Ebook: Cell Adhesion Molecules: Cellular Recognition Mechanisms

The Fourth Annual Pezcoller Symposium entitled Adhesion Molecules: Cellular Recognition Mechanisms was held in Rovereto, Italy, June 24-26, 1992 and was focussed on the detailed mechanisms whereby cells utilize certain integral membrane proteins to perceive their surrounding environment and interact with it. With timely presentations and stimulating discussions this Symposium addressed the genetics and biochemistry of adhesion molecules, the regulation of their functions and their role in cancer and the immune system. Emphasis was given to adhesion proteins in the integrin family because of the widespread distribution of this group of molecules and its important role in essentially all eukaryotic biological systems. The regulation of integrin genes and their expression are discussed in detail, as are specific aspects of the genetics of fibronectin. The molecular basis for the regulation of certain integrins, the function of these proteins in determining cell adhesion, and the consequences of this adhesion for the function of the cells involved are discussed. The role of certain integrins in stimulating signal transduction, the essential involvement of integrins in conditioning the function of T and NK cells function, the heterogeneity of integrins and its biological consequences, and the role of cell adhesion molecules in tumor cells invasion and metastases are all extensively analyzed. New information was presented on the role of CD44 and splice variants in normal differentiation and tumor progression.

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Integrin Expression and Epithelial Cell Differentiation; V. Quaranta. Fibronectin Mutations in Mice; E.N. Georges, et al. Extracellular and Intracellular Functions of VLA Proteins; M.E. Hemler, et al. Signal Transduction from Leukocyte Integrins; E.J. Brown. Coordinate Role for Proteoglycans and Integrins in Cell Adhesion; J.B. McCarthy, et al. Adhesion Molecules at Endothelial Cell to Cell Junctions; M.G.Lampugnani, et al. Activation of LFA1; C.G. Figdor, Y. van Kooyk. Interaction of Cytotoxic T Lymphocytes with Autologous Melanoma; A.Anichini, et al. Tumor Cell-Endothelial Cell Interactions during Blood Borne Metastasis; G.L. Nicolson, et al. Adhesion Mechanisms in Lymphoma and Carcinoma Metastasis; G. La Riviere, et al. CD44 and Splice Variants of CD44 in Normal Differentiation and Tumor Progression; P. Herrlich, et al. 6 additional articles. Index.

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Integrin Expression and Epithelial Cell Differentiation; V. Quaranta. Fibronectin Mutations in Mice; E.N. Georges, et al. Extracellular and Intracellular Functions of VLA Proteins; M.E. Hemler, et al. Signal Transduction from Leukocyte Integrins; E.J. Brown. Coordinate Role for Proteoglycans and Integrins in Cell Adhesion; J.B. McCarthy, et al. Adhesion Molecules at Endothelial Cell to Cell Junctions; M.G.Lampugnani, et al. Activation of LFA1; C.G. Figdor, Y. van Kooyk. Interaction of Cytotoxic T Lymphocytes with Autologous Melanoma; A.Anichini, et al. Tumor Cell-Endothelial Cell Interactions during Blood Borne Metastasis; G.L. Nicolson, et al. Adhesion Mechanisms in Lymphoma and Carcinoma Metastasis; G. La Riviere, et al. CD44 and Splice Variants of CD44 in Normal Differentiation and Tumor Progression; P. Herrlich, et al. 6 additional articles. Index.
Content:
Front Matter....Pages i-x
Transcriptional Regulation of the ?II? Integrin Gene....Pages 1-11
Integrin Expression and Epithelial Cell Differentiation....Pages 13-27
Fibronectin Mutations in Mice....Pages 29-39
General Discussion -- Session I....Pages 41-43
Regulation of ?1 Integrin-Mediated Adhesive Functions....Pages 45-61
Elements for a Structural/Functional Model of Human Platelet Plasma Membrane Fibrinogen Receptor, the Glycoprotein IIb/IIIa Complex (Integrin ?IIb/?3)....Pages 63-91
Extracellular and Intracellular Functions of vla Proteins....Pages 93-104
Signal Transduction from Leukocyte Integrins....Pages 105-125
Coordinate Role for Proteoglycans and Integrins in Cell Adhesion....Pages 127-147
Adhesion Molecules at Endothelial Cell to Cell Junctions....Pages 149-163
Regulation of T Cell Adhesion with T Cell Differentiation and with Acute Activation by Mip-l? Cytokine Immobilized on CD44 Proteoglycan....Pages 165-179
Activation of Lfa-1: The L16 Epitope is a Cation-Binding Reporter....Pages 181-194
Activation-Dependent Regulation of ?1 Integrin Expression and Function in Human Natural Killer Cells....Pages 195-208
Interaction of Cytotoxic T Lymphocytes with Autologous Melanoma: Role of Adhesion Molecules and ?1 Integrins....Pages 209-219
Tumor Cell-Endothelial Cell Interactions During Blood Borne Metastasis: Role of Specific Adhesion, Motility, and Growth Molecules....Pages 221-243
Adhesion Mechanisms in Lymphoma and Carcinoma Metastasis....Pages 245-264
Cd44 and Splice Variants of Cd44 in Normal Differentiation and Tumor Progression....Pages 265-288
Back Matter....Pages 289-294

