Ebook: DNA-Protein Interactions
Author: Andrew Travers (auth.)
- Tags: Animal Anatomy / Morphology / Histology, Human Genetics
- Year: 1993
- Publisher: Springer Netherlands
- Edition: 1
- Language: English
- pdf
Our understanding of the mechanisms regulating gene expression, which determine the patterns of growth and development in all living organisms, ultimately involves the elucidation of the detailed and dy namic interactions of proteins with nucleic acids -both DNA and RNA. Until recently the commonly presented view of the DNA double helix as visualized on the covers of many textbooks and journals - was as a monotonous static straight rod incapable in its own right of directing the processes necessary for the conservation and selective reading of genetic information. This view, although perhaps extreme, was reinforced by the necessary linearity of genetic maps. The reality is that the biological functions of both DNA and RNA are dependent on complex, and sometimes transient, three-dimensional nucleoprotein structures in which genetically distant elements are brought into close spatial proximity. It is in such structures that the enzymatic manipulation of DNA in the essential biological processes as DNA replication, transcription and recombination are effected - the complexes are the mediators of the 'DNA transactions' of Hatch Echols.
The binding of proteins to DNA and the manipulation of DNA by proteins are crucial aspects of the biological role of DNA in the living cell. This book provides a comprehensive and lucid discussion of the molecular interactions involved.
The binding of proteins to DNA and the manipulation of DNA by proteins are crucial aspects of the biological role of DNA in the living cell. This book provides a comprehensive and lucid discussion of the molecular interactions involved.
Content:
Front Matter....Pages i-x
DNA structure....Pages 1-27
DNA—protein interactions: The three-dimensional architecture of DNA—protein complexes....Pages 28-51
DNA-protein interactions: sequence specific recognition....Pages 52-86
The mechanism of RNA chain initiation....Pages 87-108
The regulation of promoter selectivity in eubacteria....Pages 109-129
The mechanism of eukaryotic transcription....Pages 130-157
Chromatin and transcription....Pages 158-175
Back Matter....Pages 176-180
The binding of proteins to DNA and the manipulation of DNA by proteins are crucial aspects of the biological role of DNA in the living cell. This book provides a comprehensive and lucid discussion of the molecular interactions involved.
Content:
Front Matter....Pages i-x
DNA structure....Pages 1-27
DNA—protein interactions: The three-dimensional architecture of DNA—protein complexes....Pages 28-51
DNA-protein interactions: sequence specific recognition....Pages 52-86
The mechanism of RNA chain initiation....Pages 87-108
The regulation of promoter selectivity in eubacteria....Pages 109-129
The mechanism of eukaryotic transcription....Pages 130-157
Chromatin and transcription....Pages 158-175
Back Matter....Pages 176-180
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