Ebook: Cellular Bioenergetics: Role of Coupled Creatine Kinases

Most of the information on the functional role, structure and molecular biology of creatine kinase is scattered in several hundreds of publications. The editors of this volume invited all authors who are most active at present in experimental research on creatine kinases to summarize their work and make the information easily available to a wider scientific audience, especially to young investigators who are entering this field. Since the functional role of coupled creatine kinases is directly related to the phenomenon of compartmentation and structural organization of metabolic networks, we also invited experts in the related areas to contribute to the volume. Almost all invited authors responded enthusiastically and the results of this collective work are presented here.
For biochemists, biophysicists, physiologists, and medical research workers.

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Content:
Front Matter....Pages i-v
Introduction: history of the problem....Pages 1-1
Front Matter....Pages 3-3
Introduction: history of the problem....Pages 5-8
A brief summary of the history of the detection of creatine kinase isoenzymes....Pages 9-11
Metabolic regulation of in vivo myocardial contractile function: multiparameter analysis....Pages 13-37
Compartmentation of ATP synthesis and utilization in smooth muscle: roles of aerobic glycolysis and creatine kinase....Pages 39-50
Creatine metabolism and the consequences of creatine depletion in muscle....Pages 51-66
Front Matter....Pages 67-67
The importance of the outer mitochondrial compartment in regulation of energy metabolism....Pages 69-83
The influence of the cytosolic oncotic pressure on the permeability of the mitochondrial outer membrane for ADP: implications for the kinetic properties of mitochondrial creatine kinase and for ADP channelling into the intermembrane space....Pages 85-104
Influence of mitochondrial creatine kinase on the mitochondrial/extramitochondrial distribution of high energy phosphates in muscle tissue: evidence for a leak in the creatine shuttle....Pages 105-113
The structure of mitochondrial creatine kinase and its membrane binding properties....Pages 115-123
Myofibrillar creatine kinase and cardiac contraction....Pages 125-144
Interaction of creatine kinase and adenylate kinase systems in muscle cells....Pages 145-152
Front Matter....Pages 153-153
Metabolic compartmentation and substrate channelling in muscle cells....Pages 155-192
Creatine kinase in non-muscle tissues and cells....Pages 193-220
The creatine kinase system in smooth muscle....Pages 221-232
Front Matter....Pages 233-233
Expression of the mitochondrial creatine kinase genes....Pages 235-243
Sequence homology and structure predictions of the creatine kinase isoenzymes....Pages 245-262
Approaching the multifaceted nature of energy metabolism: inactivation of the cytosolic creatine kinases via homologous recombination in mouse embryonic stem cells....Pages 263-274
Front Matter....Pages 275-275
Compartmentation of creatine kinases during perinatal development of mammalian heart....Pages 277-286
Front Matter....Pages 287-298
Thyroid hormones and the creatine kinase system in cardiac cells....Pages 275-275
Front Matter....Pages 299-309
Control theory of metabolic channelling....Pages 311-311
Mathematical modeling of intracellular transport processes and the creatine kinase systems: a probability approach....Pages 313-331
....Pages 333-346