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Integrin Expression and Epithelial Cell Differentiation; V. Quaranta. Fibronectin Mutations in Mice; E.N. Georges, et al. Extracellular and Intracellular Functions of VLA Proteins; M.E. Hemler, et al. Signal Transduction from Leukocyte Integrins; E.J. Brown. Coordinate Role for Proteoglycans and Integrins in Cell Adhesion; J.B. McCarthy, et al. Adhesion Molecules at Endothelial Cell to Cell Junctions; M.G.Lampugnani, et al. Activation of LFA1; C.G. Figdor, Y. van Kooyk. Interaction of Cytotoxic T Lymphocytes with Autologous Melanoma; A.Anichini, et al. Tumor Cell-Endothelial Cell Interactions during Blood Borne Metastasis; G.L. Nicolson, et al. Adhesion Mechanisms in Lymphoma and Carcinoma Metastasis; G. La Riviere, et al. CD44 and Splice Variants of CD44 in Normal Differentiation and Tumor Progression; P. Herrlich, et al. 6 additional articles. Index.
Content:
Front Matter....Pages i-x
Transcriptional Regulation of the ?II? Integrin Gene....Pages 1-11
Integrin Expression and Epithelial Cell Differentiation....Pages 13-27
Fibronectin Mutations in Mice....Pages 29-39
General Discussion -- Session I....Pages 41-43
Regulation of ?1 Integrin-Mediated Adhesive Functions....Pages 45-61
Elements for a Structural/Functional Model of Human Platelet Plasma Membrane Fibrinogen Receptor, the Glycoprotein IIb/IIIa Complex (Integrin ?IIb/?3)....Pages 63-91
Extracellular and Intracellular Functions of vla Proteins....Pages 93-104
Signal Transduction from Leukocyte Integrins....Pages 105-125
Coordinate Role for Proteoglycans and Integrins in Cell Adhesion....Pages 127-147
Adhesion Molecules at Endothelial Cell to Cell Junctions....Pages 149-163
Regulation of T Cell Adhesion with T Cell Differentiation and with Acute Activation by Mip-l? Cytokine Immobilized on CD44 Proteoglycan....Pages 165-179
Activation of Lfa-1: The L16 Epitope is a Cation-Binding Reporter....Pages 181-194
Activation-Dependent Regulation of ?1 Integrin Expression and Function in Human Natural Killer Cells....Pages 195-208
Interaction of Cytotoxic T Lymphocytes with Autologous Melanoma: Role of Adhesion Molecules and ?1 Integrins....Pages 209-219
Tumor Cell-Endothelial Cell Interactions During Blood Borne Metastasis: Role of Specific Adhesion, Motility, and Growth Molecules....Pages 221-243
Adhesion Mechanisms in Lymphoma and Carcinoma Metastasis....Pages 245-264
Cd44 and Splice Variants of Cd44 in Normal Differentiation and Tumor Progression....Pages 265-288
Back Matter....Pages 289-294
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