Ebook: Macrophages and Related Cells
- Tags: Oncology, Hematology, Immunology, Biochemistry general, Human Genetics
- Series: Blood Cell Biochemistry 5
- Year: 1993
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
To produce a comprehensive overview of macrophages and related cell types in a short review volume is an impossible task. When I selected the topics to be included, some equally important areas were omitted by necessity, and for this I apologize. My choices have been somewhat eclectic, touching subjects of personal interest (such as osteoclast biology and macrophage electrophysiology) or of current fashion (apopto sis, antigen processing, cell adhesion molecules). The book has also had to encompass areas of a more general flavor to provide balance for the general reader (such as reviews of macrophage development, heterogeneity, and function, and of the surface molecules expressed by macrophages). I thank all the authors for their prompt sub missions; all have been of high quality, and my editorial tasks, thankfully, have been minimal. Michael A. Horton London, United Kingdom ix Contents Chapter J An Overview of Receptors of MPS Cells lain Fraser and Siam on Gordon 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. The Mononuclear Phagocyte System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 3. Diversity of Macrophage Plasma Membrane Receptors. . . . . . . . . . . . . . . . 6 3. 1 A Structural Approach to Classification . . . . . . . . . . . . . . . . . . . . . . . . . . 6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 2 Multisubunit Receptors 3. 3 Soluble Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3. 4 Lectins and Lectin-Like Receptors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 4. Functions and Selected Examples. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 4. 1 Growth, Differentiation, and Modulation . . . . . . . . . . . . . . . . . . . . . . . . 14 4. 2 Cell-Cell and Cell-Matrix Interactions. . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4. 3 Endocytosis and Scavenger Receptors. . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4. 4 Secretory Responses and Biosynthesis of Effector Molecules . . . . . . 17 5. Concluding Remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 6. References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 . . . . . . . . . . . . . . . . . . . .
Content:
Front Matter....Pages i-xix
An Overview of Receptors of MPS Cells....Pages 1-27
Heterogeneity of Mononuclear Phagocytes....Pages 29-85
Origin of Macrophages....Pages 87-113
Complement and the Mononuclear Phagocyte System....Pages 115-148
Macrophages and Prostaglandins....Pages 149-159
Antigen Processing....Pages 161-182
Antigens of Osteoclasts Phenotypic Definition of a Specialized Hemopoietic Cell Lineage....Pages 183-202
Electrophysiology of Osteoclasts and Macrophages....Pages 203-222
Complement Receptors....Pages 223-259
Fc? Receptors of Myeloid Cells....Pages 261-277
Matrix Receptors of Myeloid Cells....Pages 279-306
Leukocyte Integrins....Pages 307-333
Molecular Basis for Leukocyte Adhesion Molecule Deficiency....Pages 335-346
Carbohydrate-Recognition Proteins of Macrophages and Related Cells....Pages 347-370
Leukocyte Adhesion to Endothelium....Pages 371-392
Cell Recognition of Apoptotic Cells....Pages 393-421
Back Matter....Pages 423-434
Content:
Front Matter....Pages i-xix
An Overview of Receptors of MPS Cells....Pages 1-27
Heterogeneity of Mononuclear Phagocytes....Pages 29-85
Origin of Macrophages....Pages 87-113
Complement and the Mononuclear Phagocyte System....Pages 115-148
Macrophages and Prostaglandins....Pages 149-159
Antigen Processing....Pages 161-182
Antigens of Osteoclasts Phenotypic Definition of a Specialized Hemopoietic Cell Lineage....Pages 183-202
Electrophysiology of Osteoclasts and Macrophages....Pages 203-222
Complement Receptors....Pages 223-259
Fc? Receptors of Myeloid Cells....Pages 261-277
Matrix Receptors of Myeloid Cells....Pages 279-306
Leukocyte Integrins....Pages 307-333
Molecular Basis for Leukocyte Adhesion Molecule Deficiency....Pages 335-346
Carbohydrate-Recognition Proteins of Macrophages and Related Cells....Pages 347-370
Leukocyte Adhesion to Endothelium....Pages 371-392
Cell Recognition of Apoptotic Cells....Pages 393-421
Back Matter....Pages 423-434
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