases....Pages 237-251
Arthritis....Pages 252-260
Duchenne muscular dystrophy....Pages 261-280
Cardiovascular disease....Pages 281-300
Degenerative and inherited neurological disorders....Pages 301-349
Mucopolysaccharidosis....Pages 350-367
DNA-based immunization....Pages 368-387
Back Matter....Pages 388-403
Content:
Front Matter....Pages i-xv
Retroviral vectors....Pages 1-19
Adenoviral vectors....Pages 20-32
Herpes simplex virus vectors....Pages 33-63
Liposome-mediated gene transfer....Pages 64-82
Intramuscular injection of plasmid DNA....Pages 83-103
Yeast artificial chromosome vectors....Pages 104-124
Gene transfer and cancer chemotherapy....Pages 125-139
Vaccine immunotherapy for cancer....Pages 140-156
Inherited immunodeficiencies....Pages 157-174
Anti-viral strategies....Pages 175-194
AIDS and HIV infection....Pages 195-236
Cystic fibrosis and lung diseases....Pages 237-251
Arthritis....Pages 252-260
Duchenne muscular dystrophy....Pages 261-280
Cardiovascular disease....Pages 281-300
Degenerative and inherited neurological disorders....Pages 301-349
Mucopolysaccharidosis....Pages 350-367
DNA-based immunization....Pages 368-387
Back Matter....Pages 388-403
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