Ebook: Biological Barriers to Protein Delivery

In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the fields of pharmacology, cell biology, biochemistry, physiology, and immunology.

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In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the fields of pharmacology, cell biology, biochemistry, physiology, and immunology.

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In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the fields of pharmacology, cell biology, biochemistry, physiology, and immunology.
Content:
Front Matter....Pages i-xxv
Front Matter....Pages 1-1
The Paracellular Pathway....Pages 3-21
Ectopeptidases....Pages 23-50
Endosomal and Lysosomal Hydrolases....Pages 51-70
Protein Uptake and Cytoplasmic Access in Animal Cells....Pages 71-104
Front Matter....Pages 105-105
Transepithelial Transport of Proteins by Intestinal Epithelial Cells....Pages 107-129
Intraoral Peptide Absorption....Pages 131-160
Macromolecular Transport across Nasal and Respiratory Epithelia....Pages 161-178
Dermal Absorption of Peptides and Proteins....Pages 179-197
Rectal and Vaginal Absorption of Peptides and Proteins....Pages 199-227
Front Matter....Pages 229-229
Vascular Endothelial Barrier Function and Its Regulation....Pages 231-267
Transcytosis of Macromolecules through the Blood—Brain Fluid Barriers in Vivo ....Pages 269-296
Front Matter....Pages 297-297
Renal Uptake and Disposal of Proteins and Peptides....Pages 299-338
Mechanisms for the Hepatic Clearance of Oligopeptides and Proteins....Pages 339-408
The Immune System as a Barrier to Delivery of Protein Therapeutics....Pages 409-437
Front Matter....Pages 439-439
Extravasation and Interstitial Transport in Tumors....Pages 441-465
Tissue Barriers....Pages 467-486
Back Matter....Pages 487-495

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In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the fields of pharmacology, cell biology, biochemistry, physiology, and immunology.
Content:
Front Matter....Pages i-xxv
Front Matter....Pages 1-1
The Paracellular Pathway....Pages 3-21
Ectopeptidases....Pages 23-50
Endosomal and Lysosomal Hydrolases....Pages 51-70
Protein Uptake and Cytoplasmic Access in Animal Cells....Pages 71-104
Front Matter....Pages 105-105
Transepithelial Transport of Proteins by Intestinal Epithelial Cells....Pages 107-129
Intraoral Peptide Absorption....Pages 131-160
Macromolecular Transport across Nasal and Respiratory Epithelia....Pages 161-178
Dermal Absorption of Peptides and Proteins....Pages 179-197
Rectal and Vaginal Absorption of Peptides and Proteins....Pages 199-227
Front Matter....Pages 229-229
Vascular Endothelial Barrier Function and Its Regulation....Pages 231-267
Transcytosis of Macromolecules through the Blood—Brain Fluid Barriers in Vivo ....Pages 269-296
Front Matter....Pages 297-297
Renal Uptake and Disposal of Proteins and Peptides....Pages 299-338
Mechanisms for the Hepatic Clearance of Oligopeptides and Proteins....Pages 339-408
The Immune System as a Barrier to Delivery of Protein Therapeutics....Pages 409-437
Front Matter....Pages 439-439
Extravasation and Interstitial Transport in Tumors....Pages 441-465
Tissue Barriers....Pages 467-486
Back Matter....Pages 487-495
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