Ebook: Ion Channels and Ion Pumps: Metabolic and Endocrine Relationships in Biology and Clinical Medicine

This monograph assembles an international array of leading clinicians and researchers to present the current body of knowledge on the molecular structure of ion channels and their function, using such techniques as voltage clamping and single channel recording, measurements of gating currents, molecular cloning and other genetic manipulations. The monograph provides the information needed to understand the role that the movement of ions has in the function and malfunction of essentially all organ systems. This monograph will impress upon the reader the multiple and interdependent responses of ion channels to physiologic stimuli, pharmacologic agonists and agents of disease and their multiple interdependent roles in diverse physiologic processes, including the regulation of electrolyte and water balance and arterial pressure, in the maintenance of endocrine and metabolic homeostasis, in the control of neuromuscular responses, in the action of anesthetic drugs, in the pathogenesis of the recently described Syndrome X (obesity, hypertension, and diabetes), and in their antibacterial effectiveness. This volume is for all clinicians and researchers interested in the far reaching effects of the various, diverse roles of ion channels, their intricate structure, and their complex functions.

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This monograph assembles an international array of leading clinicians and researchers to present the current body of knowledge on the molecular structure of ion channels and their function, using such techniques as voltage clamping and single channel recording, measurements of gating currents, molecular cloning and other genetic manipulations. The monograph provides the information needed to understand the role that the movement of ions has in the function and malfunction of essentially all organ systems. This monograph will impress upon the reader the multiple and interdependent responses of ion channels to physiologic stimuli, pharmacologic agonists and agents of disease and their multiple interdependent roles in diverse physiologic processes, including the regulation of electrolyte and water balance and arterial pressure, in the maintenance of endocrine and metabolic homeostasis, in the control of neuromuscular responses, in the action of anesthetic drugs, in the pathogenesis of the recently described Syndrome X (obesity, hypertension, and diabetes), and in their antibacterial effectiveness. This volume is for all clinicians and researchers interested in the far reaching effects of the various, diverse roles of ion channels, their intricate structure, and their complex functions.
Content:
Front Matter....Pages i-xv
The Molecular Structure and Gating of Calcium Channels....Pages 1-18
Calcium Signals in Cell Proliferation, Differentiation, and Death....Pages 19-58
Role of Calcium in Stimulus-Secretion Coupling in Exocrine Glands....Pages 59-90
Calcium Channels, the Pancreatic Islet, and Endocrine Secretion....Pages 91-97
Calcium Channels in Cells of the Anterior Pituitary....Pages 98-108
Role of Calcium in the Secretion of Atrial Natriuretic Peptide....Pages 109-115
Intracellular Ca2+ and Insulin Action: Possible Role in the Pathogenesis of Syndrome X....Pages 116-136
[Ca2+]i and Contraction of Arterial Smooth Muscle....Pages 137-150
Autoimmunity Against the Nicotinic Acetylcholine Receptor and the Presynaptic Calcium Channel at the Neuromuscular Junction....Pages 151-189
Clinical Pharmacology of Calcium Channels....Pages 190-225
Hormonal Modulation of Sodium Pump Activity: Identification of Second Messengers....Pages 226-240
Endogenous Regulation of Sodium Pump Activity....Pages 241-260
Structure, Gating, and Clinical Implications of the Potassium Channel....Pages 261-281
Potassium Channels in Skeletal Muscle....Pages 282-316
The Role of Potassium Ions in the Control of Heart Function....Pages 317-348
Nonrenal Potassium Homeostasis: Hypokalemia and Potassium Depletion—Role of Skeletal Muscle Potassium-Pump (Na+,K+- ATPase)....Pages 349-372
The Clinical Pharmacology of Potassium Channels....Pages 373-394
Ion Transport in Vascular Smooth Muscle and the Pathogenesis of Hypertension....Pages 395-417
Calcium Ion Homeostasis in the Aging Brain: Regulation of Voltage-Dependent Calcium Channels....Pages 418-435
Interactions of Ethanol with Ion Channels: Possible Implications for Mechanisms of Intoxication and Dependence....Pages 436-454
Structure and Function of Receptor-Mediated Chloride Channels in the Central Nervous System....Pages 455-462
Characterization of Ion Channels in the Central Nervous System: Insights from Radioligand Binding, Autoradiography, and In Situ Hybridization Histochemistry....Pages 463-499
Chloride Channels in Cystic Fibrosis....Pages 500-525
Cyclic Nucleotide-Activated Channels....Pages 526-548
Transport Systems for Arsenic, Antimony, and Cadmium Ions Encoded by Bacterial Plasmids....Pages 549-573
Back Matter....Pages 575-587

