Ebook: Glyco-and Cellbiology: Biosynthesis, Transport, and Function of Glycoconjugates

Understanding the biological role of the diverse oligosaccharides of glycoproteins and glycolipids has been a major challenge in cell biology. Glycosylation is an essential step during molecular recognition and is involved in protein folding, sorting, targeting and intracellular translocation. Further, glycoproteins of the cell membrane play a major role in cell adhesion, hormone function, antibody action and signal mediation. Current knowledge of the molecular and cellular mechanisms involved in these processes is presented.

---

Understanding the biological role of the diverse oligosaccharides of glycoproteins and glycolipids has been a major challenge in cell biology. Glycosylation is an essential step during molecular recognition and is involved in protein folding, sorting, targeting and intracellular translocation. Further, glycoproteins of the cell membrane play a major role in cell adhesion, hormone function, antibody action and signal mediation. Current knowledge of the molecular and cellular mechanisms involved in these processes is presented.

---

Understanding the biological role of the diverse oligosaccharides of glycoproteins and glycolipids has been a major challenge in cell biology. Glycosylation is an essential step during molecular recognition and is involved in protein folding, sorting, targeting and intracellular translocation. Further, glycoproteins of the cell membrane play a major role in cell adhesion, hormone function, antibody action and signal mediation. Current knowledge of the molecular and cellular mechanisms involved in these processes is presented.
Content:
Front Matter....Pages I-VII
Components and Mechanisms Involved in Protein Translocation Through the ER Membrane....Pages 1-8
Protein Sorting Signals for Maintaining Transmembrane Proteins in the Endoplasmatic Reticulum....Pages 9-21
Protein Retention in the Golgi Stack....Pages 23-32
Signal-Mediated Targeting of Lysosomal Membrane Glycoproteins....Pages 33-44
VIP21, Caveolae and Sorting in the Trans-Golgi Network of Epithelial Cells....Pages 45-51
Biogenesis of Neurosecretory Vesicles....Pages 53-59
Lipid Transport from the Golgi Complex to the Plasma Membrane of Epithelial Cells....Pages 61-68
Topology and Regulation of Ganglioside Metabolism — Function and Pathobiochemistry of Sphingolipid Activator Proteins....Pages 69-79
Why Does Baker’s Yeast Glycosylate Proteins?....Pages 81-89
Glycosylation of Nuclear and Cytoplasmic Proteins Is as Abundant and as Dynamic as Phosphorylation....Pages 91-103
Novel N-Glycosylation in Eukaryotes: Laminin Contains the Linkage Unit ?-Glucosylasparagine....Pages 105-118
Reprocessing of Membrane Glycoproteins....Pages 119-130
Mutational Analysis of Carbohydrate and Phospholipid Modifications of a Cell Adhesion Protein....Pages 131-144
Towards Understanding Roles of Oligosaccharides as Recognition Structures....Pages 145-160
The Biologic Significance of Glycoprotein Hormone Oligosaccharides....Pages 161-169
Biosynthesis of Antibodies and Molecular Chaperones....Pages 171-184
Function of Molecular Chaperones in Protein Folding....Pages 185-194

---

Understanding the biological role of the diverse oligosaccharides of glycoproteins and glycolipids has been a major challenge in cell biology. Glycosylation is an essential step during molecular recognition and is involved in protein folding, sorting, targeting and intracellular translocation. Further, glycoproteins of the cell membrane play a major role in cell adhesion, hormone function, antibody action and signal mediation. Current knowledge of the molecular and cellular mechanisms involved in these processes is presented.
Content:
Front Matter....Pages I-VII
Components and Mechanisms Involved in Protein Translocation Through the ER Membrane....Pages 1-8
Protein Sorting Signals for Maintaining Transmembrane Proteins in the Endoplasmatic Reticulum....Pages 9-21
Protein Retention in the Golgi Stack....Pages 23-32
Signal-Mediated Targeting of Lysosomal Membrane Glycoproteins....Pages 33-44
VIP21, Caveolae and Sorting in the Trans-Golgi Network of Epithelial Cells....Pages 45-51
Biogenesis of Neurosecretory Vesicles....Pages 53-59
Lipid Transport from the Golgi Complex to the Plasma Membrane of Epithelial Cells....Pages 61-68
Topology and Regulation of Ganglioside Metabolism — Function and Pathobiochemistry of Sphingolipid Activator Proteins....Pages 69-79
Why Does Baker’s Yeast Glycosylate Proteins?....Pages 81-89
Glycosylation of Nuclear and Cytoplasmic Proteins Is as Abundant and as Dynamic as Phosphorylation....Pages 91-103
Novel N-Glycosylation in Eukaryotes: Laminin Contains the Linkage Unit ?-Glucosylasparagine....Pages 105-118
Reprocessing of Membrane Glycoproteins....Pages 119-130
Mutational Analysis of Carbohydrate and Phospholipid Modifications of a Cell Adhesion Protein....Pages 131-144
Towards Understanding Roles of Oligosaccharides as Recognition Structures....Pages 145-160
The Biologic Significance of Glycoprotein Hormone Oligosaccharides....Pages 161-169
Biosynthesis of Antibodies and Molecular Chaperones....Pages 171-184
Function of Molecular Chaperones in Protein Folding....Pages 185-194
....