Ebook: Mechanisms of Platelet Activation and Control

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Content:
Front Matter....Pages i-xiv
The Platelet as a Cа2+-Driven Cell: Mechanisms Which May Modulate Cа2+-Driven Responses....Pages 1-15
Agonist Receptors and G proteins as Mediators of Platelet Activation....Pages 17-36
Regulation of Phosphoinositide-Specific Phospholipase C Activity in Human Platelets....Pages 37-47
RAP1B and Platelet Function....Pages 49-55
Calcium Signalling and Phosphoinositide Metabolism in Platelets: Subsecond Events Revealed by Quenched-Flow Techniques....Pages 57-67
Calcium Influx Mechanisms and Signal Organisation in Human Platelets....Pages 69-82
Ca2+ Homeostasis and Intracellular Pools in Human Platelets....Pages 83-104
The Use of Inhibitors of Protein Kinases and Protein Phosphatases to Investigate the Role of Protein Phоsphorylation in Platelet Activation....Pages 105-118
Serine/Тhrеonine Kinases in Signal Transduction in Response to Thrombin in Human Platelets Use of 17—Hydroxywortmannin to Discriminate Signals....Pages 119-128
Tyrosine Phosphorylation in Platelets: Its Regulation and Possible Roles in Platelet Functions....Pages 129-148
Evidence That Activation of Phospholipase D can Mediate Secretion from Permeabilized Platelets....Pages 149-164
Inositol Lipid Metabolism, the Cytoskeleton, Glycoprotein IIb IIIa and Platelets....Pages 165-174
Regulation of Platelet Function by the Cytoskeleton....Pages 175-185
Cytoskeletal Interactions of Raplb in Platelets....Pages 187-194
Mechanisms Involved in Platelet Procoagulant Response....Pages 195-207
Histamine as an Intracellular Messenger in Human Platelets....Pages 209-219
Platelet Activation Via Binding of Monoclonal Antibodies to the Fc? Receptor II....Pages 221-228
Functional Relationship between Cyclic AMP-Dependent Protein ?hosphorylation and Platelet Inhibition....Pages 229-235
Role of Cyclic Nucleotide-Dependent Protein Kinases and Their Common Substrate VASP in the Regulation of Human Platelets....Pages 237-249
The Biological and Pharmacological Role of Nitric Oxide in Platelet Function....Pages 251-264
Back Matter....Pages 265-272

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Content:
Front Matter....Pages i-xiv
The Platelet as a Cа2+-Driven Cell: Mechanisms Which May Modulate Cа2+-Driven Responses....Pages 1-15
Agonist Receptors and G proteins as Mediators of Platelet Activation....Pages 17-36
Regulation of Phosphoinositide-Specific Phospholipase C Activity in Human Platelets....Pages 37-47
RAP1B and Platelet Function....Pages 49-55
Calcium Signalling and Phosphoinositide Metabolism in Platelets: Subsecond Events Revealed by Quenched-Flow Techniques....Pages 57-67
Calcium Influx Mechanisms and Signal Organisation in Human Platelets....Pages 69-82
Ca2+ Homeostasis and Intracellular Pools in Human Platelets....Pages 83-104
The Use of Inhibitors of Protein Kinases and Protein Phosphatases to Investigate the Role of Protein Phоsphorylation in Platelet Activation....Pages 105-118
Serine/Тhrеonine Kinases in Signal Transduction in Response to Thrombin in Human Platelets Use of 17—Hydroxywortmannin to Discriminate Signals....Pages 119-128
Tyrosine Phosphorylation in Platelets: Its Regulation and Possible Roles in Platelet Functions....Pages 129-148
Evidence That Activation of Phospholipase D can Mediate Secretion from Permeabilized Platelets....Pages 149-164
Inositol Lipid Metabolism, the Cytoskeleton, Glycoprotein IIb IIIa and Platelets....Pages 165-174
Regulation of Platelet Function by the Cytoskeleton....Pages 175-185
Cytoskeletal Interactions of Raplb in Platelets....Pages 187-194
Mechanisms Involved in Platelet Procoagulant Response....Pages 195-207
Histamine as an Intracellular Messenger in Human Platelets....Pages 209-219
Platelet Activation Via Binding of Monoclonal Antibodies to the Fc? Receptor II....Pages 221-228
Functional Relationship between Cyclic AMP-Dependent Protein ?hosphorylation and Platelet Inhibition....Pages 229-235
Role of Cyclic Nucleotide-Dependent Protein Kinases and Their Common Substrate VASP in the Regulation of Human Platelets....Pages 237-249
The Biological and Pharmacological Role of Nitric Oxide in Platelet Function....Pages 251-264
Back Matter....Pages 265-272
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