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This monograph assembles an international array of leading clinicians and researchers to present the current body of knowledge on the molecular structure of ion channels and their function, using such techniques as voltage clamping and single channel recording, measurements of gating currents, molecular cloning and other genetic manipulations. The monograph provides the information needed to understand the role that the movement of ions has in the function and malfunction of essentially all organ systems. This monograph will impress upon the reader the multiple and interdependent responses of ion channels to physiologic stimuli, pharmacologic agonists and agents of disease and their multiple interdependent roles in diverse physiologic processes, including the regulation of electrolyte and water balance and arterial pressure, in the maintenance of endocrine and metabolic homeostasis, in the control of neuromuscular responses, in the action of anesthetic drugs, in the pathogenesis of the recently described Syndrome X (obesity, hypertension, and diabetes), and in their antibacterial effectiveness. This volume is for all clinicians and researchers interested in the far reaching effects of the various, diverse roles of ion channels, their intricate structure, and their complex functions.
Content:
Front Matter....Pages i-xv
The Molecular Structure and Gating of Calcium Channels....Pages 1-18
Calcium Signals in Cell Proliferation, Differentiation, and Death....Pages 19-58
Role of Calcium in Stimulus-Secretion Coupling in Exocrine Glands....Pages 59-90
Calcium Channels, the Pancreatic Islet, and Endocrine Secretion....Pages 91-97
Calcium Channels in Cells of the Anterior Pituitary....Pages 98-108
Role of Calcium in the Secretion of Atrial Natriuretic Peptide....Pages 109-115
Intracellular Ca2+ and Insulin Action: Possible Role in the Pathogenesis of Syndrome X....Pages 116-136
[Ca2+]i and Contraction of Arterial Smooth Muscle....Pages 137-150
Autoimmunity Against the Nicotinic Acetylcholine Receptor and the Presynaptic Calcium Channel at the Neuromuscular Junction....Pages 151-189
Clinical Pharmacology of Calcium Channels....Pages 190-225
Hormonal Modulation of Sodium Pump Activity: Identification of Second Messengers....Pages 226-240
Endogenous Regulation of Sodium Pump Activity....Pages 241-260
Structure, Gating, and Clinical Implications of the Potassium Channel....Pages 261-281
Potassium Channels in Skeletal Muscle....Pages 282-316
The Role of Potassium Ions in the Control of Heart Function....Pages 317-348
Nonrenal Potassium Homeostasis: Hypokalemia and Potassium Depletion—Role of Skeletal Muscle Potassium-Pump (Na+,K+- ATPase)....Pages 349-372
The Clinical Pharmacology of Potassium Channels....Pages 373-394
Ion Transport in Vascular Smooth Muscle and the Pathogenesis of Hypertension....Pages 395-417
Calcium Ion Homeostasis in the Aging Brain: Regulation of Voltage-Dependent Calcium Channels....Pages 418-435
Interactions of Ethanol with Ion Channels: Possible Implications for Mechanisms of Intoxication and Dependence....Pages 436-454
Structure and Function of Receptor-Mediated Chloride Channels in the Central Nervous System....Pages 455-462
Characterization of Ion Channels in the Central Nervous System: Insights from Radioligand Binding, Autoradiography, and In Situ Hybridization Histochemistry....Pages 463-499
Chloride Channels in Cystic Fibrosis....Pages 500-525
Cyclic Nucleotide-Activated Channels....Pages 526-548
Transport Systems for Arsenic, Antimony, and Cadmium Ions Encoded by Bacterial Plasmids....Pages 549-573
Back Matter....Pages 575-587
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