Ebook: Angiogenesis: Molecular Biology, Clinical Aspects

Angiogenesis is a multistep process, which involves activation, proliferation and directed migration of endothelial cells to form new capillaries from existing vessels. Under physiological conditions, in the adult organisms angiogenesis is extremely slow, yet it can be activated for a limited time only in situations such as ovulation or wound healing. In a number of disease states, however, there is a derangement of angiogenesis, which can contribute to the pathology of these conditions. Hence, understanding the molecular biology of endothelial cell activation and differentiation and the mechanisms involved in the regulation of angiogenesis, could explain the derangement in disease states and also provide the basis for developing promoters or suppressors of angiogenesis for clinical applications. This book contains the proceedings of the NATO Advanced Study Institute on "Angiogenesis: Molecular Biology, Oinical Aspects" held in Rhodes, Greece, from June 16-27, 1993. This meeting was a comprehensive review of the various aspects of angiogenesis such as embryonic development, endothelial cell heterogeneity and tissue specificity, molecular biology of endothelial cell, mechanisms for the regulation of angiogenesis, disease states in which angiogenesis is involved and potential application of promoters or suppressors of angiogenesis. The presentations and discussions of the meeting provided an opportunity for investigators from many different areas of basic science and medicine to exchange information, evaluate the present status and provide future research directions in the field of angiogenesis.

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Content:
Front Matter....Pages i-x
Embryology of the Endothelial Network: Is There an Hemangioblastic Anlage ?....Pages 1-8
Cellular and Molecular Biology of Endothelial Cell Differentiation during Embryonic Development....Pages 9-14
Endothelial Cell Heterogeneity and Organ — Specificity....Pages 15-28
Inhibitors of Neovascularization: Critical Mediators in the Coordinate Regulation of Angiogenesis....Pages 29-37
Human Basic Fibroblast Growth Factor: Structure-Function Relationship of an Angiogenic Molecule....Pages 39-50
Angiogenesis Models Identify Factors Which Regulate Endothelial Cell Differentiation....Pages 51-60
EMA-1, a Novel Endothelial Cell Surface Molecule That is Preferentially Expressed by Migrating Endothelial Cells....Pages 61-65
Early Response Genes in Endothelial Cells....Pages 67-72
P1GF: Placenta Derived Growth Factor....Pages 73-80
Expression of the M-Subunit of Laminin Correlates with Increased Cell Adhesion and Metastatic Propensity....Pages 81-89
The Proliferative Effect of Substance P on Capillary Endothelial Cells is Mediated by Nitric Oxide....Pages 91-96
Reactivation of Metalloproteinase-Inhibitor Complex by a Low Molecular Mass Angiogenic Factor....Pages 97-101
Interactions between Oxidized Lipoprotein (a) [Lp(a)], Monocytes and Endothelial Cells....Pages 103-109
Altered Proliferation of Retinal Microvascular Cells in Response to Non-Enzymatic Glycosylated Matrix Proteins....Pages 111-118
A Novel Laminin Domain Involved in Adhesion of Endothelial Cells....Pages 119-123
Regulation of Angiogenesis: The Role of Protein Kinase, Nitric Oxide, Thrombin and Basement Membrane Synthesis....Pages 125-134
Basement Membrane Laminin-Derived Peptide Sikvav Promotes Angiogenesis and Tumor Growth....Pages 135-141
Release of Gangliosides in the Microenvironment and Angiogenic Response in Vivo....Pages 143-147
Angiogenesis in Vitro: Cytokine Interactions and Balanced Extracellular Proteolysis....Pages 149-170
Endothelial Plasminogen Activators and Matrix Metalloproteinases in Fibrinolysis and Local Proteolysis....Pages 171-181
Tumor Antiangiogenesis: Which Way?....Pages 183-191
Therapeutic Angiogenesis in Surgery and Oncology....Pages 193-207
Endothelial Cell Stimulating Angiogenesis Factor in Relation to Disease Processes....Pages 209-217
Hyaluronan and Angiogenesis: Molecular Mechanisms and Clinical Applications....Pages 219-231
Chronic Cellular Injury and Human Proliferative Disorders....Pages 233-238
Cellular and Molecular Mechanisms of Angiogenesis in the Brain....Pages 239-244
Angiogenesis and Fibrin Degradation in Human Breast Cancer....Pages 245-252
Thrombin-Mediated Events Implicated in Post-Thrombotic Recovery....Pages 253-263
Anti-Tumor Effects of GBS Toxin are Caused by Induction of a Targeted Inflammatory Reaction....Pages 265-269
Biological Data and Docking Experiments of bFGF-Sulfonated Distamycin a Derivative Complex....Pages 271-276
Clinical Ocular Angiogenesis....Pages 277-282
In Vivo Assays for Angiogenesis....Pages 283-289
Micro Vascular Morphometry....Pages 291-305
The Corneal Model for the Study of Angiogenesis....Pages 307-313
Factitious Angiogenesis: Not so Factitious Anymore? The Role of Angiogenic Processes in the Endothelialization of Artificial Cardiovascular Prostheses....Pages 315-320
Some Problems of Trial Design for Anti-Angiogenic Agents in Cancer Therapy....Pages 321-331
Back Matter....Pages 333-358
....Pages 360-372