Ebook: Multiple Drug Resistance in Cancer: Cellular, Molecular and Clinical Approaches

This book is an up-to-date review of current knowledge in the field of multiple drug resistance in human cancer. The literature up to the middle of 1993 is surveyed in specialist chapters written by different experts. Topics covered include the molecular genetics, cytogenetics and biochemistry of the mdr genes and P-glycoprotein; alternative transport proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione- S-transferases in MDR; cellular models for MDR in solid tumours and haemopoietic tumours; immunochemical and molecular biological techniques for detection of MDR-related gene expression; and clinical and pharmacological strategies to circumvent resistance. The book brings together a new combination of approaches to this serious clinical problem.

---

This book is an up-to-date review of current knowledge in the field of multiple drug resistance in human cancer. The literature up to the middle of 1993 is surveyed in specialist chapters written by different experts. Topics covered include the molecular genetics, cytogenetics and biochemistry of the mdr genes and P-glycoprotein; alternative transport proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione- S-transferases in MDR; cellular models for MDR in solid tumours and haemopoietic tumours; immunochemical and molecular biological techniques for detection of MDR-related gene expression; and clinical and pharmacological strategies to circumvent resistance. The book brings together a new combination of approaches to this serious clinical problem.

---

This book is an up-to-date review of current knowledge in the field of multiple drug resistance in human cancer. The literature up to the middle of 1993 is surveyed in specialist chapters written by different experts. Topics covered include the molecular genetics, cytogenetics and biochemistry of the mdr genes and P-glycoprotein; alternative transport proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione- S-transferases in MDR; cellular models for MDR in solid tumours and haemopoietic tumours; immunochemical and molecular biological techniques for detection of MDR-related gene expression; and clinical and pharmacological strategies to circumvent resistance. The book brings together a new combination of approaches to this serious clinical problem.

Content:
Front Matter....Pages i-viii
P-glycoprotein structure and evolutionary homologies....Pages 1-32
Molecular analysis of the multidrug transporter....Pages 33-62
Molecular cytogenetics of multiple drug resistance....Pages 63-89
Antibodies in the study of multiple drug resistance....Pages 91-107
Non-P-glycoprotein multidrug resistance in cell lines which are defective in the cellular accumulation of drug....Pages 109-125
Topoisomerase I in multiple drug resistance....Pages 127-135
Topoisomerase II in multiple drug resistance....Pages 137-154
Glutathione-related enzymes, glutathione and multidrug resistance....Pages 155-170
Pharmacologic circumvention of multidrug resistance....Pages 171-212
Multidrug resistance (MDR) genes in haematological malignancies....Pages 213-230
Human cell lines as models for multidrug resistance in solid tumours....Pages 231-256
Studies on low-level MDR cells....Pages 257-264
Differing patterns of cross-resistance resulting from exposures to specific antitumour drugs or to radiation in vitro ....Pages 265-288
The use of reverse transcriptase-polymerase chain reaction (RT-PCR) to investigate specific gene expression in multidrug-resistant cells....Pages 289-314
Mathematical models for multidrug resistance and its reversal....Pages 315-324
The biology of radioresistance: similarities, differences and interactions with drug resistance....Pages 325-345
Kinetic resistance to anticancer agents....Pages 347-356
Cytochromes P450 and drug resistance....Pages 357-366
Role of matrix metalloproteinases in invasion and metastasis: biology, diagnosis and inhibitors....Pages 367-384
Clinical significance of cellular resistance in tumours to cytotoxic chemotherapy and radiotherapy....Pages 385-391
Back Matter....Pages 393-393

---

This book is an up-to-date review of current knowledge in the field of multiple drug resistance in human cancer. The literature up to the middle of 1993 is surveyed in specialist chapters written by different experts. Topics covered include the molecular genetics, cytogenetics and biochemistry of the mdr genes and P-glycoprotein; alternative transport proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione- S-transferases in MDR; cellular models for MDR in solid tumours and haemopoietic tumours; immunochemical and molecular biological techniques for detection of MDR-related gene expression; and clinical and pharmacological strategies to circumvent resistance. The book brings together a new combination of approaches to this serious clinical problem.

Content:
Front Matter....Pages i-viii
P-glycoprotein structure and evolutionary homologies....Pages 1-32
Molecular analysis of the multidrug transporter....Pages 33-62
Molecular cytogenetics of multiple drug resistance....Pages 63-89
Antibodies in the study of multiple drug resistance....Pages 91-107
Non-P-glycoprotein multidrug resistance in cell lines which are defective in the cellular accumulation of drug....Pages 109-125
Topoisomerase I in multiple drug resistance....Pages 127-135
Topoisomerase II in multiple drug resistance....Pages 137-154
Glutathione-related enzymes, glutathione and multidrug resistance....Pages 155-170
Pharmacologic circumvention of multidrug resistance....Pages 171-212
Multidrug resistance (MDR) genes in haematological malignancies....Pages 213-230
Human cell lines as models for multidrug resistance in solid tumours....Pages 231-256
Studies on low-level MDR cells....Pages 257-264
Differing patterns of cross-resistance resulting from exposures to specific antitumour drugs or to radiation in vitro ....Pages 265-288
The use of reverse transcriptase-polymerase chain reaction (RT-PCR) to investigate specific gene expression in multidrug-resistant cells....Pages 289-314
Mathematical models for multidrug resistance and its reversal....Pages 315-324
The biology of radioresistance: similarities, differences and interactions with drug resistance....Pages 325-345
Kinetic resistance to anticancer agents....Pages 347-356
Cytochromes P450 and drug resistance....Pages 357-366
Role of matrix metalloproteinases in invasion and metastasis: biology, diagnosis and inhibitors....Pages 367-384
Clinical significance of cellular resistance in tumours to cytotoxic chemotherapy and radiotherapy....Pages 385-391
Back Matter....Pages 393-393
....