Ebook: Membrane Protein Structure: Experimental Approaches

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Content:
Front Matter....Pages i-x
Front Matter....Pages 1-1
Membrane Protein Structure and Stability: Implications of the First Crystallographic Analyses....Pages 3-26
Decoding the Signals of Membrane Protein Sequences....Pages 27-40
Folding and Assembly of Integral Membrane Proteins: An Introduction....Pages 41-96
Hydropathy Plots and the Prediction of Membrane Protein Topology....Pages 97-124
Front Matter....Pages 125-126
Experimental Determination of the Topography of Membrane Proteins: Lessons from the Nicotinic Acetylcholine Receptor, a Multisubunit Polytopic Protein....Pages 127-143
Use of Gene Fusions to Determine Membrane Protein Topology....Pages 144-163
Structure of F0F1ATPases Determined by Direct and Indirect Methods....Pages 164-177
Front Matter....Pages 179-180
Experimental Determination of Membrane Protein Secondary Structure Using Vibrational and CD Spectroscopies....Pages 181-205
High-Resolution Electron Crystallography of Membrane Proteins....Pages 206-223
Site-Directed Spin Labeling of Membrane Proteins....Pages 224-248
Nuclear Magnetic Resonance Approaches to Membrane Protein Structure....Pages 249-267
Structure of Integral Membrane Proteins within Membranes via X-Ray and Neutron Diffraction: From Oriented Multilayers to a Single Monolayer....Pages 268-280
Front Matter....Pages 281-281
Physical Studies of Peptide—Bilayer Interactions....Pages 283-313
Membrane Protein Structure: Lessons from Gramicidin....Pages 314-334
Use of Synthetic Peptides for the Study of Membrane Protein Structure....Pages 335-354
Diffraction Studies of Model and Natural Helical Peptides....Pages 355-380
Back Matter....Pages 381-395

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Content:
Front Matter....Pages i-x
Front Matter....Pages 1-1
Membrane Protein Structure and Stability: Implications of the First Crystallographic Analyses....Pages 3-26
Decoding the Signals of Membrane Protein Sequences....Pages 27-40
Folding and Assembly of Integral Membrane Proteins: An Introduction....Pages 41-96
Hydropathy Plots and the Prediction of Membrane Protein Topology....Pages 97-124
Front Matter....Pages 125-126
Experimental Determination of the Topography of Membrane Proteins: Lessons from the Nicotinic Acetylcholine Receptor, a Multisubunit Polytopic Protein....Pages 127-143
Use of Gene Fusions to Determine Membrane Protein Topology....Pages 144-163
Structure of F0F1ATPases Determined by Direct and Indirect Methods....Pages 164-177
Front Matter....Pages 179-180
Experimental Determination of Membrane Protein Secondary Structure Using Vibrational and CD Spectroscopies....Pages 181-205
High-Resolution Electron Crystallography of Membrane Proteins....Pages 206-223
Site-Directed Spin Labeling of Membrane Proteins....Pages 224-248
Nuclear Magnetic Resonance Approaches to Membrane Protein Structure....Pages 249-267
Structure of Integral Membrane Proteins within Membranes via X-Ray and Neutron Diffraction: From Oriented Multilayers to a Single Monolayer....Pages 268-280
Front Matter....Pages 281-281
Physical Studies of Peptide—Bilayer Interactions....Pages 283-313
Membrane Protein Structure: Lessons from Gramicidin....Pages 314-334
Use of Synthetic Peptides for the Study of Membrane Protein Structure....Pages 335-354
Diffraction Studies of Model and Natural Helical Peptides....Pages 355-380
Back Matter....Pages 381-395
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