Ebook: Basic Mechanisms of Physiologic and Aberrant Lymphoproliferation in the Skin

This book is based upon a series of papers originally presented at a NATO Advanced Studies Workshop of the same title held at the study Center HI Cappuccini," a converted monastery in San Miniato, a small village located between Pisa and Florence, Italy, in October 1991. Authors were asked to submit their completed chapters by the following February; these were then scanned onto computer disks, edited and returned to the authors for final revision, and updating, with a final deadline of February 1993. The authors were encouraged to make whatever modifications they wanted, especially regarding updating their chapters, with an eye to making the final product both comprehensive and current. In this we succeeded beyond our expectations, with most chapters extensively altered and many completely re-written and significantly expanded. Thus, although the original meeting was held in 1991, the chapters in this volume may be regarded as current from at least February, 1993, with some of the final updated revisions received as late as July, 1993. This book, as agreed in our original contract, has been delivered to the publisher "camera-ready. " This means that all of the scanning, editing, proofing and typesetting were done here, by the office of the Department of Dermatology at the New Jersey Medical School. We essentially produced the book, which the publisher, for the most part, then photocopied. This has been an enormous burden, borne mainly by my colleague in this division, Robert A.

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Cell Biology: Gammadelta T Lymphocytes in Mice and Man: A Review; J.Borst, et al. Ontogeny: Features and Functions of Epidermal T Lymphocytes; G. Stingl, et al.Lymphocyte Homing: Cytokine Neuropeptide Interactions in the Skin; T.A. Luger, et al. Effect of UV Light on Cytokine Production by Epidermal Cells; T. Schwarz, et al.Viruses: A New Retrovirus from Cutaneous Tcell Lymphoma; V. Manzari,et al. Survey of Cutaneous Tcell Lymphomas for Human Tlymphotropic Virus Infection; M. D'Incan, et al.Histology: Inflammatory Precursors of Mycosis Fungoides; W.C. Lambert. The Histological Spectrum of Cutaneous Tcell Lymphoma; N. Smith.Genotyping: BCL2 Gene Rearrangement and Protein Expression in Primary Cutaneous Bcell Lymphomas; F. Pezzella, et al.Immunomodulation and Tumor Progression. 35 additional articles. Index.

