Ebook: Human Apolipoprotein Mutants III: Diagnosis and Treatment

Hopes to develop apolipoproteins for diagnostic or, even better, therapeuticpurposes are growing. Areas of use may range from arterial disease to AIDS, fertilization programs, neurological or inflammatory disorders, and the like. However, these young members of the large family of circulating proteins still deserve careful study, both in terms of structural and functional properties and of their pathological changes. In addition, related molecules, in particular belonging to the family of enzymes, such as lipases and acyltransferases, offer exciting insight into the mechanisms of regulation of lipid transport and exchange. Described hereis the use of apolipoproteins and enzymes in the diagnosis of coronary and cerebrovascular disease. Structural and functional changes of apolipoproteins are related to lipid transport and binding to different receptors. Further, the development of apolipoprotein drugs and their possible clinical use for vascular and non vascular disease is discussed and finally an overview on lipoprotein transformation processes, expression systems and natural mutants is provided.

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Hopes to develop apolipoproteins for diagnostic or, even better, therapeuticpurposes are growing. Areas of use may range from arterial disease to AIDS, fertilization programs, neurological or inflammatory disorders, and the like. However, these young members of the large family of circulating proteins still deserve careful study, both in terms of structural and functional properties and of their pathological changes. In addition, related molecules, in particular belonging to the family of enzymes, such as lipases and acyltransferases, offer exciting insight into the mechanisms of regulation of lipid transport and exchange. Described hereis the use of apolipoproteins and enzymes in the diagnosis of coronary and cerebrovascular disease. Structural and functional changes of apolipoproteins are related to lipid transport and binding to different receptors. Further, the development of apolipoprotein drugs and their possible clinical use for vascular and non vascular disease is discussed and finally an overview on lipoprotein transformation processes, expression systems and natural mutants is provided.

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Hopes to develop apolipoproteins for diagnostic or, even better, therapeuticpurposes are growing. Areas of use may range from arterial disease to AIDS, fertilization programs, neurological or inflammatory disorders, and the like. However, these young members of the large family of circulating proteins still deserve careful study, both in terms of structural and functional properties and of their pathological changes. In addition, related molecules, in particular belonging to the family of enzymes, such as lipases and acyltransferases, offer exciting insight into the mechanisms of regulation of lipid transport and exchange. Described hereis the use of apolipoproteins and enzymes in the diagnosis of coronary and cerebrovascular disease. Structural and functional changes of apolipoproteins are related to lipid transport and binding to different receptors. Further, the development of apolipoprotein drugs and their possible clinical use for vascular and non vascular disease is discussed and finally an overview on lipoprotein transformation processes, expression systems and natural mutants is provided.
Content:
Front Matter....Pages I-XI
Lipoprotein lipase: Gene variants and coronary atherosclerosis....Pages 1-11
Apolipoproteins in the Diagnosis of Disease: Cerebral and Peripheral Atherosclerosis....Pages 13-20
Functional Properties of Discoidal Apoprotein/Phospholipid Complexes: Cholesterol Efflux from Macrophages and Conversion by Lecithin-Cholesterol Acyl Transferase....Pages 21-30
Lipid Transport by Apolipoprotein AI: Structure and Function....Pages 31-41
Characterization of Lipoprotein Particles Containing Apolipoprotein A-IV....Pages 43-52
Structural and Functional Properties of Apo A-I Variants in Reconstituted HDL....Pages 53-65
Structural Domains in Human Serum Low Density Lipoprotein Apolipoprotein B100....Pages 67-79
Crystal Structures of the Common Apolipoprotein E Variants: Insights into Functional Mechanisms....Pages 81-96
Analysis of Apolipoprotein E Function in Adrenal Cells: Effects on Cholesterol Metabolism and Signal Transduction Pathways....Pages 97-106
Spontaneous Hypercholesterolemia in Pigs....Pages 107-112
The Apolipoprotein E Cys-142 Mutant: Role in Dominant Inheritance of Type III Hyperlipoproteinemia and Expression in Transgenic Mice....Pages 113-120
Apolipoproteins as “Drugs”: Current Status....Pages 121-133
Non-Mammalian Host Systems for the Expression of Mammalian Apolipoproteins....Pages 135-143
Recombinant Human Proapolipoprotein A-I: Experimental Strategies for the Production of an Authentic Molecule....Pages 145-163
The Role of HDL Apolipoproteins in Mediating HDL Receptor Binding and Intracellular Cholesterol Efflux....Pages 165-173
The Metabolism of Truncated Forms of Apolipoprotein B in Hypobetalipoproteinemia....Pages 175-182
Apolipoprotein B: Genetic Variants Provide Insight into Structure and Function....Pages 183-194
Causes Underlying the Reduced Response to Simvastatin Treatment in Hypercholesterolemic Patients....Pages 195-206
Molecular Genetics of the Familial Chylomicronemia Syndrome....Pages 207-229
Rare mutations in the APOE gene associated with dominant mode of inheritance of Familial Dysbetalipoproteinemia (FD)....Pages 231-239
Identification of Common Genetic Polymorphisms that Determine Plasma Levels of ApoAI and HDL-C....Pages 241-246
Sex-Related Differences in the Phenotypic Expression of the Apolipoprotein A-IMilano Mutant....Pages 247-256
Human Apolipoprotein A-IV....Pages 257-265
Back Matter....Pages 267-277
....Pages 279-287