Ebook: Dendritic Cells in Fundamental and Clinical Immunology

These Proceedings contain the contributions of the participants of the Second International Symposium on Dendritic Cells that was held from the 1st to 25th of June 1992 in Amsterdam, the Netherlands. The First International Symposium on Dendritic Cells was organized as a Satellite symposium at the occasion of the 30th anniversary of the Japanese Reticuloendothelial Society by Dr. Y. Imai in Yamagata (Japan), in 1990. It was entitled "Dendritic Cells in Lymphoid Tissues," and focused primarily on the Interdigitating Cells (IDC), Epidermal Langerhans cells (LC) and Follicular Dendritic Cells (FDC) , from the point of view of human pathology. However, the concept of Dendritic Cell System, comprising the bone marrow derived IDC and LC but not the FDC, was based on animal experiments and mainly on in vitro experiments on isolated cells. In a report from the Reticuloendothelial Society Committee on Nomenclature in 1982, Tew, Thorbecke and Steinman had already characterized these different types of DC, but the gap between in vivo and in vitro function remained. In Amsterdam, the Symposium focused on the Role of Dendritic Cells in Fundamental and Clinical Immunology. First, recent developments in molecular biology of antigen presentation and cell biological aspects of signal transduction were discussed, in relation to the potential of DC to stimulate lymphocytes and to trigger their in vitro differentiation.

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Content:
Front Matter....Pages i-xvi
Dendritic Cells: Antigen Presentation, Accessory Function and Clinical Relevance....Pages 1-9
Endocytic Activity of Dendritic Cells is Similar to Other Antigen Presenting Cells....Pages 11-15
Immunocytochemical Characterization of Dendritic Cells....Pages 17-21
Requirements of Exogenous Protein Antigens for Presentation to CD4+ T lymphocytes By MHC Class II-Positive APC....Pages 23-27
Modulation of MHC Class II Determinants on Rat Langerhans Cells During Short Term Culture....Pages 29-34
A Dendritic Cell Specific Determinant Present In Endosomes Is Involved in the Presentation of Protein Antigens....Pages 35-39
Dendritic Cells are Potent Antigen-Presenting Cells for Microbial Superantigen....Pages 41-46
Divergent T-cell Cytokine Profiles Induced by Dendritic Cells from Different Tissues....Pages 47-52
Adhesion Molecules: Co-Stimulators and Co-Mitogens in Dendritic Cell - T Cell Interaction....Pages 53-58
Dendritic Cell Dependent Expression of IgA By Clones in T/B Microcultures....Pages 59-64
Adhesion Molecules in Tonsil DC-T Cell Interactions....Pages 65-69
Dendritic Cells Have Reduced Cell Surface Membrane Glycoproteins Including CD43 Determinants....Pages 71-73
The Effect of Human Dendritic Cells on the Lectin-Induced Responsiveness of CD4+ T Cells To IL-2 and IL-4....Pages 75-80
Analysis of Cytokine and Cytokine Receptor Production by Human Dendritic Cells....Pages 81-85
Costimulating Factors and Signals Relevant for Antigen Presenting Cell Function....Pages 87-92
Distinct T Cell Stimulation Mechanism and Phenotype of Human Blood Dendritic Cells....Pages 93-98
The Role Of Dendritic Cells in the Regulation of T Cell Cytokine Synthesis....Pages 99-104
The Role of Dendritic Cells as Co-Stimulators in Tolerance Induction....Pages 105-110
The Influence of Dendritic Cells on T-Cell Cytokine Production....Pages 111-115
Phenotypical and Functional Characterization of Dendritic Cells in the Human Peritoneal Cavity....Pages 117-122
Dendritic Cells Isolated From Rat and Human Non-Lymphoid Tissue are Very Potent Accessory Cells....Pages 123-127
Antigen Presenting Capacity of Peritoneal Macrophages and Dendritic Cells....Pages 129-134
T-Cell Repertoire Development in MHC Class II Deficient Humans....Pages 135-140
Rat Thymic Dendritic Cells....Pages 141-146
Rat Thymic Dendritic Cells: Flow Cytometry Analysis....Pages 147-152
Ultrastructure of Interdigitating Cells in the Rat Thymus During Cyclosporin A Treatment....Pages 153-157
T Cell Tolerance and Antigen Presenting Cell Function in the Thymus....Pages 159-164
