Ebook: Growth Hormone II: Basic and Clinical Aspects

This book is a compendium of proceedings from the Symposium on Growth Hormone II: Basic and Clinical Aspects. The intent of the sym­ posium was to review current aspects of the rapidly expanding science of growth hormone (GH) neuroendocrinology, especially those develop­ ments that occurred since our last meeting in 1985. The meeting was timely since there have been many new and exciting developments in basic research on the GH axis, and several new clinical applications for GH other than growth have been identified. For example, significant strides have been made into use of the bioengineered hormone as an anabolic in debilitated states and as an immunorestorative agent. Both these areas have received most attention as they relate to geriatric popu­ lations. Furthermore, recent focus on a novel family of GH secretagogues that complement the action of GHRH has shown that in animal models, these compounds have the potential to restore GH secretion in deficient or insufficient states, including growth retardation, obesity, and aging. Accordingly, these xenobiotics may have significant potential as drug products to stimulate physiological GH secretion and, thus, resist or reverse some of the maladaptive changes in form and function resulting from GH insufficiency. The importance of these agents as drug candidates is underscored by the diversity of molecules that have been studied by various pharmaceutical companies and the recent discovery that non­ peptide analogs with high oral bioavailability can be synthesized.

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This volume contains the proceedings of the Second International Symposium on Growth Hormone (GH): Basic and Clinical Aspects, held in December 1992 to review current aspects of the rapidly expanding science of GH neuroendocrinology. The authors first present a background of neuroendocrine regulatory processes incorporating the roles of GHRH and somatostatin (SRIF) as major controllers of GH secretion. The book then proceeds to discuss the most recent information on the cellular and molecular mechanisms by which these compounds regulate GH secretion non-growth functions of GH, with major focus on GH and immune function generalized effects of GH in the aged GH insufficiency structural and functional analyses of GH secretagogues and current clinical studies involving GH.

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This volume contains the proceedings of the Second International Symposium on Growth Hormone (GH): Basic and Clinical Aspects, held in December 1992 to review current aspects of the rapidly expanding science of GH neuroendocrinology. The authors first present a background of neuroendocrine regulatory processes incorporating the roles of GHRH and somatostatin (SRIF) as major controllers of GH secretion. The book then proceeds to discuss the most recent information on the cellular and molecular mechanisms by which these compounds regulate GH secretion non-growth functions of GH, with major focus on GH and immune function generalized effects of GH in the aged GH insufficiency structural and functional analyses of GH secretagogues and current clinical studies involving GH.
Content:
Front Matter....Pages i-xx
Front Matter....Pages 1-1
Pharmacology of GRF and Somatostatin: Positive and Negative Control of GH Release....Pages 3-16
Ionic Mechanisms Governing the Control of Growth Hormone Secretion by Somatostatin....Pages 17-32
Biochemical and Functional Properties of Somatostatin Receptors....Pages 33-46
Regulation of Growth Hormone Output: The GRF Signal....Pages 47-65
Regulation of Growth Hormone Secretion in Man....Pages 66-72
Mechanisms for Insulin-Like Growth Factor I Regulation of Growth Hormone Secretion....Pages 73-84
Front Matter....Pages 85-85
Role of Growth Hormone and Insulin-Like Growth Factor I in Immunoregulation....Pages 87-103
Production and Function of Growth Hormone in the Immune System....Pages 104-115
Immunomodulating Role of Growth Hormone....Pages 116-130
Front Matter....Pages 131-131
Further Observations on the Effects of Human Growth Hormone in Elderly Hyposomatomedinemic Men....Pages 133-149
Effects of Growth Hormone in Older People....Pages 150-154
Alteration of Growth Hormone Secretion in Aging: Peripheral Effects....Pages 155-166
Effects of Growth Hormone Releasing Peptides on Stimulated Growth Hormone Secretion in Old Rats....Pages 167-192
Changes in Growth Hormone Secretory Dynamics in Chronic Renal Failure and in Adaptation to Moderately High Altitude Living....Pages 193-199
Front Matter....Pages 201-201
Atypical Growth Hormone Releasing Peptides....Pages 203-222
Growth Hormone Releasing Hexapeptide: Basic Research and Clinical Application....Pages 223-230
Molecular Endocrinology of Human Growth Hormone....Pages 231-241
Growth Hormone Binding Protein: A Modulator of Growth Hormone Activity....Pages 242-255
Front Matter....Pages 257-257
Growth Hormone Treatment, Acromegaly, and Relationship to Cancer and Leukemia....Pages 259-268
Clinical Applications of Growth Hormone Treatment in Childhood....Pages 269-278
Front Matter....Pages 257-257
Medical and Scientific Aspects of Growth Hormone Receptor Deficiency (Laron Syndrome) in Ecuador....Pages 279-285
Spontaneous Growth Hormone Secretion in Children With Normal and Abnormal Growth....Pages 286-298
Front Matter....Pages 299-299
Expression of the Short Isoform of the Growth Hormone Receptor in Adipocytes....Pages 301-316
Effects of Porcine Somatotropin on Thymic Weight, Thymosin ?1, and Thymosin ?4 in Gilts and Barrows....Pages 317-327
Effects of an Acetylcholine Precursor on GH Secretion in Elderly Subjects....Pages 328-337
Even Short-Term hGH Treatment Induces Endocrine Changes in the Elderly....Pages 338-346
Dichotomic Role of Glucocorticoids in the Regulation of Growth Hormone Secretion In Vivo....Pages 347-358
Back Matter....Pages 359-379

