Ebook: Cellular Function and Metabolism

A variety of metabolic processes are known to be intimately involved in the maintenance of cellular structure and function. It has also become clear that metabolic events involved in the synthesis and hydrolysis of ATP as well as for the synthesis of proteins and phospholipids are essential for cellular health. The regulation of cell function is generally achieved through participation of a wide variety of hormones and different signal transduction mechanisms for the activation/deactivation of some specific metabolic processes. In this regard cyclic AMP and calcium seem to play a crucial role. Various hormones are also known to affect the genetic machinery of all the cell; however, the exact signals for genetic control of cellular function are not well defined. In particular, the sequence of events concerned with remodelling of different types of cells under various pathological situations is poorly understood. In this book we have therefore dealt with some of these issues from biochemical, molecular biological, physiological, and pharmacological viewpoints. Special emphasis has been laid on understanding heart function and metabolism in health and disease in general, and cardiac hypertrophy, heart failure, and ischemic heart disease in particular. It is hoped that this multidisciplinary information will be of value to basic scientists and clinical investigators.

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A variety of metabolic processes are known to be intimately involved in the maintenance of cellular structure and function. It has also become clear that metabolic events involved in the synthesis and hydrolysis of ATP as well as for the synthesis of proteins and phospholipids are essential for cellular health. The regulation of cell function is generally achieved through participation of a wide variety of hormones and different signal transduction mechanisms for the activation/deactivation of some specific metabolic processes. In this regard cyclic AMP and calcium seem to play a crucial role. Various hormones are also known to affect the genetic machinery of all the cell; however, the exact signals for genetic control of cellular function are not well defined. In particular, the sequence of events concerned with remodelling of different types of cells under various pathological situations is poorly understood. In this book we have therefore dealt with some of these issues from biochemical, molecular biological, physiological, and pharmacological viewpoints. Special emphasis has been laid on understanding heart function and metabolism in health and disease in general, and cardiac hypertrophy, heart failure, and ischemic heart disease in particular. It is hoped that this multidisciplinary information will be of value to basic scientists and clinical investigators.

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A variety of metabolic processes are known to be intimately involved in the maintenance of cellular structure and function. It has also become clear that metabolic events involved in the synthesis and hydrolysis of ATP as well as for the synthesis of proteins and phospholipids are essential for cellular health. The regulation of cell function is generally achieved through participation of a wide variety of hormones and different signal transduction mechanisms for the activation/deactivation of some specific metabolic processes. In this regard cyclic AMP and calcium seem to play a crucial role. Various hormones are also known to affect the genetic machinery of all the cell; however, the exact signals for genetic control of cellular function are not well defined. In particular, the sequence of events concerned with remodelling of different types of cells under various pathological situations is poorly understood. In this book we have therefore dealt with some of these issues from biochemical, molecular biological, physiological, and pharmacological viewpoints. Special emphasis has been laid on understanding heart function and metabolism in health and disease in general, and cardiac hypertrophy, heart failure, and ischemic heart disease in particular. It is hoped that this multidisciplinary information will be of value to basic scientists and clinical investigators.
Content:
Front Matter....Pages i-1
Control of Growth in Neonatal Pig Hearts....Pages 3-9
Role of Protein Kinase System in the Signal Transduction of Stretch-Mediated Protooncogene Expression and Hypertrophy of Cardiac Myocytes....Pages 11-16
Growth Factor for Cardiac Hypertrophy....Pages 17-22
Effect of Angiotensin Coverting Enzyme Inhibitor on Regression in Cardiac Hypertrophy....Pages 23-28
Differing Responses of G2-Related Genes During Differentiation of HL60 Cells Induced by TPA or DMSO....Pages 29-34
Mechanistic Effects of Kijimicin on Inhibition of Human Immunodeficiency Virus Replication....Pages 35-41
Function and Energy Metabolism of Isolated Hearts Obtained from Hyperthyroid Spontaneously Hypertensive Rats (SHR) A 31P-Nuclear Magnetic Resonance Study....Pages 43-50
Increased Calcium Release from Sarcoplasmic Reticulum Stimulated by Inositol Trisphosphate in Spontaneously Hypertensive Rat Heart Cells....Pages 51-57
Radial Spread of Aequorin Ca2+ Signal in Single Frog Skeletal Muscle Fibers....Pages 59-66
Cardiac Contractile Proteins and Autoimmune Myocarditis....Pages 67-71
Force-Frequency-Relation in Human Atrial and Ventricular Myocardium....Pages 73-78
Depressed Sliding Velocity of Isolated Cardiac Myosin from Cardiomyopathic Hamsters: Evidence for an Alteration in Mechanical Interaction of Actomyosin....Pages 79-88
Abnormalities of ADP/ATP Carrier Protein in J-2-N Cardiomyopathic Hamsters....Pages 89-94
Age-Associated Damage in Mitochondrial DNA in Human Hearts....Pages 95-103
Mitochondrial DNA Deletion in Human Myocardium....Pages 105-108
Ischemic changes in myocardial ionic eontents of the isolated perfused rat hearts as studied by NMR....Pages 109-120
Release of 6-KET0-PGFl? and thromboxane B2 in late appearing cardioprotection induced by the stable PGI analogue: 7-OXO-PGI....Pages 121-127
Effects of Iloprost, a PGI2 Derivative, on Ischemic Myocardial Energy and Carbohydrate Metabolism in Dogs....Pages 129-132
Cardioprotective Actions of Wild Garlic (Allium Ursinum) in Ischemia and Reperfusion....Pages 133-141
Na+/H+ Exchanger and Reperfusion-Induced Ventricular Arrhythmias in Isolated Perfused Heart: Possible Role of Amiloride....Pages 143-150
Effects of a New Class I Antiarrhythmic Drug Bidisomide on Canine Ventricular Arrhythmia Models....Pages 151-157
Antimicrobial Activity of Lipoprotein Particles Containing Apolipoprotein Al....Pages 159-169
Molecular Characteristics in Japanese Patients with Lipidosis: Novel Mutations in Metachromatic Leukodystrophy and Gaucher Disease....Pages 171-178
Characterization of Adenylyl Cyclase in Heart Sarcolemma in the Absence or Presence of Alamethicin....Pages 179-184
Cyclic AMP Metabolism in Intact Rat Ventricular Cardiac Myocytes: Interaction of Carbachol with Isoproterenol and 3-Isobutyl-L-Methylxanthine....Pages 185-193
Purification and Properties of Pyridoxal Kinase from Bovine Brain....Pages 195-201
Modulation of the Effect of Glibenclamide on KATP Channels by ATP and ADP....Pages 203-207
Back Matter....Pages 209-215
....Pages 217-220