Tolerizing Mice to Human Leukocytes: A Step Toward the Production of Monoclonal Antibodies Specific for Human Dendritic Cells....Pages 165-172
Morphological and Functional Differences Between HLA-DR+ Peripheral Blood Dendritic Cells and HLA-DR+ FN-Alpha Producing Cells....Pages 173-178
Three Monoclonal Antibodies to Antigen Presenting Cells in the Rat with Differential Influence on Cellular Interactions....Pages 179-184
The MHC Expression of Dendritic Cells from Mouse Spleen Isolated by Centrifugal Elutriation is Upregulated During Short Term Culture....Pages 185-189
IL-6 and Its High Affinity Receptor During Differentiation of Monocytes into Langerhans Cells....Pages 191-198
Phagocytosis of Antigens by Langerhans Cells....Pages 199-204
Dissection of Human Langerhans Cell Allostimulatory Function. Modulation by Interferon-?.....Pages 205-208
Human in Vitro T Cell Sensitization Using Hapten-Modified Epidermal Langerhans Cells....Pages 209-212
Monocyte-Derived Langerhans Cells from Different Species - Morphological and Functional Characterization....Pages 213-218
A Serial Section Study on Mice Langerhans Cell Granules After DNFB Painting....Pages 219-224
Skin Dendritic Cell - Lymphocyte Interactions in Autologous System....Pages 225-230
Induction of the Low Affinity Receptor for IgE (Fc?RII/CD23) on Human Blood Dendritic Cells by Interleukin-4....Pages 231-236
Fc?RI Mediates IgE-Binding to Human Epidermal Langerhans Cells....Pages 237-241
Murine Epidermal Langerhans Cells as A Model to Study Tissue Dendritic Cells....Pages 243-249
Differentiation of Dendritic Cells in Cultures of Rat and Mouse Bone Marrow Cells....Pages 251-255
TNF and GM-CSF Dependent Growth of an Early Progenitor of Dendritic Langerhans Cells in Human Bone Marrow....Pages 257-262
Human Bone Marrow Contains Potent Stimulatory Cells for the Allogeneic MLR With the Phenotype of Dendritic Cells....Pages 263-268
Recombinant GM-CSF Induces in Vitro Differentiation of Dendritic Cells from Mouse Bone Marrow....Pages 269-273
Signals Required for Differentiating Dendritic Cells from Human Monocytes in Vitro....Pages 275-280
Down-Regulation and Release of CD14 On Human Monocytes by IL-4 Depends on the Presence of Serum Or GM-CSF....Pages 281-286
Serum-Free Differentiation of Rat and Human Dendritic Cells, Accompanied by Acquisition of the Nuclear Lamins A/C as Differentiation Markers....Pages 287-291
Immunophenotypic and Ultrastructural Differentiation and Maturation of Nonlymphoid Dendritic Cells in Osteopetrotic (op) Mice with the Total Absence of Macrophage Colony Stimulating Factor Activity....Pages 293-297
Loading of Dendritic Cells with Antigen in Vitro Or in Vivo by Immunotargeting can Replace the Need for Adjuvant....Pages 299-303
Migration of Alveolar Macrophages from Alveolar Space to Paracortical T Cell Area of the Draining Lymph Node....Pages 305-310
Comparison of Langerhans Cells and Interdigitating Reticulum Cells....Pages 311-314
Migration of Dendritic Cells During Contact Sensitization....Pages 315-320
Peritoneal Cell Labelling: A Study on the Migration of Macrophages and Dendritic Cells Towards the GUT....Pages 321-326
Dendritic Cells “in Vivo”: Migration and Antigen Handling....Pages 327-332
Follicular Dendritic Cells: Isolation Procedures, Short and Long Term Cultures....Pages 333-338
Heterogeneity and Cellular Origin of Follicular Dendritic Cells....Pages 339-344
Differential Uptake and Trapping of TI-2 Antigens: an Unexpected Role for Follicular Dendritic Cells in the Induction of TI-2 Immune Responses....Pages 345-351
Ultrastructural Heterogeneity of Follicular Dendritic Cells in the Human Tonsil....Pages 353-358
Ultrastructural Analysis of Human Lymph Node Follicles After HIV-1 Infection....Pages 359-363
Emperipolesis of Lymphoid Cells by Human Follicular Dendritic Cells in Vitro....Pages 365-370
The Localization of Lymphokines in Murine Germinal Centers....Pages 371-376
Two Different Mechanisms of Immune-Complex Trapping in the Mouse Spleen During Immune Responses....Pages 377-382
Cellular Requirements for Functional Reconstitution of Follicular Dendritic Cells in Scid Mice....Pages 383-386
Interaction Through the Lfa-1/Icam-1 Pathway Prevents Programmed Cell Death of Germinal Center B Cells....Pages 387-392