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This volume contains the proceedings of the Second International Symposium on Growth Hormone (GH): Basic and Clinical Aspects, held in December 1992 to review current aspects of the rapidly expanding science of GH neuroendocrinology. The authors first present a background of neuroendocrine regulatory processes incorporating the roles of GHRH and somatostatin (SRIF) as major controllers of GH secretion. The book then proceeds to discuss the most recent information on the cellular and molecular mechanisms by which these compounds regulate GH secretion non-growth functions of GH, with major focus on GH and immune function generalized effects of GH in the aged GH insufficiency structural and functional analyses of GH secretagogues and current clinical studies involving GH.
Content:
Front Matter....Pages i-xx
Front Matter....Pages 1-1
Pharmacology of GRF and Somatostatin: Positive and Negative Control of GH Release....Pages 3-16
Ionic Mechanisms Governing the Control of Growth Hormone Secretion by Somatostatin....Pages 17-32
Biochemical and Functional Properties of Somatostatin Receptors....Pages 33-46
Regulation of Growth Hormone Output: The GRF Signal....Pages 47-65
Regulation of Growth Hormone Secretion in Man....Pages 66-72
Mechanisms for Insulin-Like Growth Factor I Regulation of Growth Hormone Secretion....Pages 73-84
Front Matter....Pages 85-85
Role of Growth Hormone and Insulin-Like Growth Factor I in Immunoregulation....Pages 87-103
Production and Function of Growth Hormone in the Immune System....Pages 104-115
Immunomodulating Role of Growth Hormone....Pages 116-130
Front Matter....Pages 131-131
Further Observations on the Effects of Human Growth Hormone in Elderly Hyposomatomedinemic Men....Pages 133-149
Effects of Growth Hormone in Older People....Pages 150-154
Alteration of Growth Hormone Secretion in Aging: Peripheral Effects....Pages 155-166
Effects of Growth Hormone Releasing Peptides on Stimulated Growth Hormone Secretion in Old Rats....Pages 167-192
Changes in Growth Hormone Secretory Dynamics in Chronic Renal Failure and in Adaptation to Moderately High Altitude Living....Pages 193-199
Front Matter....Pages 201-201
Atypical Growth Hormone Releasing Peptides....Pages 203-222
Growth Hormone Releasing Hexapeptide: Basic Research and Clinical Application....Pages 223-230
Molecular Endocrinology of Human Growth Hormone....Pages 231-241
Growth Hormone Binding Protein: A Modulator of Growth Hormone Activity....Pages 242-255
Front Matter....Pages 257-257
Growth Hormone Treatment, Acromegaly, and Relationship to Cancer and Leukemia....Pages 259-268
Clinical Applications of Growth Hormone Treatment in Childhood....Pages 269-278
Front Matter....Pages 257-257
Medical and Scientific Aspects of Growth Hormone Receptor Deficiency (Laron Syndrome) in Ecuador....Pages 279-285
Spontaneous Growth Hormone Secretion in Children With Normal and Abnormal Growth....Pages 286-298
Front Matter....Pages 299-299
Expression of the Short Isoform of the Growth Hormone Receptor in Adipocytes....Pages 301-316
Effects of Porcine Somatotropin on Thymic Weight, Thymosin ?1, and Thymosin ?4 in Gilts and Barrows....Pages 317-327
Effects of an Acetylcholine Precursor on GH Secretion in Elderly Subjects....Pages 328-337
Even Short-Term hGH Treatment Induces Endocrine Changes in the Elderly....Pages 338-346
Dichotomic Role of Glucocorticoids in the Regulation of Growth Hormone Secretion In Vivo....Pages 347-358
Back Matter....Pages 359-379
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