Ebook: Phospholipids and Signal Transmission

Once Nietzsche said that human beings may be divided into two categories: Apollonians and Dionysians*. By this the philosopher meant that there are human beings a) who know what they are going to do in the long-term future (what we now call the grant application for the next 5 years), i. e. , Apollonians, and b) who barely know what they are going to do tomorrow morning before breakfast, i. e. , Dionysians. ** To organize a symposium, this symposium in particular, a committee had to be formed either of individuals sharing both Nietzschean characteristics or of individuals possessing either characteristic. Considering the rarity of the former type of subject, this organizing committee was spontaneously formed by a typical sample of both types of individuals. We first met in Perugia in 1988. Those of us who were Apollonians had thus a chance to organize a programme. The Dionysians knew what was going to happen to them, but, of course, did not know yet how to cope with it. They duly did so every day of the meeting, after breakfast. The organizers decided that it would be a useful exercise to assemble experts having different perspectives but all pursuing a very rapidly developing aspect of cell biology. They also hoped that these selected Apollonians and Dionysians would not merely recount their results but try to project the future through active interchanges of ideas and opinions with other attendees.

---

---

Content:
Front Matter....Pages I-XII
Glycosylphosphatidylinositol Anchored Recognition Molecules That Mediate Intercellular Adhesion and Promote Neurite Outgrowth....Pages 1-11
Lipid Synthesis and Targeting to the Mammalian Cell Surface....Pages 13-37
The Aminophospholipid Transporter from Human Red Blood Cells....Pages 39-48
Lipids (Composition and Topography) in Adrenal Chromaffin Granules and Their Relevance for the Function of These Organelles....Pages 49-59
Accelerated Cell Membrane Degradation in Alzheimer’s Disease Brain: Relationship to Amyloid Formation?....Pages 61-69
Mechanistic and Functional Aspects of Oscillatory Calcium Signalling....Pages 71-86
Phospholipid Hydrolysis and [Ca2+]i Control....Pages 87-93
Phosphoinositide Hydrolysis Indicates Functional Receptors in Astrocytes and in Neoplastic Cells from the Human CNS....Pages 95-105
The G-Proteins Regulating Phosphoinositide Breakdown....Pages 107-113
Actions and Interactions of Cholinergic and Excitatory Aminoacid Receptors on Phosphoinositide Signals, Excitotoxicity and Neuroplasticity....Pages 115-121
The Phospholipid Environment of Activated Synaptic Membrane Receptors May Provide Both Intracellularly and Retrogradely Acting Signals for the Regulation of Neuro(Muscular) Transmission....Pages 123-133
The Role of Arachidonic Acid as a Retrograde Messenger in Long-Term Potentiation....Pages 135-149
Resisting Memory Storage: Activating Endogenous Protein Kinease C Inhibitors....Pages 151-162
B-50 Phosphorylation in Response to Different Patterns of Electrical Stimulation in Rat Hippocampal Slices....Pages 163-170
Participation of Inositol Phosphates, Protein Kinase C, G-Proteins and Cyclic AMP in Signal Transduction in Primary Rat Astroglial Cultures....Pages 171-187
Sphingosine, a Breakdown Product of Cellular Sphingolipids, in Cellular Proliferation and Phospholipid Metabolism....Pages 189-203
Regulation of Phosphatidylserine Synthesis during T Cell Activation....Pages 205-218
Anti-Phosphatidylserine Monoclonal Antibody: Structural Template for Studying Lipid-Protein Interactions and for Identificationo of Phosphatidylserine Binding Proteins....Pages 219-234
Immunomodulation by Serine Phospholipids....Pages 235-247
Direct Effect of Phosphatidylserine on the Activity of the Post-Synaptic GABAA Receptor Complex....Pages 249-256
Phosphatidylserine Reverses the Age-Dependent Decrease in Cortical Acetylcholine Release in the Rat....Pages 257-265
Control of Phosphatidylcholine Metabolism....Pages 267-279
The Conversion of Ethanolamine Containing Compounds to Choline Derivatives and Acetylcholine....Pages 281-299
Phospholipid Metabolism in a Human Cholinergic Cell Line — Possible Involvement of the Base Exchange Enzyme Activities....Pages 301-315
Disposition of Choline for the Brain....Pages 317-326
The Homeostasis of Brain Choline....Pages 327-340
Tacrine (Tetrahydroaminoacridine) and the Metabolism of Acetylcholine and Choline....Pages 341-351
CDPcholine, CDPethanolamine, Lipid Metabolism and Disorders of the Central Nervous System....Pages 353-372
Biosynthesis of 1-Alkyl-2-Acetyl-sn-Glycero-3-Phosphocholine (Platelet Activating Factor) in Cultured Neuronal and Glial Cells....Pages 373-385
PAF and Hypothalamic Secretions in the Rat....Pages 387-402
Activation of Phospholipid Hydrolysis and Generation of Eicosanoids in Cultured Rat Astroglial Cells by PAF, and Modulation by N-3 Fatty Acids....Pages 403-410
A Neural Primary Genomic Response to the Lipid Mediator Platelet-Activating Factor....Pages 411-426
Back Matter....Pages 427-452