Membrane Expression of Fc?RII/CD23 and Release of Soluble CD23 by Follicular Dendritic Cells....Pages 393-398
Follicular Dendritic Cells in Malignant Lymphomas - Distribution, Phenotypes & Ultrastructures....Pages 399-404
Lymphoid Follicles in Cynomolgus Monkeys after Infection with Simian Immunodeficiency Virus....Pages 405-409
Destruction of Follicular Dendritic Cells in Murine Acquired Immunodeficiency Syndrome (Maids)....Pages 411-416
Rapid and Selective Isolation of Follicular Dendritic Cells by Low Speed Centrifugations on Discontinuous BSA Gradients....Pages 417-423
Follicular Dendritic Cells Do Not Produce TNF-? Nor its Receptor....Pages 425-429
Splenic Lesions in Hypogammaglobulinaemia....Pages 431-436
Ontogenic Study on the Bronchus-Associated Lymphoid Tissue (Balt) in the Rat, with Special Reference to Dendritic Cells....Pages 437-441
DRC1 Expression on Normal and Pathological Lymphoid Cells....Pages 443-447
Binding of HIV-1 to Human Follicular Dendritic Cells....Pages 449-453
Follicular Dendritic Cells in Germinal Center Reactions....Pages 455-460
Follicular Dendritic Cells and Dendritic Cell Nomenclature....Pages 461-465
Langerhans Cells as Outposts of the Dendritic Cell System....Pages 467-468
Heterogeneity of Dendritic Cells and Nomenclature....Pages 469-480
Report of the Panel Discussion....Pages 481-486
Dendritic Cells in Transplantation....Pages 487-488
Down-Regulation of MHC-Expression on Dendritic Cells in Rat Kidney Grafts by Puva Pretreatment....Pages 489-494
Cytokine Mediators of Non-Lymphoid Dendritic Cell Migration....Pages 495-499
Isolation of Dendritic Leukocytes from Non-Lymphoid Organs....Pages 501-506
RT1B/D+ Non-Lymphoid DC in Early GVHD and Hg-Induced Autoimmunity of Rat Salivary and Lacrimal Glands....Pages 507-512
In-Vitro Infection of Peripheral Blood Dendritic Cells with Human Immunodeficiency Virus-1 Causes Impairment of Accessory Functions....Pages 513-519
Simian Immunodeficiency Virus (SIV) Induced Alterations of Thymus IDCs....Pages 521-526
Murine Leukaemia Virus Infections as Models For Retroviral Disease in Humans....Pages 527-531
Langerhans Cells and Interdigitating Cells in Hiv-Infection....Pages 533-537
Dendritic Cells in HIV-1 and HTLV-1 Infection....Pages 539-544
Dendritic Cells in Allergic and Chronic Inflammatory Responses....Pages 545-549
Pulmonary Dendritic Cell Populations....Pages 551-555
Blood Dendritic Cells are Highly Adherent to Untreated and Cytokine-Treated Cultured Endothelium....Pages 557-562
Antigen Specific T Cell Priming in Vivo by Intratracheal Injection of Antigen Presenting Cells....Pages 563-569
Histology and Immunophenotype of Dendritic Cells in the Human Lung....Pages 571-575
Acquisition of Chlamydial Antigen by Dendritic Cells and Monocytes....Pages 577-580
Experimental Cutaneous Leishmaniasis: Langerhans Cells Internalize Leishmania Major and Induce an Antigen-Specific T-Cell Response....Pages 581-586
Endocytosis of Potential Contact Sensitizers by Human Dendritic Cells....Pages 587-592
Dendritic Cells and “Dendritic” Macrophages in the Uveal Tract....Pages 593-597
Macrophages and Dendritic Cells in Rat Colon in Experimental Inflammatory Bowel Disease....Pages 599-604
Vaccination with Tumor Antigen-Pulsed Dendritic Cells Induces in Vivo Resistance to A B Cell Lymphoma....Pages 605-610
Studies on Langerhans Cells in the Tracheal Squamous Metaplasia of Vitamin A Deficient Rats....Pages 611-616
Depletion of Langerhans Cells Following Carcinogen Treatment is Partly Due to Antigenicity....Pages 617-621
A Proportion of Patients with Premature Ovarian Failure Show Lowered Percentages of Blood Monocyte Derived Dendritic Cells Capable of Forming Clusters with Lymphocytes....Pages 623-627
Thyroid Hormones and Their Iodinated Breakdown Products Enhance the Capability of Monocytes to Mature Into Veiled Cells. Blocking Effects of ?-GM-CSF....Pages 629-632
Relationship Between Dendritic Cells and Folliculo-Stellate Cells in the Pituitary: Immunohistochemical Comparison Between Mouse, Rat and Human Pituitaries....Pages 633-636
Dendritic Cells in Tumor Growth and Endocrine Diseases....Pages 637-642
Back Matter....Pages 643-650
....Pages 651-653