Ebook: ADP-Ribosylation: Metabolic Effects and Regulatory Functions

Considering the current interest in cellular regulation and intracellular signalling systems, it is surprising that the contribution of ADP-ribosylation reactions to the modulation of a variety of specific cell processes, in parallel with other post-translational modifications such as phosphorylation, has not been generally recognized. While it is not feasible to cover all aspects of ADP-ribosylation, the thirty-one articles contained in this volume provide a valuable overview of recent progress in the field within the context of cell control mechanisms. For the convenience of the reader, the various topics have been grouped into several sections: (a) poly(ADP-ribosyl)ation; (b) mono-ADP-ribosylation; (c) toxin mono-ADP-ribosylation; (d) inhibitors and activators; (e) protein modification with ADP-ribose and its analogues; and (f) non-modification forms of ADP-ribose. The contents of the individual chapters reflect the ideas of the contributors, many of whom have spent their careers attempting to resolve the biological functions of ADP-ribosylation. We hope that this publication will serve as a useful reference for those investigators that are new to the area as well as those who are actively studying ADP-ribosylation.

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Considering the current interest in cellular regulation and intracellular signalling systems, it is surprising that the contribution of ADP-ribosylation reactions to the modulation of a variety of specific cell processes, in parallel with other post-translational modifications such as phosphorylation, has not been generally recognized. While it is not feasible to cover all aspects of ADP-ribosylation, the thirty-one articles contained in this volume provide a valuable overview of recent progress in the field within the context of cell control mechanisms. For the convenience of the reader, the various topics have been grouped into several sections: (a) poly(ADP-ribosyl)ation; (b) mono-ADP-ribosylation; (c) toxin mono-ADP-ribosylation; (d) inhibitors and activators; (e) protein modification with ADP-ribose and its analogues; and (f) non-modification forms of ADP-ribose. The contents of the individual chapters reflect the ideas of the contributors, many of whom have spent their careers attempting to resolve the biological functions of ADP-ribosylation. We hope that this publication will serve as a useful reference for those investigators that are new to the area as well as those who are actively studying ADP-ribosylation.

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Considering the current interest in cellular regulation and intracellular signalling systems, it is surprising that the contribution of ADP-ribosylation reactions to the modulation of a variety of specific cell processes, in parallel with other post-translational modifications such as phosphorylation, has not been generally recognized. While it is not feasible to cover all aspects of ADP-ribosylation, the thirty-one articles contained in this volume provide a valuable overview of recent progress in the field within the context of cell control mechanisms. For the convenience of the reader, the various topics have been grouped into several sections: (a) poly(ADP-ribosyl)ation; (b) mono-ADP-ribosylation; (c) toxin mono-ADP-ribosylation; (d) inhibitors and activators; (e) protein modification with ADP-ribose and its analogues; and (f) non-modification forms of ADP-ribose. The contents of the individual chapters reflect the ideas of the contributors, many of whom have spent their careers attempting to resolve the biological functions of ADP-ribosylation. We hope that this publication will serve as a useful reference for those investigators that are new to the area as well as those who are actively studying ADP-ribosylation.

Content:
Front Matter....Pages i-2
Front Matter....Pages 3-3
Poly(ADP-ribose): Historical perspective....Pages 5-12
Front Matter....Pages 13-13
Structure and function of poly(ADP-ribose) polymerase....Pages 15-24
Poly(ADP-ribose) polymerase: Structural conservation among different classes of animals and its implications....Pages 25-32
Enzymology of ADP-ribose polymer synthesis....Pages 33-37
Interaction of poly(ADP-ribose)polymerase with DNA polymerase ?....Pages 39-44
Poly(ADP-ribose) catabolism in mammalian cells....Pages 45-52
Histone shuttling by poly ADP-ribosylation....Pages 53-59
Growth-phase-dependent response to DNA damage in poly(ADP-ribose) polymerase deficient cell lines: basis for a new hypothesis describing the role of poly(ADP-ribose) polymerase in DNA replication and repair....Pages 61-69
The function of poly (ADP-ribosylation) in DNA breakage and rejoining....Pages 71-75
Poly(ADP-ribose) polymerase gene on chromosome 1q: Early role in differentiation linked replication; gene on human chromosome 13q: Marker of carcinogenesis....Pages 77-84
Poly(ADP-ribose) polymerase activity in intact or permeabilized leukocytes from mammalian species of different longevity....Pages 85-90
ADP-ribosylation and gene expression....Pages 91-98
Transcriptional regulation and autoregulation of the human gene for ADP-ribosyltransferase....Pages 99-104
Front Matter....Pages 105-105
Vertebrate mono-ADP-ribosyltransferases....Pages 107-112
Target protein for eucaryotic arginine-specific ADP-ribosyltransferase....Pages 113-118
ADP-ribosylarginine hydrolases....Pages 119-122
Reversible ADP-ribosylation as a mechanism of enzyme regulation in procaryotes....Pages 123-129
Cellular ADP-ribosylation of Elongation Factor 2....Pages 131-133
Characterization of botulinum C3-catalyzed ADP- ribosylation of rho proteins and identification of mammalian C3-like ADP-ribosyltransferase....Pages 135-140
ADP-ribosylation of the molecular chaperone GRP78/BiP....Pages 141-148
Front Matter....Pages 149-154
Diphtheria toxin-related cytokine fusion proteins: elongation factor 2 as a target for the treatment of neoplastic disease....Pages 151-156
ADP-ribosylation factors: a family of ~20-kDa guanine nucleotide-binding proteins that activate cholera toxin....Pages 157-166
Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins....Pages 167-176
Common structure of the catalytic sites of mammalian and bacterial toxin ADP-ribosyltransferases....Pages 177-181
Front Matter....Pages 183-183
Inhibitors and activators of ADP-ribosylation reactions....Pages 185-197
Front Matter....Pages 199-199
Nitric oxide and NAD-dependent protein modification....Pages 201-206
Glycation of proteins by ADP-ribose....Pages 207-212
DeoxyNAD and deoxyADP-ribosylation of proteins....Pages 213-219
Enzymatic and nonenzymatic ADP-ribosylation of cysteine....Pages 221-226
Front Matter....Pages 227-227
NAD Glycohydrolases: A possible function in calcium homeostasis....Pages 229-235
NAD hydrolysis: Chemical and enzymatic mechanisms....Pages 237-243
Back Matter....Pages 245-251
....Pages 253-255