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Cell Biology: Gammadelta T Lymphocytes in Mice and Man: A Review; J.Borst, et al. Ontogeny: Features and Functions of Epidermal T Lymphocytes; G. Stingl, et al.Lymphocyte Homing: Cytokine Neuropeptide Interactions in the Skin; T.A. Luger, et al. Effect of UV Light on Cytokine Production by Epidermal Cells; T. Schwarz, et al.Viruses: A New Retrovirus from Cutaneous Tcell Lymphoma; V. Manzari,et al. Survey of Cutaneous Tcell Lymphomas for Human Tlymphotropic Virus Infection; M. D'Incan, et al.Histology: Inflammatory Precursors of Mycosis Fungoides; W.C. Lambert. The Histological Spectrum of Cutaneous Tcell Lymphoma; N. Smith.Genotyping: BCL2 Gene Rearrangement and Protein Expression in Primary Cutaneous Bcell Lymphomas; F. Pezzella, et al.Immunomodulation and Tumor Progression. 35 additional articles. Index.
Content:
Front Matter....Pages i-xii
?? T Lymphocytes in Mice and Man: A Review....Pages 1-16
Ontogeny, Features and Functions of Epidermal T Lymphocytes....Pages 17-27
Activation of Reactive Versus Malignant T Cells in Cutaneous T Cell Lymphoma: Role of Abnormal Antigen Presenting Cells and T Cell Activating Molecules....Pages 29-38
Factors Involved in the Localization and Activation of Murine ?? Positive Dendritic Epidermal T Cells....Pages 39-55
Morpho-Antigenic Features of Dendritic Cells as a Clue to the Interpretation of Skin Immune System-Related Disorders....Pages 57-76
Cell Trafficking Networks in Cutaneous T Cell Lymphoma....Pages 77-93
Cytokine Neuropeptide Interactions in the Skin....Pages 95-102
Effect of UV Light on Cytokine Production by Epidermal Cells....Pages 103-112
Adhesion Molecules Involved in the Extravasation of Lymphocytes in Lymphoid Organs and Chronically Inflamed Tissues....Pages 113-140
Adhesion Receptors in Normal Skin and Cutaneous Malignant Lymphomas: Pathophysiological and Clinical Correlations....Pages 141-155
Integrins and Homing Receptors in Cutaneous Lymphomas....Pages 157-175
A New Retrovirus from Cutaneous T-Cell Lymphoma....Pages 177-183
Survey of Cutaneous T Cell Lymphomas for Human T-Lymphotropic Virus Infection....Pages 185-193
HTLV-1 Proviral Sequences in Cutaneous CD30-Positive T Large Cell Lymphomas....Pages 195-204
Inflammatory Precursors of Mycosis Fungoides....Pages 205-216
The Histological Spectrum of Cutaneous T-Cell Lymphoma....Pages 217-230
Cutaneous T-Cell Lymphoma: Clues to Diagnosis in Early Lesions....Pages 231-242
Morphologic and Prognostic Features of Advanced Mycosis Fungoides....Pages 243-254
Primary Cutaneous CD30 (KI-1) Positive Large Cell Lymphomas: Definition and Differential Diagnostic Aspects....Pages 255-263
Analysis of Clinical, Histopathologic and Immunopathologic Parameters in Erythrodermic Variants of Cutaneous T-Cell Lymphoma with Implications for Staging....Pages 265-273
A Scoring System Based on Differentially Weighted Criteria for Establishing a Standardized Threshold for the Diagnosis of Early Mycosis Fungoides....Pages 275-290
Cutaneous B-Cell Lymphoma: A Salt-Related Tumor?....Pages 291-299
Proliferation Activity in Skin Lesions of Mycosis Fungoides: Prognostic and Pathophysiologic Implications....Pages 301-315
Erythrodermic Actinic Reticuloid....Pages 317-324
Morphometric Study of Primary Cutaneous Germinal Center Cell Lymphomas....Pages 325-332
BCL-2 Gene Rearrangement and Protein Expression in Primary Cutaneous B Cell Lymphomas....Pages 333-342
Changing Concepts on Cutaneous Pseudo-B Cell Lymphomas and their Relationship to Cutaneous B Cell Lymphomas....Pages 343-353
Diagnostic and Prognostic Significance of Clonal T-Cell Receptor Gene Rearrangements in the Peripheral Blood of Patients with Cutaneous T-Cell Lymphoma....Pages 355-361
Analysis of T Cell-Receptor Gene Configurations in Mycosis Fungoides....Pages 363-368
The Pathogenesis of Lymphomatoid Papulosis....Pages 369-378
T Cell Receptor Variable Region Gene Expression in Cutaneous T-Cell Lymphoma....Pages 379-391
Sezary Syndrome is Characterized by Genotraumatic T Cells....Pages 393-399
Chromosome Abnormalities in Cutaneous B-Cell Lymphomas....Pages 401-418
Mechanism for Tumor Progression in Lymphomatoid Papulosis: Hypothesis Based on Studies of Tumor Cell Lines Clonally Derived from Lymphomatoid Papulosis....Pages 419-424
Shedding of Interleukin-2 Receptor in Cutaneous Lymphomas: An Effective Mechanism to Circumvent Immunosurveillance?....Pages 425-433
The Skin as a Target Organ During II-2 Administration....Pages 435-450
Specific Immune Response Against Melanoma: Analysis at a Clonal Level....Pages 451-458
Response of Early Stage Cutaneous T-Cell Lymphoma to Ultraviolet B Phototherapy....Pages 459-467
A Murine T-Cell Lymphoma Model Showing Protection Against Tumor Development and Treatment of Established Disease....Pages 469-481
Molecular Mechanisms Responsible for Repair of Adducts Induced in Human Cellular DNA by Puva....Pages 483-496
Interferon Modulates Lymphoproliferation in the Skin....Pages 497-533
Use of Recombinant Interferon-?-2A in the Treatment of Cutaneous Lymphomas of T- and B-Cell Lineage....Pages 535-544
Thymopentin in SEzary Syndrome: Clinical and Immunological Effects....Pages 545-551
What is Mycosis Fungoides? A Modest Proposal....Pages 553-563
Terms and Abbreviations Used in Studies of Cutaneous Lymphoproliferative Phenomena....Pages 565-578
Back Matter....Pages 579-583
....Pages 584-651