---

Content:
Front Matter....Pages I-XII
Glycosylphosphatidylinositol Anchored Recognition Molecules That Mediate Intercellular Adhesion and Promote Neurite Outgrowth....Pages 1-11
Lipid Synthesis and Targeting to the Mammalian Cell Surface....Pages 13-37
The Aminophospholipid Transporter from Human Red Blood Cells....Pages 39-48
Lipids (Composition and Topography) in Adrenal Chromaffin Granules and Their Relevance for the Function of These Organelles....Pages 49-59
Accelerated Cell Membrane Degradation in Alzheimer’s Disease Brain: Relationship to Amyloid Formation?....Pages 61-69
Mechanistic and Functional Aspects of Oscillatory Calcium Signalling....Pages 71-86
Phospholipid Hydrolysis and [Ca2+]i Control....Pages 87-93
Phosphoinositide Hydrolysis Indicates Functional Receptors in Astrocytes and in Neoplastic Cells from the Human CNS....Pages 95-105
The G-Proteins Regulating Phosphoinositide Breakdown....Pages 107-113
Actions and Interactions of Cholinergic and Excitatory Aminoacid Receptors on Phosphoinositide Signals, Excitotoxicity and Neuroplasticity....Pages 115-121
The Phospholipid Environment of Activated Synaptic Membrane Receptors May Provide Both Intracellularly and Retrogradely Acting Signals for the Regulation of Neuro(Muscular) Transmission....Pages 123-133
The Role of Arachidonic Acid as a Retrograde Messenger in Long-Term Potentiation....Pages 135-149
Resisting Memory Storage: Activating Endogenous Protein Kinease C Inhibitors....Pages 151-162
B-50 Phosphorylation in Response to Different Patterns of Electrical Stimulation in Rat Hippocampal Slices....Pages 163-170
Participation of Inositol Phosphates, Protein Kinase C, G-Proteins and Cyclic AMP in Signal Transduction in Primary Rat Astroglial Cultures....Pages 171-187
Sphingosine, a Breakdown Product of Cellular Sphingolipids, in Cellular Proliferation and Phospholipid Metabolism....Pages 189-203
Regulation of Phosphatidylserine Synthesis during T Cell Activation....Pages 205-218
Anti-Phosphatidylserine Monoclonal Antibody: Structural Template for Studying Lipid-Protein Interactions and for Identificationo of Phosphatidylserine Binding Proteins....Pages 219-234
Immunomodulation by Serine Phospholipids....Pages 235-247
Direct Effect of Phosphatidylserine on the Activity of the Post-Synaptic GABAA Receptor Complex....Pages 249-256
Phosphatidylserine Reverses the Age-Dependent Decrease in Cortical Acetylcholine Release in the Rat....Pages 257-265
Control of Phosphatidylcholine Metabolism....Pages 267-279
The Conversion of Ethanolamine Containing Compounds to Choline Derivatives and Acetylcholine....Pages 281-299
Phospholipid Metabolism in a Human Cholinergic Cell Line — Possible Involvement of the Base Exchange Enzyme Activities....Pages 301-315
Disposition of Choline for the Brain....Pages 317-326
The Homeostasis of Brain Choline....Pages 327-340
Tacrine (Tetrahydroaminoacridine) and the Metabolism of Acetylcholine and Choline....Pages 341-351
CDPcholine, CDPethanolamine, Lipid Metabolism and Disorders of the Central Nervous System....Pages 353-372
Biosynthesis of 1-Alkyl-2-Acetyl-sn-Glycero-3-Phosphocholine (Platelet Activating Factor) in Cultured Neuronal and Glial Cells....Pages 373-385
PAF and Hypothalamic Secretions in the Rat....Pages 387-402
Activation of Phospholipid Hydrolysis and Generation of Eicosanoids in Cultured Rat Astroglial Cells by PAF, and Modulation by N-3 Fatty Acids....Pages 403-410
A Neural Primary Genomic Response to the Lipid Mediator Platelet-Activating Factor....Pages 411-426
Back Matter....Pages 427-452
....